Efficiency of Virgin's Mantle (Fagonia cretica L.) as an Antibacterial and Antifungal Agent

Khushnood Ur rehman, Muhammad Hamayun, Shahab Saeed Khan, Nadeem Ahmad, Sher Wali

Abstract


Background: For medicinal purposes, biological activities are carried out on plant secondary metabolites in which common but very significant antimicrobial activities are focused. To evaluate the antimicrobial potential of Fagonia cretica L., different pathogenic microbial strains were obtained from KP, hospitals (already identified) to resolve the objectives of the current study.

Methods: In the agar, well diffusion method, a total of eight strains (4 bacterial 4 fungal) Streptococcus mutans, MRSA (Methicillin resistance staphylococcus aureus), Serratia marcescens, and Staphylococcus aureus are the bacterial strains while the fungal strains are Alternaria alternate,  Aspergillus flavus, Fusarium oxysporum, and Polysphondylium pallidum pre-identified and isolated in hospitals, were used respectively to evaluate the potentiality of n-hexane, ethyl acetate, chloroform, aqueous, and crude methanolic fractions against these strains.

Keywords: Virgin’s mantle; Fagonia cretica; Antibacterial; Antifungal

Results: The highest significant (46-57% & 39-60%) antibacterial and antifungal activities were shown by the methanolic fraction while the lowest (28-35% & 25-35%) antibacterial and antifungal was shown by aqueous fraction against the selected microbial strains. Other fractions were also exhibited reasonable antimicrobial activities.

Conclusion: The current study concluded that different fractions of F. cretica have significant antimicrobial potential and might be a source of antibiotics in future studies of that plant.

Keywords: Virgin’s mantle; Fagonia cretica; Antibacterial; Antifungal 


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References


Hussain A, Zia M, Mirza B. Cytotoxic and Antitumor Potential of Fagonia cretica L. Turkish journal of biology, (2007); 31(1): 19-24.

Anjum MI, Ahmed E, Jabbar A, Malik A, Ashraf M, et al. Antimicrobial constituents from Fagonia cretica. Journal-Chemical Society of Pakistan, (2007); 29(6): 634-639.

Rashid U, Khan MR, Jan S, Bokhari J, Shah NA. Assessment of phytochemicals, antimicrobial and cytotoxic activities of extract and fractions from Fagonia olivieri (Zygophyllaceae). BMC complementary and alternative medicine, (2013); 13(1): 167.

Saeed A, Nelson G, Hussein M. Experimental infection of calves with Schistosoma mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene, (1969); 63(4): 456-458.

Dastagir G, Hussain F, Khan AA. Antibacterial activity of some selected plants of family Zygophyllaceae and Euphorbiaceae. Journal of Medicinal Plants Research, (2012); 6(40): 5360-5368.

Qureshi H, Asif S, Ahmed H, Al-Kahtani HA, Hayat K. Chemical composition and medicinal significance of Fagonia cretica: a review. Natural product research, (2016); 30(6): 625-639.

Akhtar N, Mirza B. Phytochemical analysis and comprehensive evaluation of antimicrobial and antioxidant properties of 61 medicinal plant species. Arabian journal of chemistry, (2018); 11(3): 1223-1235.

Begum HA, Hamayun M, Shad N, TabassumYaseen FA. 3. Nutritional analysis of some selected medicinal plants of Khyber Pakhtunkhwa, Pakistan. Pure and Applied Biology (PAB), (2018); 7(3): 955-964.

Ur-Rehman K, Hamayun M, Khan SA, Iqbal A, Hussain A. Heavy Metal Analysis of Locally Available Anticancer Medicinal Plants. Biosciences Biotechnology Research Asia, (2019); 16(1): 105-111.

Khushnood ur Rehman SW, Akhtar N, Ullah B, Afzal S, Ahmad I, Hamayun M. Evaluation of the antibacterial and antifungal potential of spider saxifrage plant (Saxifraga flagellaris Willd.). Pure and Applied Biology (PAB), (2019); 8(2):1163-71.

Khattak KF. Evaluation of microbial loads, physical characteristics, chemical constituents and biological properties of radiation processed Fagonia arabica. Radiation Physics and Chemistry, (2012); 81(6): 679-685.

Sterilized D. Toxic effect of various plant part extracts on the causal organism of typhoid fever. Current science, (2000); 78(7): 780

Canh K, Yetgin A, Akata I, Altuner EM. In vitro antimicrobial screening of Aquilaria agallocha roots. African Journal of Traditional, Complementary and Alternative Medicines, (2016); 13(5): 178-181.

Woo PC, Ng KH, Lau SK, Yip KT, Fung AM, Leung KW, Tam DM, Que TL, Yuen KY. Usefulness of the MicroSeq 500 16S ribosomal DNA-based bacterial identification system for identification of clinically significant bacterial isolates with ambiguous biochemical profiles. Journal of clinical microbiology, (2003); 41(5): 1996-2001.

Ahmad S, Khan Z, Mustafa AS, Khan ZU. Seminested PCR for diagnosis of candidemia: comparison with culture, antigen detection, and biochemical methods for species identification. Journal of Clinical Microbiology, (2002); 40(7): 2483-9.

Redo M, Rios J, Villar A. A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978–1988. Phytotherapy Research, (1989); 3(4): 117-125.

Bansod S, Rai M. Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigatus and A. niger. World Journal of Medical Sciences, (2008); 3(2): 81-88.

Silva N, Fernandes Júnior A. Biological properties of medicinal plants: a review of their antimicrobial activity. Journal of venomous animals and toxins including tropical diseases, (2010); 16(3): 402-413.

Ullah M, Khan MU, Mahmood A, Malik RN, Hussain M, et al. An ethnobotanical survey of indigenous medicinal plants in Wana district south Waziristan agency, Pakistan. Journal of ethnopharmacology, (2013); 150(3): 918-924.

Shinwari ZK, Ahmad N, Hussain J, Rehman NU. Antimicrobial evaluation and proximate profile of Nepeta leavigata, Nepeta kurramensis and Rhynchosia reniformis. Pakistan Journal of Botony, (2013); 45(1): 253-9.

Alqasoumi SI, Yusufoglu HS, Alam A. Anti-inflammatory and wound healing activity of Fagonia schweinfurthii alcoholic extract herbal gel on albino rats. African Journal of Pharmacy and Pharmacology, (2011); 5(17): 1996-2001.

Godbole S, Pendse G. Antibacterial property of some plants. Indian Journlal of Pharmacy, (1960); 22(2): 39.

Wadood A, Ghufran M, Jamal SB, Naeem M, Khan A, et al. Phytochemical analysis of medicinal plants occurring in local area of Mardan. Biochemistry & Analytical Biochemistry, (2013); 2(4): 1-4.

Rahim SAA, Almagboul AZ, Mohammed NEB. Antimicrobial activity of Croton zambesicus, Acacia ehrenbergiana and Fagonia cretica. National Journal of Advance Research, (2016); 2(3): 16-20.

Deshmukh SK, Verekar SA. Fungal endophytes: a potential source of antifungal compounds. Frontiers in Bioscience E4, (2012); 42045-2070.

Gehlot D, Bohra A. Antibacterial effect of some leaf extracts on Salmonella typhi. Indian journal of medical sciences, (2000); 54(3): 102-105.

Ahmad I, Mehmood Z, Mohammad F. Screening of some Indian medicinal plants for their antimicrobial properties. Journal of ethnopharmacology, (1998); 62(2): 183-193.

Saeed MA, Sabir AW. Effects of Fagonia cretica L. constituents on various haematological parameters in rabbits. Journal of ethnopharmacology, (2003); 85(2-3): 195-200.


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