Prevalence and Risk of Hepatitis Infection in Infants Associated with Maternal Health History: A Cross-Sectional Study in Indonesia
Abstract
ackground: Hepatitis is a significant public health concern in Indonesia, with the government prioritizing the prevention of mother-to-child transmission of hepatitis B. This study aimed to evaluate the influence of antenatal care (ANC), pregnancy and parturition conditions, hepatitis B immunizations, and healthcare accessibility on the incidence of hepatitis among infants.
Methods: A cross-sectional analysis was conducted using data from the 2018 Basic Health Survey (Riskesdas) in Indonesia, examining 10,293 infants aged 6–12 months. Multivariate logistic regression was performed on a final sample of 7,434 cases with complete data. The sampling method used in this research is multistage cluster sampling, which is a common approach for large, nationally representative surveys such as Riskesdas.
Results: Hepatitis was identified in 0.5% of infants. Significant associations were found between hepatitis incidence and maternal pregnancy disorders (aPOR = 1.92, 95% CI = 1.03–3.6) and abnormal parturition methods (aPOR = 2.19, 95% CI = 1.14–4.18). However, ANC history and hepatitis B immunization did not show significant associations.
Conclusion: Comprehensive and timely ANC to address pregnancy disorders and ensure normal parturition can significantly reduce hepatitis risk in infants. Public health interventions should focus on maternal health education and healthcare access, particularly in rural areas.
Keywords: Antenatal Care, Hepatitis Infection, Infant, Parturition, Pregnancy
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Kementerian Kesehatan RI. Hepatitis B pada ibu hamil dan anak. Jakarta, (2023); Available from: https://kemkes.go.id/app_asset/file_content_download/17169676926656d90c733743.81092792.pdf. Accessed [8 Nov 2024].
Biro Komunikasi dan Pelayanan Masyarakat (Rokom). 1,5 juta lebih ibu hamil di deteksi dini hepatitis B. Kementerian Kesehatan RI, (2019); Available from: https://sehatnegeriku.kemkes.go.id/baca/umum/20190722/1630952/15-juta-lebih-ibu-hamil-dideteksi-dini-hepatitis-b/. Accessed [18 Nov 2024].
Villa DdF, Navas MC. Vertical transmission of hepatitis B virus—An update. Microorganisms, (2023); 11(5): 1140.
Al-Busaf S, Al-Harthi R, Al-Naamani K, Al-Zuhaibi H, Priest P. Risk factors for hepatitis B virus transmission in Oman. Oman Medical Journal, (2021); 36(4): e287.
Cheung KW, Seto MTY, Lao TTH. Prevention of perinatal hepatitis B virus transmission. Archives of Gynecology and Obstetrics, (2019); 300(2): 251–259.
Indonesian Ministry of Health. The 2018 Indonesia basic health survey (RISKESDAS): National report. Jakarta, (2019); Available from: https://labmandat.litbang.kemkes.go.id/images/download/laporan/RKD/2018/Laporan_Nasional_RKD%202018_FINAL.pdf. Accessed [9 Nov 2024].
World Health Organization. Global hepatitis report 2024: Action for access in low- and middle-income countries. Geneva, (2024); Available from: https://www.who.int/publications/i/item/9789240091672. Accessed [10 Nov 2024].
Kampe A, Abbai MK, Tilahun D, Daka D, Aliyo A, Dedecha W, et al. Seroprevalence of hepatitis B virus infection and associated factors among pregnant women attending antenatal care at public hospitals in Borena Zone, Southern Ethiopia. Health Services Research and Managerial Epidemiology, (2023); 10: 1–10.
Ren Y, Guo Y, Feng L, Li T, Du Y. Controversy and strategies exploration in blocking mother-to-child transmission of hepatitis B. International Reviews of Immunology, (2016); 35(3): 249–259.
World Health Organization. Hepatitis B vaccines: WHO position paper, July 2017 – Recommendations. Vaccine, (2019); 37(2): 223–225.
Handayani L, Anisa FN, Palimbo A, Suhartati S, Raudah N, Ibrahim. Analysis of birth outcomes with incidence of hepatitis B in pregnant women. Health Sciences International Journal, (2024); 2(1): 34–44.
Kochaksaraei GS, Castillo E, Osman M, Simmonds K, Scott AN, Oshiomogho JI, et al. Clinical course of 161 untreated and tenofovir-treated chronic hepatitis B pregnant patients in a low hepatitis B virus endemic region. Journal of Viral Hepatitis, (2016); 23(1): 15–22.
Afraie M, Moradi G, Zamani K, Azami M, Moradi Y. The effect of hepatitis B virus on the risk of pregnancy outcomes: A systematic review and meta-analysis of cohort studies. Virology Journal, (2023); 20(1): 213.
Agwa RH, Elwan TH, Alghamdi HAS, Alghamdi AAS, Altaweel FIA, Alghamdi AA, et al. Awareness of Hepatitis B Virus (HBV) screening before marriage and pregnancy among adults in the Al-Baha region, Saudi Arabia. Cureus, (2024); 16(1): 1–14.
Cui F, Shen L, Li L, Wang H, Wang F, Bi S, et al. Prevention of chronic hepatitis B after 3 decades of escalating vaccination policy, China. Emerging Infectious Diseases, (2017); 23(5): 765–772.
Zhang C, Huang Y, Ji L, Zhu Q, Wang L, Wang J. Effectiveness of health management team program to enhance prevention of mother-to-child transmission of hepatitis B virus in Ningxia, China. BMC Public Health, (2024); 24(1): 67.
Luo YL, Gao S, Zhang QF, Liu X, Lv DY, Chen JH, et al. Eliminating mother-to-child transmission of hepatitis B virus: Practice and progress in Baoan, a national pilot district of China. BMC Public Health, (2024); 24(1): 58.
Adjei CA, Suglo D, Ahenkorah AY, MacDonald SE, Richter S. Barriers to timely administration of hepatitis B birth dose vaccine to neonates of mothers with hepatitis B in Ghana: Midwives’ perspectives. SAGE Open Nursing, (2023); 9: 1–10.
Molla S, Munshea A, Nibret E. Seroprevalence of hepatitis B surface antigen and anti-HCV antibody and its associated risk factors among pregnant women attending maternity ward of Felege Hiwot Referral Hospital, northwest Ethiopia: A cross-sectional study. Virology Journal, (2015); 12(1): 204.
Shedain PR, Devkota MD, Banjara MR, Ling H, Dhital S. Prevalence and risk factors of hepatitis B infection among mothers and children with hepatitis B infected mother in upper Dolpa, Nepal. BMC Infectious Diseases, (2017); 17(1): 667.
Katamba PS, Mukunya D, Kwesiga D, Nankabirwa V. Prenatal hepatitis B screening and associated factors in a high prevalence district of Lira, northern Uganda: A community-based cross-sectional study. BMC Public Health, (2019); 19(1): 1004.
Mursy SMM, Mohamed SOO. Knowledge, attitude, and practice towards hepatitis B infection among nurses and midwives in two maternity hospitals in Khartoum, Sudan. BMC Public Health, (2019); 19(1): 1597.
Chen Y, Xie C, Zhang Y, Li Y, Erhardt S, Thio CL, et al. Knowledge regarding hepatitis B mother-to-child transmission among healthcare workers in South China. Journal of Viral Hepatitis, (2018); 25(5): 561–570.
Djaogol T, Coste M, Marcellin F, Jaquet A, Chabrol F, Giles-Vernick T, et al. Prevention and care of hepatitis B in the rural region of Fatick in Senegal: A healthcare workers’ perspective using a mixed methods approach. BMC Health Services Research, (2019); 19(1): 627.
DOI: http://dx.doi.org/10.62940/als.v12i3.3667
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