Study of bone disorders after thyroidectomy in women
Abstract
Background: A reduction in IGF-1, thyroid hormones, as well as calcium, PTH, vitamin D, human bone-specific alkaline phosphatase (PAP), and Alkaline Phosphatase (ALP) are prominent complications that can arise after total thyroidectomy. These complications can exhibit a wide range of severity, from asymptomatic cases to acute life-threatening conditions.
Methods: The study included three patient groups (n = 30 each) at different time intervals post-thyroidectomy and one healthy control group (n = 30). Omitted from the study were patients with cancer, diabetes, hypertension, and pregnant women. The scope of the study was confined to patients who had undergone surgical removal of the thyroid gland due to benign tumors or other medical reasons.
Results: The results demonstrated significant differences among the four groups in IGF-1, thyroid hormones, calcium, PTH, vitamin D, and bone-specific alkaline phosphatase (PAP and ALP). In comparison with the control group, the patient groups exhibited progressively higher levels of these parameters, with the highest values observed in Group D, indicating gradual recovery and metabolic adaptation following thyroidectomy.
Conclusion: The findings garnered from the conducted research indicate a progressive increase in thyroid hormones and parathyroid activity following total thyroidectomy. This trend, accompanied by elevated calcium, vitamin D, and bone-specific markers (PAP and ALP), suggests metabolic recovery and compensatory adaptation of endocrine and skeletal systems rather than functional decline. These results collectively highlight the body’s capacity for hormonal equilibrium and bone remodelling during the postoperative period.
Keywords: Bone disease, IGF-1, Hypoparathyroidism, Thyroidectomy
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DOI: http://dx.doi.org/10.62940/als.v12i3.2458
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