2024-03-29T07:15:14Z
https://submission.als-journal.com/index.php/ALS/oai
oai:ojs.submission.als-journal.com:article/985
2020-09-03T04:55:48Z
ALS:RA
Life after COVID-19 outbreak: Expectations and thoughts
Zahra, Aiman
Hussain, Tanveer
Sherwani, Sikander Khan
Health and Epidemiological studies
The occurrence of the novel coronavirus (COVID-19) pandemic presents an unparalleled health enlightenment challenge. It’s extremely contagious and erratically lethal, and the pervasiveness of asymptomatic prevalence makes it difficult to contain. All infectious disease epidemics rear ethical concerns, from the restraint of individual independence to triaging and resource provision. It seems that we did not take lessons from the preceding epidemics and were poorly prepared to pledge with the threat that COVID-19 epidemic has put forward. The COVID-19 epidemic highlighted the significance of this query to both pandemic preparation strategies and healthcare policies. As the outbreak turned out to be a global pandemic, there is an improved emphasis on finding answers for vaccine preparation, focusing on neglected diseases, more virome study, and research collaboration across the globe in the future, being key tools to resist infection spread in future. Decelerating the COVID-19 spread necessitates people to enthusiastically transform their lives and monitor the finest practices for social isolation and sanitation. This review provides an overview of future research perceptions and offers suggestions on how we can help people to believe in normal life and how this pandemic will strengthen the trade, affect the individual habits and values, revolution in primary health care after these uncertain situations.Keywords: COVID-19; Pandemic; Neglected diseases; Primary health; Virome
The RunningLine
Virtual University of Pakistan
2020-09-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/985
Advancements in Life Sciences; Vol 7, No 4 (2020): Advancements in Life Sciences; 208-214
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/985/419
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1513
2023-04-14T10:29:04Z
ALS:RA
Herbal therapy for hemorrhoids: An Overview of Medicinal Plants Affecting Hemorrhoids
Mohammadian Amiri, Mehdi
Garnida, Yudi
F. Almulla, Abbas
Sami Abduljabbar, Ahmed
Turki Jalil, Abduladheem
Mazaheri, Yeganeh
Ebrahimi, Yahya
Shariatifar, Nabi
medicinal plants, hemorrhoids, treatment of diseases
Hemorrhoids are one of the most common rectal diseases that affect millions of people in the world and cause many medical and socio-economic problems. The resulting pain is very severe and incurs exorbitant costs for the patient and the government. This study aimed to review the medicinal plants that affect hemorrhoids. Complete databases searched for in those articles were Google Scholar, SID, Scopus, PubMed, Science Direct, and WOS search engines. The search was done for articles published that included the search term containing, medicinal plants and hemorrhoids in their title. This study focused on published articles and papers from 1991 to 2022.The results showed medicinal plants Aloe vera, Trigonella foenum-graecum L, Nigella sativa L, Curcuma longa L, Cocos nucifera L, Solanum nigrum L., Alhagi persarum Boiss & Buhse, Plantago lanceolata L, Achillea santolina, Malva neglecta Wallr, Rubus fruticosus L have effects like anti-bleeding, analgesic, anti-inflammatory, and wound-healing, and with hemorrhoid-healing effect. Generally, the investigated traditional Iranian edible plants are rich in different types of chemical compounds and have special benefits in the prevention and treatment of diseases.Keywords: Medicinal plants; Hemorrhoids; Diseases; Remedy Drugs
The RunningLine
medicinal plants, hemorrhoids, treatment of diseases
2023-04-14
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1513
Advancements in Life Sciences; Vol 10, No 1 (2023): Advancements in Life Sciences; 22-28
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1513/908
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/295
2018-11-25T08:03:45Z
ALS:RA
Awareness of Asthma Genetics in Pakistan: A Review with Some Recommendations
Sabar, Muhammad Farooq
Akram, Muhammad
Awan, Farheena Iqbal
Ghani, Muhammad Usman
Shahid, Mariam
Iqbal, Zafar
Kousar, Samra
Idrees, Muhammad
Molecular Biology, Genetics, Health
About 334 million people worldwide have been affected by asthma and additionally 100 million expected to have asthma by the year 2025. Being the sixth most populous and economically developing country and with the increasing trend of urbanization and due to poor health facilities, lacking the knowledge of the causes of the disease, increased pollutant exposures and consanguineous marriages, Pakistani population has greater chances of asthma and allergic diseases. Almost 20% of overall pediatric population of Pakistan is affected by this disease. In the past, only environmental factors were considered responsible for asthma but now it is a well-known fact that genetic factors have major contribution in the development of the disease. Poor knowledge of the possibility of genetics involved in this disease has been very common in both uneducated as well as educated population of this region. There is no doubt today that genetics have a major role in the exhibition of asthma but unlike other Mendelian disorders it cannot easily be identified by a single or a simple set of associated genes, rather small contributions of multiple genes and environmental exposure to asthmatic patients may be found. Our focus in this article is genetic factors of asthma in Pakistan. More than 100 genes associated with asthma have already been reported in different populations worldwide but generally, due to an ignored disease in this region, possible genetic causes, impacts, management and treatment of the disease has rarely been studied in Pakistan. This article was intended to explore some latest developments in asthma genetics, diagnosis, prognosis and management and suggest some recommendations to control this deadly disease.
The RunningLine
None
2018-11-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/295
Advancements in Life Sciences; Vol 6, No 1 (2018): Advancements in Life Sciences; 1-10
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/295/254
Copyright (c) 2018 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1268
2022-11-05T03:24:51Z
ALS:RA
Role of Antiviral Drugs in Management of Mild and Moderate Coronavirus Disease-19: A Systematic Review
Pantasri, Tanapong
Ali, Muhammad Mohsin
Ghouri, Muhammad Hashim
Alharbi, Ahmad M.
Alfahemi, Hasan
Medicine; Health and Epidemiological studies; Molecular Biology; Microbiology; Coronavirus Disease-19; SARS-CoV-2
This study was conducted to determine the objective role of antiviral drugs such as arbidol, lopinavir/ritonavir, and others in improving clinical symptoms, decreasing duration of hospitalization, and decreasing duration of viral shedding in patients with mild and moderate COVID-19 infection. A systematic literature search was carried out on Google Scholar and PubMed databases, using the keywords “COVID-19”, “Antiviral”, “Treatment”, and “Symptomatic” in various combinations. Observational studies, cohort and case control studies, and clinical trials published in English with full-text available were included in the study. Data extraction was carried out from selected studies, and all statistical analysis for the study was carried out using Microsoft Excel. The key outcomes studied were time to negative PCR, duration of clinical stay, time to clinical improvement, and occurrence of adverse events. Seven studies were selected for final review after rigorous selection process. Data of total 4734 participants was analyzed, the majority of which were females (n=2810, 59.3%). The majority of participants had mild disease (n=4197, 88.65%). Average time for negative RT-PCR in the included treatment groups was 13.5 days, whereas the average duration of hospitalization was 14.9 days for the treatment groups. Adverse reactions such as ECG changes, gastrointestinal symptoms, secondary bacterial infections, and hepatic and renal dysfunction were scarcely reported in the included studies. There is no clear benefit in terms of duration of hospitalization and time to negative PCR with the use of various antiviral regimens in mild disease; however, these drugs did play a role in limiting disease progression in the participant population. Pending further evidence, the use of these drugs for the management of COVID-19 is not recommend in patients with mild disease.
The RunningLine
2022-11-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1268
Advancements in Life Sciences; Vol 9, No 3 (2022): Advancements in Life Sciences; 270-276
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1268/772
https://submission.als-journal.com/index.php/ALS/article/downloadSuppFile/1268/335
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/232
2016-08-25T01:00:24Z
ALS:RA
Thyroid hormone dependent gene expression
Jahangir, Ghulam Zahara
Saleem, Faiza
Naz, Shagufta
Munir, Neelma
Haq, Rukhama
Sumrin, Aleena
The presented work is destined to review the advances that had been made to study the role of thyroid hormone and thyroid hormone nuclear receptors in regulating the gene expression. Triiodothyronine (T3) and tetraiodothyronine (thyroxine or T4) are most important thyroid hormones. The thyroid hormones bind to their specific nuclear hormone receptors, as ligand, and play important role in gene expression and transcriptional gene regulation in human and higher animals. Thyroid hormone receptors form heterodimers by making combination with retinoid X receptors. The capability of heterodimerization of thyroid hormones generates novel complexes which allow altered specificity and higher affinity for DNA-receptor binding. Thyroid hormone receptors work as ligand activated transcription factor and play with transcriptional gene expression process. The consensus structural features of thyroid hormone receptors are N-terminal regulatory domain that contains activation function, the domain for strong gene expression and the domain for binding to DNA. The structures for individual domains have been extensively and reviewed through several latest and successful techniques.
The RunningLine
2016-08-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/232
Advancements in Life Sciences; Vol 3, No 4 (2016): Advancements in Life Sciences; 119-124
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/232/129
Copyright (c) 2016 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1193
2022-07-05T10:42:16Z
ALS:RA
CRISPR/Cas9 application in tomato breeding improvement: a review
Bui, Anh Phu Nam
Molecular Biology, Biotechnology
Tomato (Solanum lycopersicum) is an essential plant because of its social and economic importance. Therefore, research have been focusing on improving tomato production. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (CRISPR/Cas9) system provides unique opportunities to better understand the gene functions and to rapidly generate new tomato cultivars harboring desired traits such as disease resistance, better harvest quality and abiotic tolerance. This review aims to provide latest information about the application of CRISPR/Cas9 system on tomato breeding.Keywords: CRISPR; Tomato breeding; Applied research
The RunningLine
2021-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1193
Advancements in Life Sciences; Vol 8, No 4 (2021): Advancements in Life Sciences; 315-319
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1193/663
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1835
2024-03-06T16:36:17Z
ALS:RA
Non-Surgical Treatment Methodologies and Prevention for Malignant Melanoma
Yu, Honggang
Ali, Rizwan
Lei, Rui
Xu, Jinghong
Health and Epidemiological studies
Melanocytes in the skin and other organs generate the tumor known as malignant melanoma (MM). It has a high degree of malignancy, a deprived prognosis, and a propensity for local recurrence and distant metastasis. Although there have been tremendous advancements in MM management choices over the past ten years, there are still a dearth of clinically viable therapy alternatives and no internationally accepted treatment standard. The prognosis of MM patients has recently improved thanks to the development of immunotherapy and targeted therapy. As a result, this article examines the most recent findings from studies on the non-surgical treatment methodologies for MM and its preventive measures.Keywords: Malignant melanoma; Treatment therapies; Combined therapies; Prevention
The RunningLine
Department of Plastic Surgery, First Affiliated Hospital of Zhejiang University, School of Medicine
2024-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1835
Advancements in Life Sciences; Vol 11, No 1 (2024): Advancements in Life Sciences; 07-17
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1835/1408
Copyright (c) 2024 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/58
2014-06-05T02:51:18Z
ALS:RA
Nanotechnology: A new frontier in Agriculture
Ali, Muhammad Azam
Rehman, Iqra
Iqbal, Adnan
Din, Salah ud
Rao, Abdul Qayyum
Latif, Ayesha
Samiullah, Tahir Rehman
Azam, Saira
Husnain, Tayyab
Biotechnology; Agriculture; Bionanotechnology
Nanotechnology is science of manipulating materials at nano-scale. Among the latest technological advancements, nanotechnology occupies a central position. It has many applications in all stages of production, processing, storing, packaging and transport of agricultural products. The reduced use of herbicides, pesticides and fertilizers with increased efficiency, controlled release and targeted delivery will lead to precision farming. Dream of automated, centrally controlled agriculture can become reality now. Modern agriculture is need of hour because conventional agricultural will not be able to feed an ever increasing population with changing climate, depleting resources and shrinking landscape. But at the same time application of nano-materials in agri-food sector has to be evaluated for public acceptance so it does not come across a scenario as faced by GMOs in past. This article provides an overview of current and potential applications of nanotechnology in agriculture and food sector.
The RunningLine
2014-05-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://submission.als-journal.com/index.php/ALS/article/view/58
Advancements in Life Sciences; Vol 1, No 3 (2014): Advancements in Life Sciences; 129-138
2310-5380
en
oai:ojs.submission.als-journal.com:article/999
2020-11-27T03:56:41Z
ALS:RA
Viral outbreaks: A real threat to the world
Asif, Muhammad
Nawaz, Shah
Bhutta, Zeeshan Ahmad
Kulyar, Muhammad Fakhar-e-Alam
Rashid, Muhammad
Shabir, Shafqat
Khan, Muhammad Kashif
Qadir, Muaaz
corona viruses; COVID-19; Marburg virus; Ebola virus; Rabies; HIV; Smallpox; Hantavirus; Influenza; Dengue; Rotavirus
Global public health is facing significant challenges in terms of emerging and re-emerging pathogens. The world is facing a new public health crisis emergence and spread of Coronaviruses outbreaks especially COVID-19 after nine deadliest viral outbreaks including Marburg virus, Ebola virus, Rabies, HIV, Smallpox, Hantavirus, Influenza, Dengue and Rotavirus. Coronaviruses (enveloped non-segmented positive-sense RNA viruses) belong to the Coronaviridae family, broadly distributed in humans as well as in other mammals. In December 2019, the COVID-19 outbreak was reported in the Wuhan, Hubei province of China. WHO confirmed that COVID-19 is associated with Huanan seafood (Wuhan). COVID-19 virus outbreak is more dangerous than its ancestors MERS-CoV and SARS-CoV. Although the case fatality rate is lower, it has alarmed the world because of its rapid spread during this era of the modern world where the whole world is connected through different channels of trade. As the world is already facing economic challenges, underdeveloped countries are not capable of facing such challenges, and this outbreak may become worse than ever before.Keywords: Coronaviruses; COVID-19; Marburg virus; Ebola virus; Rabies; HIV; Smallpox; Hantavirus; Influenza; Dengue; Rotavirus
The RunningLine
2020-11-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/999
Advancements in Life Sciences; Vol 8, No 1 (2020): Advancements in Life Sciences; 08-19
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/999/462
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1937
2023-11-02T15:34:59Z
ALS:RA
Influence of the Properties and Concentration of Pollutants in Wastewater on the Choice of Methods and Technologies of Industrial Water Treatment: A Systematic Review
Neverov, Evgeniy
Gorelkina, Alena
Korotkiy, Igor
Skhaplok, Roman
This paper focuses on industrial water treatment, namely modern methods and technologies of pollution removal. The paper discusses the main problems associated with industrial wastewater pollution and describes the most effective purification methods and technologies used in modern industrial processes. Information is provided that allows for a comprehensive and accurate study of modern methods and technologies of industrial water treatment, including a detailed analysis and assessment of the advantages and disadvantages of each of these methods. Authors conducted a literature review for collecting relevant biochemical and molecular approaches to industrial wastewater treatment. Relevant reviews and research papers were selected for detailed analysis. The authors have described each method and provided examples of its application and effectiveness in removing certain types of contaminants. The results of the study indicate that there are many methods and technologies for water purification, but not every method is suitable for all pollution types. The paper contains new data and practical recommendations that can be used by specialists in the field of water treatment to reduce the negative impact on the environment.
The RunningLine
2023-09-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1937
Advancements in Life Sciences; Vol 10, No 3 (2023): Advancements in Life Sciences; 341-349
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1937/1120
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/930
2020-02-26T15:09:38Z
ALS:RA
The genetics associated with Primary Congenital Glaucoma
Imran, Ali
Khan, Muhammad Umer
Nasir, Umer
Qayyum, Qasim
Hector, Rubab
Rehman, Raima
Baig, Atif Amin
Glaucoma is a progressive optic neuropathy; increased intraocular pressure (IOP) is a modifiable risk factor for primary congenital glaucoma (PCG). Increase IOP causes retinal and optic nerve compression and leads to gradual and irreversible loss of eyesight if left untreated. It is the second most leading cause of blindness. PCG mainly affects children up to the age of three years, and symptoms include epiphora, photalgia, swollen eyes, opaque corneas, blepharospasm, rupture in the retina and ocular nerve damage due to IOP. Early detection, management, and treatment are the keys to preventing vision loss from glaucoma. Many mutations have been discovered in Cytochrome P450 1B1 (CYP1B1) gene to be responsible for causing PCG, and there are still a lot of mutations to be discovered. In this review, we will discuss the genetic aspects of PCG and the most frequent mutations responsible for PCG in Pakistani children. PCG can be handled by decreasing IOP either by medication or by surgery. Genetic counselling plays a significant role in the establishment of proper management of PCG.Keywords: Primary Congenital Glaucoma; IOP; Cyp1b1; Mutations
The RunningLine
2020-02-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/930
Advancements in Life Sciences; Vol 7, No 2 (2020): Advancements in Life Sciences; 106-112
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/930/346
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1510
2023-01-21T22:12:11Z
ALS:RA
Personalized Medicine; a Potential Therapy for Cystic Fibrosis
Ashraf, Aqsa
Ghani, Muhammad Usman
Khan, Muhammad Umer
Rehman, Hafiz Muzzammel
Hassan, Mahmood ul
Mehdi, Zohair
Cystic Fibrosis (CF) is an inherited disorder caused by mutations in CFTR gene that codes for Cystic Fibrosis Transmembrane-conductance Receptor anion channel. It is an autosomal recessive disease which affects the cells that secrete sweat, mucous and digestive juice, making these fluids thick and sticky, thus plugging ducts and tubes of various organs. The CF mutations are classified into various classes (class I, II, III, IV, V and VI) based on the cellular phenotype and complexity of mutants. The knowledge and understanding of biology and mechanisms of defects that underlie Cystic fibrosis paved a way to the development of different therapeutic approaches for these mutation classes. Ivacaftor first CFTR potentiator (FDA approved in 2012) is mostly used for Class III and IV mutations. Trials in patients with homozygous F508del mutation, a most common type of CF mutation that involves protein processing defects, showed no improvement with Ivacaftor alone, therefore, a double-combination therapy involving potentiator-corrector i.e., Ivacaftor-Lumacaftor got approval in 2015 to treat patients homozygous for F508del mutation. Then Ivacaftor-Tezacaftor (corrector) combination therapy was approved in 2018 which showed improved tolerability as compared to lumacaftor. In 2019, Trikfta, a triple combination therapy, came into light. It increases CFTR activity and is substantially considered to work more effectively in patients homozygous for F508del mutation. Studies and clinical trials reveal the outperformance of Trikafta in other available therapies in terms of respiratory symptoms, lungs functionality and quality of life on a whole.Keywords: Cystic Fibrosis (CF); Cystic Fibrosis Transmembrane Conductance regulator (CFTR); Ivacaftor; Lumacaftor; Tezacaftor; Trikafta
The RunningLine
2023-01-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1510
Advancements in Life Sciences; Vol 9, No 4 (2022): Advancements in Life Sciences; 437-445
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1510/840
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/451
2018-02-25T09:01:19Z
ALS:RA
Production of Remedial Proteins through Genetically Modified Bacteria
Tariq, Fatima
Khan, Muhammad Azmat Ullah
Shahzad, Saqib
Chaudhary, Wajeeha Batool
Arif, Amina
Gharib, Ghazleh
Molecular Biology; Microbiology; Biotechnology
Recombinant DNA technology has created biological organisms with advanced genetic sequences and has been extensively used to express multiple genes for therapeutic purposes when expressed in a suitable host. Microbial systems such as prokaryotic bacteria has been successfully utilized as a heterologous systems showing high therapeutic potency for various human diseases. Bioengineered bacteria have been successfully utilized for producing therapeutic proteins, treating infectious diseases, and disease arise due to increasing resistance to antibiotics. Prominently E. colifound to be the most widely used expression system for recombinant therapeutic protein production i.e. hormones, enzymes and antibodies. Besides E. coli, non-pathogenic lactic acid bacteria has also been considered as an excellent candidate for live mucosal vaccine. Likewise, S. typhimuriumhas been deployed as attenuated type of vaccination as well as in treatment strategy of various cancers due to its ability of wide progression in tumors. The present article is a summarized view of the main achievements and current developments in the field of recombinant therapeutics using bacterial strains focusing on their usability in therapeutics and future potential.
The RunningLine
2018-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/451
Advancements in Life Sciences; Vol 5, No 2 (2018): Advancements in Life Sciences; 37-45
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/451/204
Copyright (c) 2018 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1352
2022-08-27T03:36:01Z
ALS:RA
Enhancing Health Benefits of Tomato by Increasing its Antioxidant Contents through Different Techniques: A Review
Haraira, Ammad abu
Mazhar, Hafiz Sabah-ud-din
Ahmad, Afrasyab
Khalid, Muhammad Nouman
Tariq, Muhammad
Nazir, Shahid
Habib, Imran
Health and Epidemiological studies; Biotechnology; Biochemistry
Tomato is known to be a great dietary source of antioxidant lycopene which is found to be linked with reduced risk of life-threatening diseases like heart attack and cancers. Antioxidants delay the aging process by mopping up reactive free radicals from cells, those if present may damage our DNA and other vital cellular organelles. Antioxidant metabolites are a group of vitamins, carotenoids, phenolic compounds, and phenolic acids that can provide effective protection against Reactive Oxygen Species (ROS) by neutralizing free radicals, which are unstable molecules linked to the development of many degenerative diseases and medical conditions. There are pre and postharvest techniques available in the literature and these when adopted by the researchers showed significant progress in enhancing antioxidant contents of tomato fruit. In addition, there are various biochemical and genetic modification approaches to improve the expression of several antioxidant enhancing phytonutrients, enzymes and genes in tomato fruit. Trichoderma enriched bio-fertilizer application in tomato enhanced ascorbic acid under the treatment of 100% bio-fertilizer and beta-carotene was increased under 75% Bio-Fertilizer+25% N whereas elevated lycopene contents were observed in case of recommended dose of NPK. Various omics approaches like genomics, transcriptomics, miRNAomics, proteomics, and metabolomics have emerged as extremely helpful tools for the plant scientists in improving the beta-carotene, lycopene and antioxidant levels resulting in highly desirable new tomato cultivars. Thus, in light of immense advantages of these techniques, the present study was undertaken to collect all the necessary information about different techniques employed by numerous researchers to increase the antioxidant contents in tomato and to document here the optimized experimental conditions that can be beneficial for future studies in this field. However, still in-depth genome wide studies are needed for better understanding and further enhancement of traits like flavor, quality and antioxidant contents in context to rapidly changing and uncertain climate.Keywords: Antioxidants; tomato; lycopene; β-carotene; reactive oxygen species (ROS)
The RunningLine
2022-08-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1352
Advancements in Life Sciences; Vol 9, No 2 (2022): Advancements in Life Sciences; 131-142
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1352/706
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/122
2015-05-25T01:34:01Z
ALS:RA
Potent Implications of miRNA in Cancer Biology – A Brief Review
Javed, Zeeshan
Iqbal, Muhammad Zaheer
Latif, Muhammad Umair
Yaqub, Hafiz Muhammad Farooq
Qadri, Qamar Raza
Molecular Biology; Cancer Research; Health
Groundbreaking findings through high-throughput technologies have deepened our understanding on an intricate interplay between products of coding sequences and noncoding RNAs. Increasingly it is being realized that miRNA, produced from what was previously considered as "genomic trash" have revolutionized the field of molecular and translational oncology. Overwhelmingly accumulating in-vitro and in-vivo studies have demonstrated that miRNA are key players involved in post-transcriptional regulation of gene network in numerous human pathologies including cancer. In this review we have attempted to provide recent advancements related to multifaceted roles played by miRNA in modulation of oncogenes and tumor suppressor genes.
The RunningLine
2015-05-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/122
Advancements in Life Sciences; Vol 2, No 3 (2015): Advancements in Life Sciences; 106-109
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/122/71
oai:ojs.submission.als-journal.com:article/1122
2021-08-04T10:20:57Z
ALS:RA
Clinical Guidelines for Management of Acute Painful Episodes of Vaso-Occlusive Crisis in Children with Sickle Cell Disease
Alanazi, Nawaf
Sickle cell disease; clinical guidelines, vaso-occlusive crisis; pain management; Saudi Arabia
Sickle cell disease (SCD) is an inherited disease resulted due to a single mutation in beta globin gene. It changes normal red blood cells into sickle-shaped cells, just rendering their ability to carry oxygen to tissues and cells. SCD involves many fatal clinical complications including very painful vaso-occlusive crisis (VOC), the later caused by sickled erythrocytes-mediated ischemic tissue injury and obstruction of blood flow that leads. Pain in VOC is caused by hypoxia, acidosis, fever, infections, dehydration, obstructive sleep apnea, abrupt changes in weather (hot / cold), menstruation and pregnancy etc. Pain in VOC is very severe and is associated with many other life-threatening clinical complications. Therefore, it is needed be managed as early as possible, otherwise persistent pain can weaken patients physically and psychologically. There are no specific laboratory indicators for VOC and diagnosis is made on the basis of history and physical examination. We formulated clinical guidelines for the management of acute painful crisis (VOC) in sickle cell patients based upon updated published medical literature, in addition to our experience of treating sickle cell patients King Abdulaziz National Guards Hospital, Al-Ahsa, Saudi Arabia, which is its application to an Asian publication. This report describes details of these clinical guidelines for management of acute painful vaso-occlusive crisis in sickle cell patients.Keywords: Sickle cell disease; Vaso-Occlusive Crisis; Acute pain management; Pediatric
The RunningLine
NA
2021-08-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1122
Advancements in Life Sciences; Vol 8, No 3 (2021): Advancements in Life Sciences; 221-227
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1122/552
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1892
2024-03-06T16:36:17Z
ALS:RA
Research Progress of Applied Anatomy of Labia Minora in Plastic Surgery
Ali, Rizwan
Xu, Jinghong
Lei, Rui
Cosmetic labiaplasty is focusing on the deliberate alteration of external genitalia without medical reasons. It highlights the growing understanding of diverse genital anatomy, suggesting that the labia minora innervation contributes to sexual arousal and pleasure. The measurement of female vulva structure is crucial for aesthetic standards and surgical planning. Past research gathered labia minora measurements from various countries, races, and age groups. As women’s expectations for vulva appearance increase, the demand for labia minora plastic surgery rises, emphasizing the importance of safety and effectiveness. To enhance surgical planning, this article addresses the histology, anatomy, data measurement, aesthetics, blood supply, and nerve innervation of the labia minora, considering both its morphological beauty and functional requirements.Keywords: Labia minora; Anatomy; Measurement; Blood and nerve supply; Plastic surgery
The RunningLine
2024-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1892
Advancements in Life Sciences; Vol 11, No 1 (2024): Advancements in Life Sciences; 01-06
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1892/1407
Copyright (c) 2024 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/988
2020-09-03T04:55:48Z
ALS:RA
Dog Coat Colour Genetics: A Review
Saif, Rashid
Iftekhar, Ali
Asif, Fatima
Alghanem, Mohammad Suliman
Molecular Genetics and Genomics
Canis lupus familiaris is one of the most beloved pet species with hundreds of world-wide recognized breeds, which can be differentiated from each other by specific morphological, behavioral and adoptive traits. Morphological characteristics of dog breeds get more attention which can be defined mostly by coat color and its texture, and considered to be incredibly lucrative traits in this valued species. Although the genetic foundation of coat color has been well stated in the literature, but still very little is known about the growth pattern, hair length and curly coat trait genes. Skin pigmentation is determined by eumelanin and pheomelanin switching phenomenon which is under the control of Melanocortin 1 Receptor and Agouti Signaling Protein genes. Genetic variations in the genes involved in pigmentation pathway provide basic understanding of melanocortin physiology and evolutionary adaptation of this trait. So in this review, we highlighted, gathered and comprehend the genetic mutations, associated and likely to be associated variants in the genes involved in the coat color and texture trait along with their phenotypes. Moreover, genetic diversity of other associated genes were also pointed out to understand this phenomena in detail along with their genotypes for better understanding the expression and mode of inheritance of this trait for describing dog breeds with more accuracy.Keywords: Dog breeds; Dog color variants; Dog texture genetics; Dog breed differentiation
The RunningLine
2020-09-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/988
Advancements in Life Sciences; Vol 7, No 4 (2020): Advancements in Life Sciences; 215-224
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/988/421
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1569
2023-07-15T04:31:43Z
ALS:RA
Variations in genomic epidemiology and in-silico screening of potential phytochemicals to cure Monkeypox
Adil, Muhammad
Waseem, Muhammad
Haider, Abdul Qadeer
Hussain, Nageen
Molecular Biology
Monkeypox virus (MPXV) is passed on when people encounter infectious animals. Before April 2022, the Monkeypox virus was reported only in South Africa and its surrounding region but now it has been spread all over the world. This Monkeypox virus consumes an incubation period of five to twenty-one days and can be communicated through direct contact, breathing, contaminated towels, bedding, and so on. The Orthopoxvirus variety is a subfamily of the Poxviridae family that incorporates the Monkeypox infection. Their unique property is to suppress the host defense system and to exploit host immunity. Treatment of Monkeypox involves two vaccines named JYNNEOSTM and ACAM2000. Antiviral medications can be considered for serious diseases, immunocompromised patients, pediatrics, pregnant and lactating ladies, complex sores, and when injuries happen close to the mouth, eyes, and privates. This review article gives a basic information ofA48R, a thymidine kinase, which is involved in DNA replication pathways in the Monkeypox virus. The potential drugs for A48R inhibition like NMCT and rutaecarpine are considered good synthetic drugs. The maximum affinity -18 was shown by phytochemical dictamnine, amentoflavone -7.5, citral -7.8, and naringin – 6.6 which can be isolated from different plants. The purpose of this review article is to describe variations in genomic epidemiology and in-silico screening of potential phytochemicals to cure Monkeypox.Keywords: Monkeypox virus; Orthopoxvirus; Poxviridae; A48R; Phytochemicals
The RunningLine
2023-07-15
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1569
Advancements in Life Sciences; Vol 10, No 2 (2023): Advancements in Life Sciences; 161-166
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1569/993
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/579
2019-04-16T11:18:38Z
ALS:RA
Forensic Entomology: A Comprehensive Review
Mona, Sundus
Khalid, Maryam
Jawad, Muhammad
Noreen, Saadia
Rakha, Allah
Forensic entomology; postmortem interval; arthropods; cadavers; DNA typing
Determination of post mortem interval is done with various methods depending upon the condition of the dead body and the circumstances in which it is found. Ruling out foul play in unnatural deaths has been an enigma of a sort for forensic pathologists and scientists all over the world. The methods to determine the cause and manner of death keep on emerging with ongoing researches in the fields of forensic sciences. Many methods have been devised to determine cause, manner and specifically time since death. Forensic entomology is one such field that aids in determination of time since death, especially in putrefied corpses found in different habitats in mysterious unknown circumstances. The field keeps on emerging with the advent of new techniques on molecular level, including DNA analysis and identification based on entomological data that has diversified over the years. The standards and guidelines for entomological data collection and processing needed for implication on the crime scene must be revised now and again for assistance of crime scene investigators, scientists, entomologists and pathologists. Various factors must be considered while processing entomological data that affect post mortem intervals. The keen study of life cycles, groups of similar insects, valid and standard methods of insect collection, breeding and identification can give a lead on cause, manner, time, place and circumstances of unknown or unnatural deaths.
The RunningLine
2019-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/579
Advancements in Life Sciences; Vol 6, No 2 (2019): Advancements in Life Sciences; 48-59
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/579/266
Copyright (c) 2019 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1496
2022-11-05T03:24:51Z
ALS:RA
The Role of Zonulin as a Prognostic Biomarker in Liver Diseases: A Systematic Review
Ghanadi, Kourosh
Naghdi, Nasrollah
Zonulin, Liver Diseases, Fatty Liver, Hepatitis, Cirrhosis.
Liver diseases have become a serious concern in the health care systems worldwide. There is an association between gut permeability and several liver diseases. Zonulin is recognized as a marker of intestinal permeability. Hence, this study summarizes the current knowledge about the role of zonulin as a prognostic biomarker in liver diseases. The present systematic review was performed according to the guidelines of the 2015 Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. Until May 2022, PubMed/Medline, Science Direct, Scopus, and Google Scholar as well as Google databases were searched using the relevant keywords including “Zonulin” and “Liver Diseases”, “Fatty Liver”, “Hepatitis”, “Cirrhosis”, “Carcinoma”, “Liver Steatosis”. Of 279 identified records through database searching, 37 articles were included in this systematic review. The evidence of this review revealed that the level of zonulin as the major biomarker of intestinal permeability increased in various types of liver diseases. Overall, we found that increased level of zonulin is associated with inflammatory responses in liver tissue and development of liver diseases. However, further studies could indicate the diagnostic and therapeutic role of zonulin in liver diseases including non-alcoholic fatty liver disease (NAFLD), Hepatitis, cirrhosis and hepatocellular carcinoma (HCC).
The RunningLine
Zonulin, Liver Diseases, Fatty Liver, Hepatitis, Cirrhosis.
2022-11-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1496
Advancements in Life Sciences; Vol 9, No 3 (2022): Advancements in Life Sciences; 277-283
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1496/773
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/323
2016-11-25T00:02:34Z
ALS:RA
Role of MicroRNA in Endometrial Carcinoma
Javed, Zeeshan
Ullah, Mukhtar
Ashfaq, Hafiz Ahsan
Shah, Afzaal Hussain
Shahzad, Muhammad
Bilal, Muhammad
Sumrin, Aleena
Bashir, Hamid
Siddiqi, Muhammad Hassan
Sadia, Haleema
Molecular Biology; Genomic; Cancer
Endometrial carcinoma (EC) is a hall mark of gynecological malignancies that usually affects women above the age 50. It is one of the major causes of mortality in females with ever increasing prevalence and the mortality rate is 1.7 to 2.4 per 100000 and each year 10000 death occur due to ECs. MiRNAs regulate the expression of different proto-oncogenes and signaling pathways that are directly or indirectly involved in the development of cancer. Different miRNAs i.e. (miRNA-449, miRNA 370, miRNA-424, and miRNA-152) which gets up or down regulated during endometrial cancer are the potential biomarkers for early diagnosis of EC. Targeting this relationship between the miRNA and signaling pathways may help in the development of new treatment in endometrial cancer. In current study, we reviewed literature from PubMed using miRNA and endometrial cancer as keywords and outlined the synthesis of potent miRNA and role of different miRNAs involved in ECs. The study revealed different sub types of miRNA played crucial role in the development of cancer by up and down regulation of different metabolic pathways. Many evidences have supported that miRNAs play role in control and regulation of different pathways leading to cancer and targeting these pathways may bring changes in the diagnosis as well as in treatment of EC.
The RunningLine
2016-11-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/323
Advancements in Life Sciences; Vol 4, No 1 (2016): Advancements in Life Sciences; 08-13
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/323/139
Copyright (c) 2016 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1205
2022-07-05T10:43:00Z
ALS:RA
Role of commercially available SARS-CoV-2 detection kits in pandemic of COVID-19 on the basis of N and E gene detection
Khalid, Mubeen
Shear, Rani Wafa
Rehman, Wadiyat
Rehman, Rahat Abdul
Ali, Babar
Nazir, Shahid
Usman Basharat, Muhammad
Khan, Muhammad Farhan
Molecular Biology; Biotechnology; Health and Epidemiological studies
Coronavirus has blowout worldwide from the time when its revelation in Hubei Province, China in December 2019 introducing a genuine general wellbeing emergency. The capacity to recognize an irresistible specialist in a broad pestilence is vital to the achievement of isolate endeavors notwithstanding the delicate and precise screening of expected instances of disease from patients in a clinical setting. Structural proteins the basic key role-playing in SARS-CoV2 identification include a spike, envelope membrane, nucleocapsid, and helper proteins. N-protein ties to the infection single positive-strand RNA that permits the infection to assume control over human cells and transform them into infection industrial facilities inside the capsid and E-protein shows a significant part in infection gathering, film permeability of the host cell, and infection has cell correspondence. Nucleic-Acid base testing presently offers the most touchy and early discovery of COVID-19. Notwithstanding, analytic advancements have explicit impediments and announced a few false negative and false positive cases, particularly during the beginning phases of contamination. Presently, more refined diagnostics are being created to improve the COVID-19 determination. This article presents an outline of diagnostic approaches to address a few inquiries and issues identified with the constraints of flow innovations and future innovative work difficulties to empower ideal, fast, minimal effort, and precise analysis of arising irresistible illnesses We depict purpose of-care diagnostics that are not too far off and urge scholastics to propel their advancements past origination. Creating fitting and-play diagnostics to deal with the SARS-CoV-2 flare-up would be valuable in forestalling forthcoming pandemics.Keywords: Role of commercially available kits; SARS-CoV2; Pandemic of Covid-19; N gene; E gene
The RunningLine
Alkhidmat Health Foundation Pakistan
2021-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1205
Advancements in Life Sciences; Vol 8, No 4 (2021): Advancements in Life Sciences; 320-325
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1205/664
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/2809
2024-03-06T16:36:17Z
ALS:RA
Genetic Studies and Breed Diversity of Kazakh Native Horses: A Comprehensive Review
Kabylbekova, D.
Assanbayev, T.S.
Kassymbekova, Shinara
Kantanen, J.
Genomics; Veterinary sciences
This comprehensive review analyzes the state of horse breeding in Kazakhstan, examining its historical context, current status, genetic studies, and future prospects. Drawing on historical records, government reports, academic studies, and genetic research, this review provides insights into the genetic diversity of Kazakh native horse breeds. The review traces the historical trajectory of horse breeding, explores its significance for the economy and culture, and discusses current population trends. Genetic studies reveal untapped potential for breed improvement. Kazakhstan's horse breeding faces opportunities for growth and development, requiring efforts to increase the horse population and harness genetic potential for productivity. This review emphasizes the need to preserve the gene pool of Kazakh native horses, ensuring sustainability and cultural significance.Keywords: Kazakh native horses; Equus caballus; Dzhabe horse; Adaev horse; Kushum horse; Mugalzhar horse; horse breeding; Kostanay breed; molecular genetics
The RunningLine
2024-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://submission.als-journal.com/index.php/ALS/article/view/2809
Advancements in Life Sciences; Vol 11, No 1 (2024): Advancements in Life Sciences; 18-27
2310-5380
en
Copyright (c) 2024 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/28
2014-06-13T04:44:26Z
ALS:RA
Dual properties of Nigella Sativa: Anti-oxidant and Pro-oxidant
Wajid, Nadia
Ali, Fatima
Tahir, Muhammad
Rehman, Abdul
Ali, Azib
Nigella sativa [NS] or Black seed has been used for the treatment of various disorders for centuries. Experimentally, seed extract or thymoquinone [TQ] which is the main constituent of its oil has been reported to have anti-inflammatory, antineoplastic and anticancer properties. Interestingly, the published data demonstrates that NS acts as anti-oxidant in various diseases simultaneously it behaves like a pro-oxidant for cancer cells. Here, we have summarized the dual properties of this medicinal plant. Current review is systematic, based on search from PubMed. Pubmed data indicated that NS has both anti-oxidant and pro-oxidant properties in different cell types hence should be used carefully because it acts as a cytoprotective or cytotoxic agent in inflammatory and malignant conditions respectively.
The RunningLine
2014-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/28
Advancements in Life Sciences; Vol 1, No 2 (2014): Advancements in Life Sciences; 79-88
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/28/15
oai:ojs.submission.als-journal.com:article/1031
2020-11-27T03:56:41Z
ALS:RA
Next Generation Sequencing as Rapid Diagnosis of Multidrug Resistance Tuberculosis
Messah, Anse Diana Valentiene
Pawitan, Jeanne Adiwinata
microbiology; molecular biology; genomics;
Multi-drug-resistant tuberculosis (MDR-TB) is a threat to global health. In 2018, TB related death was estimated to be more than 1.5 million cases worldwide. Conventional diagnostic method, which requires a long time to get a result, causes delays in new cases discoveries that lead to delayed therapy. Further, delayed and inadequate therapy causes an increase in the level of resistance to anti-TB drugs that may lead to death. Therefore, diagnostic tools, which can detect quickly and accurately, are highly needed. Early and timely detection is crucial for globally effective TB control, but this is not popular in developing countries, especially in Asia. Therefore, the objective of this review is to provide current information on the use of NGS as a rapid diagnostic tool for MDR-TB, especially in Asian populations, and to highlight the various MDR genes.Keywords: Next Generation sequencing; Multi-Drug Resistance; Tuberculosis; Mycobacterium tuberculosis; Rapid diagnosis
The RunningLine
2020-11-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1031
Advancements in Life Sciences; Vol 8, No 1 (2020): Advancements in Life Sciences; 30-37
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1031/464
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/2253
2024-01-08T07:56:30Z
ALS:RA
Phytotherapy in sexual disorder: overview of the most important medicinal plants effective on sexual disorders
Adeli, Omid-Ali
Prasad, KDV
Qasim almajidi, yasir
Alauldeen Khalaf, Hasan
Hjazi, Ahmed
M. Hussien, Beneen
Ali Hussein, Hussein
Naghdi, Nasrollah
Pirhadi, Mohadeseh
Fertility, Sexual disorders, Medicinal plants, Treatment
Sexual health is the result of the interaction of vascular, nervous and hormonal factors and is influenced by individual factors, interpersonal relationships, traditions governing family and society, culture and religion; these sexual disorders are one of the factors influencing marital life and it faces a challenge. The present study is a review of the most important medicinal plants effective on sexual disorders. In this study, a review of the key words "sexual function, sexual dysfunction, plant medicine, herbal medicine, treatment, fertility" was searched from Embase, Magiran, SID, Web of Science, Scopus, PubMed and Google Scholar databases. For each herb, selected published clinical trial and review articles were used. Based on the obtained results, medicinal plants such as Tribulus terrestris, Pomegranate, Red clover Lavandula angustifolia, Elaeagnus angustifolia, Pelargonium, Melissa officinalis, Quercus brantii, Ginkgo biloba, Trigonella foenum-graecum, Crocus Sativus, Zingiber officinalis, Ros Damascena, Celery seed, Date, Fennel and Carrot seed in clinical trials and Animal models are used to treat sexual disorders, Medicinal plants can effectively treat sexual disorders. Since hormone therapy has many side effects, increasing awareness of how herbs work on androgen, estrogen, and progesterone hormones and the sexual function of people will give us the knowledge that in couples' sexual dysfunctions, there are more choices for correction without using to have hormones with the aim of increasing the quality of life.
The RunningLine
Fertility, Sexual disorders, Medicinal plants, Treatment
2024-01-08
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/2253
Advancements in Life Sciences; Vol 10, No 4 (2023): Advancements in Life Sciences; 505-514
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/2253/1279
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/968
2020-06-01T03:39:43Z
ALS:RA
Alternative approaches for the treatment of Asthma and COPD: Focus on Cell-based therapies, Epigenetics, and Gene silencing approaches
Afzal, Sibtain
Ramzan, Khushnooda
Waqar, Ahmed Bilal
Asthma; COPD; Therapies; Epi-Genetics; Gene-Silencing
Despite many organized health initiatives and critically acclaimed guidelines for proper management of asthma therapy, there is still a large population of severe asthmatics having an uncontrolled disease. Severe persistent asthma, characterized by chronic airway inflammation, increased eosinophils and serum IgE is currently managed by using inhaled corticosteroids. It is quite challenging to get the best treatment guidelines for bronchial asthma in severe asthmatics, particularly in the presence of steroid resistance and the non-responsiveness to β-agonists. For that purpose, other methodologies are required to reverse the uncontrolled airway remodeling in steroid-resistant severe asthma. These advanced alternative approaches should be able to treat asthma symptoms and to improve the inflammatory conditions underlying characteristic pathological features of asthma. The current review focuses and summarizes the alternative approaches used in severe asthma patients. Agents targeting inflammatory cytokines, phosphodiesterase inhibitors, antibodies, oligonucleotides, stem cells, and target drug delivery using gene silencing, offer promise in treating severe asthma.Keywords: Asthma; COPD; Therapies; Epigenetics; Gene silencing
The RunningLine
NOT APPLICABLE
2020-06-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/968
Advancements in Life Sciences; Vol 7, No 3 (2020): Advancements in Life Sciences; 181-189
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/968/381
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1535
2023-01-21T22:12:11Z
ALS:RA
Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials
Mohammadian Amiri, Mehdi
Hameed Fayyadh, Shaimaa
Romero Parra, Rosario Mireya
Demin Al-Khafaji, Ali Hussein
Abosaooda, Munther
Darvishi, Mohammad
Emadichashmi, Sepidehalsadat
Selective cyclooxygenase-2 inhibitors, NSAIDs, renal colic pain, parecoxib, celecoxib, rofecoxib
Renal colic is an irritating condition that develops after obstruction of the ureter. Selective cyclooxygenase-2 inhibitors are types of non-steroidal anti-inflammatory drugs (NSAIDs) that have beneficial role in treatment various diseases. Hence, this systematic review summarizes the current knowledge about the role of selective cyclooxygenase-2 (COX-2) inhibitors as painkiller in renal colic pain management. The present systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. Until September 2022, PubMed/Medline, Scopus, Web of Science, and Google Scholar databases were searched using the relevant keywords including “Selective Cyclooxygenase-2 Inhibitors”, “Parecoxib”, “Celecoxib”, “Rofecoxib”, “Renal Colic Pain” and “Ureteral Colic Pain”. Of 64 identified records through database searching, 6 randomized controlled trials (RCTs) were selected for this systematic review. The sample size in RCTs were between 53 and 338. The range of subject’s age was from 18 to 69. Overall, the evidence of this review revealed that the selective COX-2 inhibitors particularly celecoxib and parecoxib could alleviate renal colic pain in most of the studies through decreasing relevant pain score. Overall, selective COX-2 inhibitors seem to be effective in alleviating renal colic pain. However, further high quality assessments are required for demonstrating therapeutic role of selective COX-2 inhibitors against renal colic pain. Keywords: Anti-Inflammatory Agents; Non-Steroidal; Renal Colic; Pain Management
The RunningLine
Selective cyclooxygenase-2 inhibitors, NSAIDs, renal colic pain, parecoxib, celecoxib, rofecoxib
2023-01-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1535
Advancements in Life Sciences; Vol 9, No 4 (2022): Advancements in Life Sciences; 446-452
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1535/841
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/545
2018-02-25T00:00:19Z
ALS:RA
WTO’s Implications on Agriculture Sector in Pakistan: Threats, Opportunities and Possible Strategies
Khan, Naeem Ullah
Ashfaq, Muhammad
Agriculture
The WTO trading system is a fact of life. This is only organization which can manage the challenges of globalization. There are both opportunities and threats for the member states in relation to different sectors of economy like agriculture. This paper examines that Pakistan has a great potential to produce and export agricultural commodities in the international markets. In order to achieve maximum benefits from the WTO, Pakistan has to take strong and immediate steps in the light of SPS and TBT Agreement that are germane with agriculture sector. In this connection Pakistan has achieved GSP+ status by European Union which gives a great opportunity to Pakistan to improve its agricultural standards and enhance its export in European agricultural markets. The paper also recommends some possible solutions to improve the agriculture standards in Pakistan. In all countries farming system play a very important role for increasing crop production and strengthen the economy of the country. Government sector should also play a vital role to educate the farmers with new planting techniques and strategic plans for the production of good quality disease free crops. Based on results and conclusion development of extension program, utilization of proper management techniques, utilization of high quality seed, government support, infrastructure and market opportunities are the dire need for farmers and agriculture of Pakistan.
The RunningLine
University of the Punjab
2018-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/545
Advancements in Life Sciences; Vol 5, No 2 (2018): Advancements in Life Sciences; 30-36
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/545/202
Copyright (c) 2018 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1380
2022-08-27T03:36:01Z
ALS:RA
Public COVID-19 vaccination acceptance: A narrative review of correlated factors
Hatami, Amirali
Hajiloo, Ahmad
Bayati, Romina
Kakavand, Peyman
Nasrollahi, Amir Hossein
Yarahmadi, Amir Hossein
Nourmohammadi, Mohammad Javad
Asadi, Heshmatollah
COVID-19, Vaccine, Acceptance, Hesitancy
Following the discovery of the first instances of COVID-19 in nations and the subsequent announcement of a “pandemic” by WHO, worldwide efforts to identify efficient methods to combat COVID-19 began. One of the most effective solutions is to carry out widespread vaccination against the virus. Despite this, some members of the community refuse to be vaccinated. The present paper reviews the potential causes and factors correlating with people's hesitation to receive COVID-19 vaccines. This article is a narrative review paper. We searched PubMed, Scopus, and Web of Science databases using COVID-19, Vaccine, Acceptance, and Hesitancy keywords. Qualitative content analysis was performed and associated predictors with public vaccination acceptance were identified. According to the study, hesitation in receiving COVID-19 vaccines, regardless of the countries, is significant among females, lower ages, lower education level, doubt about efficacy, and concerns about the safety of the vaccines, history of not receiving vaccines, especially the influenza vaccine, distrust of regional or national health officials, low level of health literacy and lack of information, fear of side effects and other complications, doubt of pharmaceutical companies and fear of lobbying, presence of chronic underlying diseases and comorbidities, lower socioeconomic status and racial or religious minorities. According to the results, several factors can influence individuals' uncertainty about COVID-19 vaccines. Given the importance of vaccinating the majority of the community to achieve mass immunity, healthcare systems should consider the vaccine acceptance rate to be a vital and substantial factor.Keywords: COVID-19; Vaccination Refusal; Review
The RunningLine
COVID-19, Vaccine, Acceptance, Hesitancy
2022-08-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1380
Advancements in Life Sciences; Vol 9, No 2 (2022): Advancements in Life Sciences; 143-150
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1380/707
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/124
2015-05-25T01:34:01Z
ALS:RA
Dengue: pathogenesis, prevention and treatment – A mini review
Hussain, Tahir
Jamal, Muhsin
Rehman, Tayyab ur
Andleeb, Saadia
Microbiology, Health and Epidemiological studies
Dengue is a threatening tropical disease which has become the cause of significant mortality, morbidity and economic burden. Dengue is an epidemic in over 100 countries, and it causes up to 25000 deaths every year. There is no specific cure available for the disease, hence fluid resuscitation is the only ultimate treatment given to patients in severe conditions. Dengue is more threatening in Southeast Asia, where it is the leading cause of deaths in children, and where all four serotypes of the dengue virus and the vector, Aedes aegypti, are endemic. In last few decades, an overwhelming increase was seen in dengue infections around the world and it is estimated that two fifths of the world's population is now at risk from dengue with the mortality rate of about 5%. To control dengue infection, combination of care measures are utilized which depends on the symptoms and severity of the fever, including oral rehydration solution or isotonic intravenous fluids and/or blood transfusions. Currently, the only effective way of preventing the dengue epidemics is eliminating the vector. This review covers pathogenesis, prevention and treatment of dengue infection.
The RunningLine
2015-05-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/124
Advancements in Life Sciences; Vol 2, No 3 (2015): Advancements in Life Sciences; 110-114
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/124/73
oai:ojs.submission.als-journal.com:article/1136
2021-08-04T10:20:57Z
ALS:RA
A Review on the impacts of Azadirachta indica on Multi-drug Resistant Extended Spectrum Beta Lactamase-positive of Escherichia coli and Klebsiella pneumonia
Al-Sarraj, Faisal MB.
Molecular Biology; Microbiology; Health and Epidemiological studies
Neem trees have long been considered the holy grail of holistic and nature-based treatments. The medicinal properties that constituents of the trees possess to range from traits that are immunomodulatory to traits combat different disease and infections such as anti-inflammatory and antibacterial effects, to insulating properties that include cardioprotective and hepatoprotective effects. The role of Extended Spectrum Beta-Lactamase positive (ESBL+) bacteria in the occurrence and recurrence of Urinary Tract Infection (UTI) infections, particularly in the Gulf region has been studied extensively. However, suggested treatment methods have had little success due to a variety of factors which include drug resistance, the inability of doctors to calculate the optimal duration for treatment, which has resulted in wrong antibiotic prescriptions, as well as lack of understanding of how UTIs work and thrive in different demographics/ populations which again, results in inappropriate antibiotic treatment of the disease. These discoveries raised the issue of professionals needing better training and education in issues to do with UTIs amongst different demographics of people. In this investigation, the medicinal and pharmacological properties of A. indica from neem leaves were assessed by studying how they affected the activity of ESBL+ bacteria, based on literature from similar studies. The goal and objective of this study were to see if ESBL+ bacteria persisted in the presence of A. Indica from leaf extract, as well as gaining an understanding of the factors that affected the persistence and subsequent treatment of the bacteria using A. indica.Keywords: Azadirachta indica; Neem; UTI; ESBL; E. coli; K. Pneumoniae
The RunningLine
2021-08-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1136
Advancements in Life Sciences; Vol 8, No 3 (2021): Advancements in Life Sciences; 228-232
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1136/553
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/2837
2024-03-06T16:36:17Z
ALS:RA
Advancements in bee venom bioactivities for current therapeutic applications: A Review
Ali, Ahmed. M. H.
Bees, as a distinguished lineage of hymenopteran insects, have undergone significant evolutionary adaptations, transitioning to a pollen-based provisioning strategy for their offspring and diverging from a reliance on prey. Within the intricate composition of bee products lies a myriad of chemicals that have garnered widespread recognition for their therapeutic and health-enhancing attributes. Bee venom, a constituent of apitherapy deeply embedded in traditional medicine with a millennia-long historical foundation, is a subject of considerable interest. Honeybees, among various bee species, manifest considerable, albeit variable, levels of antioxidant, antibacterial, and anticancer activities in their venom. This variability underscores the need for a comprehensive exploration of the diverse applications of bee venom. The present review, thus, seeks to systematically collate and analyze pertinent scientific literature, shedding light on the multifaceted roles of bee venom across various therapeutic domains. Moreover, the review evaluates the extant evidence supporting the therapeutic use of bee venom, identifying gaps and limitations within the existing body of research. By synthesizing recent advancements and critically examining the scientific landscape, this review contributes to the evolving understanding of bee venom bioactivities and offers a foundation for advancing their applications in contemporary therapeutic settings.Keywords: Apis; Antioxidant activity; Anticancer; Antimicrobial; Biological activity
The RunningLine
2024-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/2837
Advancements in Life Sciences; Vol 11, No 1 (2024): Advancements in Life Sciences; 49-55
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/2837/1411
Copyright (c) 2024 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/992
2020-09-03T04:55:48Z
ALS:RA
CRISPR/Cas9 system: Current applications and future potential in rice breeding
Bui, Anh Phu Nam
Molecular biology
Rice (Oryza sativa L.) plays a key role in human social and economic life. In order to meet the increasing needs of human food consumption, there is a constant requirement to develop rice cultivars with enhanced agricultural traits. The emerge of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (CRISPR/Cas9) system provides unprecedented opportunities in studying gene functions and creating new rice varieties with better characteristics, including improved tolerance to biotic and abiotic stresses, and increasing yield and quality. This review aims to provide details about the latest results of CRISPR/Cas9 system application on rice to obtain better adapted to environmental and commercial demands.Keywords: CRISPR/Cas9; Biotic stress; Abiotic stress; Yield; Quality
The RunningLine
2020-09-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/992
Advancements in Life Sciences; Vol 7, No 4 (2020): Advancements in Life Sciences; 225-231
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/992/423
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1646
2023-11-02T15:34:59Z
ALS:RA
Negative staining: a forgotten technique in microbiology
Alazazi, Entesar Ahmed
Ahmed, Sarfraz
Murtey, Mogana Das
Microbiology
Electron microscopy techniques have been well established as a rapid method in examining the basic characteristics of microorganisms such as bacteria as well as viruses and subsequently, exploring biological phenomena in greater detail. Though various staining techniques are available for the accurate identification of bacteria and viruses, the negative staining technique is well known for its simplicity. Negative staining is a fast technique that uses only one acidic stain and the absence of heat fixation of the sample. This stain can produce contrast images when an acidic stain does not infiltrate the cell due to repulsion between negative charges of the stain and the bacteria/viruses’ surface. However, this technique is currently fast disappearing from mainstream microscopy techniques. Thus, this short review is intended to highlight the advantages (this wasn’t discussed explicitly) and applications of the negative staining technique among laboratorians, particularly in the current, fast-paced lab environment.
The RunningLine
2023-10-23
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1646
Advancements in Life Sciences; Vol 10, No 3 (2023): Advancements in Life Sciences; 309-313
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1646/1085
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/726
2019-04-16T11:18:38Z
ALS:RA
Human Cryptosporidiosis: An insight into Epidemiology, Modern Diagnostic Tools and Recent Drug Discoveries
Zafar, Arsalan
Khan, Muhammad Kasib
Abbas, Zaheer
Abbas, Rao Zahid
Sindhu, Zia ud Din
Iqbal, Zafar
Hasni, Muhammad Shafi
Javed, Hasnain
Nadeem, Muhammad
Bajwa, Hammad Ur Rehman
Mughal, Muhammad Adnan Sabir
Yasin, Fatima
Health and Epidemiological studies; Molecular Biology; Biotechnology
Cryptosporidiosis is an emerging food and water borne zoonotic disease, which is caused by genusCryptosporidium. The first Cryptosporidium spp. was isolated from mice in 1907 and gained importance when it was found in an HIV positive patient. It usually causes self-limiting diarrhea in young children and immunocompetent patients. However, it may lead to chronic diarrhea with life threatening condition in immunocompromised patients. Other complications related to this transmittable infection may include respiratory problems, skin rashes and headache. HIV/AIDS patients are highly susceptible host for this parasite. Cryptosporidium parvum and Cryptosporidium hominis are the known pathogenic species, prevalent among humans and they are being transmitted through contaminated food and water. Usually, the diagnosis of Cryptosporidium spp. is dependent on microscopic technique in many countries, which has a low sensitivity and specificity leading to false positive results. However, for a step forward to successful epidemiological studies, advanced techniques (Serological and DNA-based) provide us the better ways of diagnosis with more sensitivity and specificity. Furthermore, no antiparasitic drug has found to be effective againstCryptosporidium spp. except Nitazoxanide which is FDA-approved and effective only when administered along with antiretroviral therapy. In this regard, present review summarizes the various epidemiological studies conducted around the globe along with modern diagnostic tools and the suitable treatment available now a days. This systemized review will help the scientists to better understand all the aspects of cryptosporidiosis at one platform which may help in designing surveillance studies through selection of sensitive diagnostic techniques. The new drugs mentioned in this review may also help to better control this parasite in humans, especially immunocompromised individuals.
The RunningLine
Punjab AIDS Control Program, Health Department, Government of Punjab
2019-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/726
Advancements in Life Sciences; Vol 6, No 2 (2019): Advancements in Life Sciences; 60-70
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/726/267
Copyright (c) 2019 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1098
2023-01-21T22:12:11Z
ALS:RA
Mathematical Understanding of Sequence Alignment and Phylogenetic Algorithms: A Comprehensive Review of Computation of Different Methods
Saif, Rashid
Nadeem, Sadia
Khaliq, Alishba
Zia, Saeeda
Iftekhar, Ali
Pairwise sequence alignment is one of the ways to position two biological sequences to identify regions of similarity that may suggest the functional, structural and evolutionary relationship among proteins and nucleic acids. There are two strategies in pairwise alignment: local sequence alignment (Smith Waterman algorithm) and global sequence alignment (Needleman Wunsch algorithm). In the prior approach, two sequences that may or may not be related, are aligned to find regions of local similarities in large sequences, whereas in the later one, two sequences of same length are aligned to identify their conserved regions. Moreover, similarities and divergence between biological sequences also has to be rationalized and visualized in the form of phylogenetic trees, so the dendrogram construction approaches were developed and divided into distance-based and character-based methods. In this review article, different algorithms of sequence alignment and phylogenetic tree construction were meditated with examples and compared by looking into the background computation for the better understanding of the algorithms, which will be helpful for molecular biology, computational sciences and mathematics/statistics novices. Phylogenetic trees are constructed through various methods, some are computationally robust but does not provide precise evolutionary insight, whereas some provide accurate evolutionary understandings, but computationally exhaustive and cumbersome. So, there is a need to understand the implicit mathematics and intricate computation behind the dendrogram construction for improving the existing algorithms and developing new methods. Keywords: Local sequence alignment; Global sequence alignment; UPGMA; Neighbour joining; Fitch Margoliash; Maximum-Parsimony; Maximum-Likelihood
The RunningLine
2023-01-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1098
Advancements in Life Sciences; Vol 9, No 4 (2022): Advancements in Life Sciences; 401-411
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1098/837
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/270
2017-02-27T22:34:07Z
ALS:RA
A report on asthma genetics studies in Pakistani population
Ghani, Muhammad Usman
Sabar, Muhammad Farooq
Shahid, Mariam
Awan, Farheena Iqbal
Akram, Muhammad
Molecular Biology; Biotechnology; Asthma Genetics
Pakistan is globally sixth most populous, economically developing south Asian country with tremendously increasing trend of urbanization. This increase in urbanization along with consanguineous marriages trend in Pakistani nationals might contribute as most important factors of increasing asthma prevalence.Up-till now, a few studies related to asthma genetics have been conducted in Pakistan. These studies suggest that the SNP variants like (rs2569190, rs2569191), (rs2243250, rs2227284), (rs1800896), (rs1881457, rs20541, rs1800925), (rs2280091, rs2787094, rs528557), (rs1131882) in CD14, IL-4, IL10, IL-13, ADAM33 and TBXA2R genes respectively and the SNPs (rs3816470, rs6503525, rs3859192, rs12603332) on chromosomal region 17q21 are significantly associated in Pakistani population whereas the haplotype “CCTCAG" of SNPs (rs12936231, rs7216389, rs7216558, rs9894164, rs1007654 and rs7212938) in 17q21 and ‘AAGTCG’ of SNPs (rs2280089, rs2280090, rs2280091, rs44707, rs528557, and rs612709) in ADAM-33 region are protective factor against asthma susceptibility.These studies will definitely contribute in understanding genetic basis of asthmatic complications in Pakistan and large population cohort size and sub-ethnic studies in future will give more meaningful conclusions to predict possible asthma susceptible genomic variants in sub-ethnic and general population of Pakistan.
The RunningLine
2017-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/270
Advancements in Life Sciences; Vol 4, No 2 (2017): Advancements in Life Sciences; 33-38
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/270/152
Copyright (c) 2017 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1208
2022-07-05T10:44:30Z
ALS:RA
A review on Aluminum phosphide (Rice Tablets) Poisoning; From Exposure to the Applicable and New Strategies of Clinical Management
Manouchehri, Aliasghar
Ghareghani, Shiva
Shamaei, Shabnam
Nilechi, Maede
Bossaghzadeh, Fatemeh
Rice tablets (especially aluminum phosphide) as a solid fumigant pesticide is one of the major areas of interest within the field of pesticide poisoning due to high fatality. It is commonly used in grain storage places including silos, warehouses, and grain transporting systems such as ships to control damages of pests and rodents. Unfortunately, it is considerably consumed for suicidal purpose in developing countries because of the ease of access. Aluminum phosphide (ALP) has been conceived as the most mortal one among others and accounts for many deaths each year. ALP toxicity is associated with phosphine gas liberation which is highly toxic and may cause various toxicities in all body organs, especially in cardiovascular and respiratory systems. As there is no certain antidote to prevent human's death, hence having thorough information about this pesticide is required. Thus, in this article physiochemical features of rice tablets, various toxicological, clinical/pathological impacts of ALP on human body and also applicable and new strategies of its managements have been highlighted. Eventually, gathering all published information about ALP intoxication till date demonstrated that restricted preventative measures plus early and improved management protocols can limit the organ injuries and mortality.Keywords: Phosphine; Rice tablet; Aluminum phosphide; Human poisoning; Pesticide; Toxicity of ALP; Management strategies
The RunningLine
2021-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1208
Advancements in Life Sciences; Vol 8, No 4 (2021): Advancements in Life Sciences; 326-332
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1208/665
https://submission.als-journal.com/index.php/ALS/article/downloadSuppFile/1208/337
https://submission.als-journal.com/index.php/ALS/article/downloadSuppFile/1208/338
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/71
2015-02-25T00:00:25Z
ALS:RA
Micro Propagation in Advanced Vegetable Production: A Review
Butt, Shahid Javed
Varis, Servet
Nasir, Idrees Ahmed
Sheraz, Suman
Shahid, Azka
Biotechnology; Agriculture
Micro propagation is a fast method of plant propagation that has a great potential to develop high quality as well as disease-free plants. Advancements in this field have led to the development of several techniques for rapid multiplication and improvement of a wide range of horticultural crops and their production systems. Micro propagation includes three types of vegetative propagation, 1) somatic embryogenesis, 2) adventitious shoot production and 3) axillary shoot production, which provide excellent opportunities for successful vegetable crops production. In Capsicum genera, annuum-chinense-frutescens complex have been made with white flowers and small yellow seeds. A number of experiments have also been done to demonstrate the influence of hypocotyl explant orientation on shoot bud induction in Capsicum spp. Sweet potato cuttings when grown in vitro with Florialite gives greater percentage of survival. Similarly, in vitro layering of gourds; a modification in micro propagation methods become more advantageous as it produces single shoot rather than multiple shoots. Likewise, an immobilized culture system of obtaining torpedo-stage embryos of carrots of uniform size and higher tuber yield with rapid multiplication rate for potato were also introduced by micro propagation techniques.
The RunningLine
2015-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/71
Advancements in Life Sciences; Vol 2, No 2 (2015): Advancements in Life Sciences; 48-57
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/71/60
oai:ojs.submission.als-journal.com:article/1020
2021-08-04T19:18:33Z
ALS:RA
Stevia rebaudiana: A Bibliometric Analysis from 1966-2019
Nasir, Saima
Ahmed, Jamila
bibliometrics; plant sciences; food sciences
This study has been carried out to analyze research papers published on Stevia rebaudiana during 1966-2019 using a bibliometric approach. The data is mined from the Web of Science Core Collection, returning 1835 articles on the topic for analysis. The study documents most productive countries and authors delved into Stevia research. India appears to be the most productive country, followed by USA. The top-cited articles, top-organizations and funding agencies, and journals with most publications on subject are also identified. The analysis shows an increasing trend for research on Stevia during recent years with an Annual Percentage Growth Rate of 1.29 and the number jumped from only 03 publications in 1966-1971 to 1000 in 2014-2019. Pakistan has a comparable global share of 2.84% on Stevia research but further attention on research is needed in this field apprehending the commercial and health potential of this plant and considering the status of Pakistan as an agrarian country.Keywords: Stevia rebaudiana; Economic potential; Research productivity; Bibliometric
The RunningLine
None
2021-03-13
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1020
Advancements in Life Sciences; Vol 8, No 2 (2021): Advancements in Life Sciences; 195-201
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1020/532
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1608
2024-01-08T07:56:30Z
ALS:RA
An overview of the uses of propolis for oral health
Gholamine, Babak
R. Alwaily, Enas
Fakri Mustafa, Yasser
Taher Habash, Ruqayah
Naghdi, Nasrollah
Jalalvand, Masumeh
Papi, Sepideh
Khodaei, Seyedeh Mahsa
Propolis is a gummy agent exploited from bees, which has anti-inflammatory, antibacterial, anti-allergic, wound healing, antidiabetic, and antiviral effects against various injuries and diseases. It also produces antifungal, antitumor and local anesthetic effects. The aim of the review was to review research findings on the role of propolis in oral health. This study was conducted by reviewing published articles on the use of propolis in oral health. To this end, Persian electronic databases such as Google, SID and Magiran as well as English databases such as PubMed and WOS were searched for articles published from 1979 onwards, 140 papers were retrieved, 21 articles were excluded, and 119 articles were included in final review. So far, propolis has been studied for the treatment of surgical wounds, intracanal irrigation, inhibition of the decay process, treatment of periodontitis and dentin hypersensitivity, and potential antifungal and antibacterial activities in the canal with a mostly satisfactory efficacy. Propolis has been reported to improve surgical wounds and produce anti-decay, anti-dentin hypersensitivity and anti-aphthous ulcer properties, and to be useful as a tooth-storing medium after tooth extraction, an intracanal irrigant and a mouthwash. substances highly useful properties of propolis, it can be argued that in the future, the substance will play a substantial role in dental science are necessary to isolate its compounds and identify their beneficial effects.
The RunningLine
Propolis, Dentistry, Honeybee, Oral health, Bee glue
2024-01-08
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1608
Advancements in Life Sciences; Vol 10, No 4 (2023): Advancements in Life Sciences; 515-524
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1608/1311
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/823
2020-09-03T04:55:48Z
ALS:RA
The role of opioid and nitrergic systems in dual modulation of seizure susceptibility
Khan, Muhammad Imran
Shah, Farid Ullah
Wahab, Abdul
Nikoui, Vahid
Dehpour, Ahmad Reza
Molecular Biology; Genomics
Epilepsy is a chronic disorder presented by recurrent episodes of seizures and affect worldwide individuals. The underlying mechanism of seizure is still elusive. Hence, there is still a need to determine the contribution of various systems in neurobiology and treatment of seizure. Evidence shows that opioid and nitrergic systems within the brain interact to modulate various physiological and pathological conditions including memory, pain, reward, addiction, depression, and seizure. Various studies revealed that diverse dose of opioids such as morphine has dual modulation in seizure susceptibility. For instance, it is reported that morphine at lower doses (0.5, 1, and 3 mg/kg) exerts an anticonvulsant effect in experimental seizure models, whereas at higher doses (15, 30, and 60 mg/kg) it could exacerbate the seizure. Similarly, nitrergic system has also been observed to possess dual effects in modulating the seizure threshold. Therefore, understanding of opioidergic and nitrergic systems interaction in seizure seems important to achieve the successful goal of seizure management. This review aimed to clarify and provide insight into how opioidergic and nitrergic systems interact in brain and mediate seizure behavior.Keywords: Opioids; Nitric oxide; Seizures; Morphine
The RunningLine
2020-09-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/823
Advancements in Life Sciences; Vol 7, No 4 (2020): Advancements in Life Sciences; 193-201
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/823/408
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1209
2023-04-14T10:29:04Z
ALS:RA
Emergence of SARS-CoV-2: Insight in genomics to possible therapeutics
Saeed, Saira
Ahmad, Shahbaz
Tareen, Aatikah
Iqbal, Atia
Epidemiological studies; Genomics; Molecular Biology
Rising of a new virus from city of Cathay, responsible for 2019 global pandemic is caused by SARS-CoV-2marked as a great threat for populations. The member (CoV-2) from vast family of Covid virus with single- stranded RNA spread to over 216 countries and billions of individuals died all around the globe. Regardless of all strict standard operating procedures, special care and therapies, SARS-CoV-2 mutating its genomic structure and leads to shutting the world. While different therapeutic approaches face problems due to the complexity in pathogenicity mechanism of CoV-2 and its variants. Mechanism of action, genome analysis, transmission, development of broad-spectrum antiviral medications and SARS-CoV-2 vaccines have been reported which are essential for future directions to control this pandemic. Here, in this review, these domains were discussed to highlight the genome structure pathophysiology, immune response, multiple diagnostic methods, and possible treatment strategies. This review deliberates the methodologies for creating practical vaccinations and treatment cocktail to manage this eruption.Keywords: SARS-CoV-2; Genetics; Epidemiology
The RunningLine
2023-04-14
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1209
Advancements in Life Sciences; Vol 10, No 1 (2023): Advancements in Life Sciences; 5-16
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1209/929
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/581
2018-05-25T07:10:10Z
ALS:RA
Annotation and curation of hypothetical proteins: prioritizing targets for experimental study
Naveed, Muhammad
Chaudhry, Zoma
Ali, Zeeshan
Amjad, Mahnoor
zulfiqar, Fizza
numan, Ali
Genomics; Genome; Health and Epidemiological studies
Completely sequenced organisms have some uncharacterized proteins that are gene-encoded products. These proteins can be predicted through in-silico approaches and their biological activities are not proved by experimental evidence and known as hypothetical proteins (HPs). These proteins are important due to their excessive involvement in different cellular and signaling pathways. Structural and functional characterization of HPs reveal crucial roles in microorganisms, especially in pathogens related to human diseases. Here, we discussed all possibilities of in-silico analysis tools and other recently reported methods for hypothetical protein characterization and biomedical applications, including drug and vaccine development. Different methodologies, including meta-proteomics have been used to study protein expression by identification of HPs and comparative genomics have also come under observation due to the emergence of evolutionary study among different organisms. Structural characterization of proteins acts as a base for their functional prediction, novel drug target identification for disease treatment, vaccine production and sero-diagnosis. HPs have played major roles in different vital phenomenon for life including host adaptation, wound healing and chemotaxis. In the current era of drug and antibiotic resistance, HPs can be novel targets to treat related diseases. Identification and characterization of most HPs are under observation and will be the most promising genomic and bioinformatics techniques in structure-based drug designing and vaccine production in future.
The RunningLine
N/A
2018-05-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/581
Advancements in Life Sciences; Vol 5, No 3 (2018): Advancements in Life Sciences; 73-87
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/581/222
Copyright (c) 2018 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1414
2022-11-05T04:22:56Z
ALS:RA
Biosecurity and Biosafety concerns of Research and diagnostic Laboratory under International Guidelines
Huda, Noor-ul-
Shahid, Fabiha
Iftikhar, Iqra
Rehman, Hafiz Muhammad
Javaid, Shehla
Fatima, Mubeen
Rehman, Iqra
Babar, Momal
Biochemistry, Health and Epidemiological studies
Currently, academic research labs and diagnostic laboratories are facing a serious issue of biosecurity and biosafety globally. The high rate of mutations and continuous new emerging infectious diseases with the risk of bioterrorism demands that each lab personnel share equal responsibility for biosecurity & biosafety at their work. The primary job of government authorities is to implement a well-organized detection system and limit the spread of hazardous biological agents by providing a biologically safe setting for lab scientists and for the common man in communities and institutes. The safety of lab personnel, lab environment, and pathogens depends on effective and safe laboratory working and pathogen handling which determines the reliable and accurate results of laboratory experiments. The aim of this article is to address the basic components of laboratory biosafety, laboratory biosecurity, and laboratory management. Further DURC (dual-use research of concern) deals with the commencement of lawful reasons to generate information, knowledge, technology, and products that are used for either harmful or beneficial purposes. The precautions are taken to ensure laboratory biosecurity and biosafety should be a part of the laboratory safety policy manual for guidance and implementation for a safe laboratory environment.Keywords: Antioxidants; tomato; lycopene; β-carotene; reactive oxygen species (ROS)
The RunningLine
2022-08-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1414
Advancements in Life Sciences; Vol 9, No 2 (2022): Advancements in Life Sciences; 151-156
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1414/787
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/121
2015-08-24T14:34:28Z
ALS:RA
Effective treatment strategies against Ebola virus
Yaqoob, Amina
Shehzad, Umara
Ahmad, Zarnab
Naseer, Nadia
Bashir, Saliha
Molecular Biology; Molecular Virology
Ebola virus (EBOV), a member of order Mononegavirales is most famous for causing the endemics of hemorrhagic fever in different countries of the world. Various effective treatment for EBOV are available presently but different clinical trials and experimental studies on animal models are ongoing for this purpose. Results from different studies showed that selective vaccines and therapeutic drugs have potential to interfere the viral life events within host cell in order to inhibit its replication. Various pre-clinical trials in this regard are proved successful on non-human primates (NHPs) and found to be significant in inhibiting EBOV infections. It is the need of hour to develop effective vaccines against Ebola virus to combat this problem as soon as possible. The present article is a brief review on potential treatment strategies against Ebola virus.
The RunningLine
Centre of excellence in Molecular biology. University of the Punjab
2015-08-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/121
Advancements in Life Sciences; Vol 2, No 4 (2015): Advancements in Life Sciences; 176-182
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/121/85
oai:ojs.submission.als-journal.com:article/1048
2021-08-04T10:20:57Z
ALS:RA
Contribution of GJB2 gene mutations to hearing loss in Pakistani population – A Narrative Review
Ali, Ejaz
Hussain, Nageen
Molecular Genetics
Pakistan has a unique population for the study of recessive genetic diseases due to a higher consanguinity rate. Hearing impairment is the loss of hearing normal sounds, and it is a common sensory disorder that affects more than 466 million people worldwide. Immuno-genetic and other environmental factors like loud noises, drug usage, and viral infections are the causes of hearing loss. Hearing loss is categorized into a syndromic hearing loss (70%) and non-syndromic hearing loss (30%). GJB2 mutations are one of the main causes of hearing loss in different populations, including Pakistan. The GJB2 gene encodes a gap junction protein involved in the homeostasis of the inner ear through the recycling of potassium ions. The prevalence of GJB2 mutation in the Pakistani population varies from 6.1 to 9.2%. The most common mutations found in the Pakistani population are 71G>A (p.(Trp24*), 231G > A (p. Trp77*), c.35delG (p. Gly11Leufs24*),c.355G>T (p. Glu119*) 457G > A (p.Val153Ile), 598G > A (p.Gly200Arg), 439G > A (p.Glu147Lys), c.377_378insATGCGGA (p.Arg127Cysfs*85). c.1055C>T (p. Pro352Leu), c.6202A>C p.(Thr2068Pro), c.2496_2496delC p.(Tyr832*) and c.355G>T p.(Glu119*).Keywords: Gap junction protein, GJB2 mutations, Hearing loss.
The RunningLine
N/A
2021-08-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1048
Advancements in Life Sciences; Vol 8, No 3 (2021): Advancements in Life Sciences; 217-220
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1048/555
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1647
2024-03-06T16:36:17Z
ALS:RA
The Concept of Chloroplast Transformation; Its Relevance Towards Food Security
Tabassum, Bushra
Yousaf, Iqra
Adeyinka, Olawale Samuel
Khalid, Rida
Khan, Anwar
Bioyechnology, Agriculture
The world population is expected to reach an estimated 9.2 billion by 2050 which means up to 70% increase in food production would be needed to feed the world. Moreover, climate changes pose yet another challenge to global food security. Genetic engineering is playing its role in modern agriculture to overcome food security challenges but for better crop production more biotechnological advances are required. Chloroplast genetic engineering provides a better alternative to nuclear genetic engineering due to its properties of precise transgene insertion through homologous recombination, lack of epigenetic changes and high transgene expression. We reviewed the fundamentals behind chloroplast transformation and divulge its various applications in nutritional enhancement and agricultural stress management. Furthermore, we provide recent efforts of Ribonucleic Acid interference (RNAi) technology in the transplastomic transformation towards insect-specific and environmentally friendly control measures. We envisage that targeted chloroplast genome editing could be a game changer in the future application of chloroplast transformation.Keywords: Agricultural stress management; Chloroplast transformation; Genome editing; RNA interference; Transgenic crops
The RunningLine
International Foundation for Science grant (No C/6257-1)
2024-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1647
Advancements in Life Sciences; Vol 11, No 1 (2024): Advancements in Life Sciences; 28-39
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1647/1409
Copyright (c) 2024 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1024
2020-11-27T03:56:41Z
ALS:RA
Medicinal Properties of Arabica coffee (Coffea arabica) Oil: An Overview
ALAsmari, Khalid Mushabbab
Abu Zeid, Isam M
Al-Attar, Atef M
Phytochemistry
Coffee is one of the massive tropical crops in developing countries and historically understudied in subjects of crop nutrition and administration. Arabian coffee (Coffea arabica) plant belongs to the genus Coffea in the Rubiaceae family. It is known as the most widely recognized Coffea species created comprehensively summing up to over 75% of the all-out Coffea creation. Its compounds are a complex mixture of different chemicals that have many health benefits. The usage of various parts of a coffee plant, along with its oil is verified for the manufacturing of ancient medicines that helped in curing a number of ailments. These traditional uses were scientifically proven by many studies including psychoactive responses, neurological and metabolic disorders. Coffee oil consists mainly of triglycerol and fatty acids along with antioxidants. It also possesses some biologically active fatty acids that are anti-cancerous, anti-inflammatory, anti-bacterial, anti-diabetic and anti-atherosclerotic in nature. This paper provides the medicinal properties and scientific review of Arabica coffee Oil.
The RunningLine
No Funding source
2020-11-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1024
Advancements in Life Sciences; Vol 8, No 1 (2020): Advancements in Life Sciences; 20-29
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1024/463
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1845
2023-11-02T15:34:59Z
ALS:RA
Diseases of the Neuroacanthocytosis Group: A Systematic Review of Clinical Cases and Difficulties in their Diagnosis
Spesivtseva, Anna
Gvarzhdets, Natalya
Autlev, Kazbek
Kruchinin, Evgeny
Kuznetsov, Ivan
This systematic review examines diseases within the neuroacanthocytosis group, including chorea-acanthocytosis (ChAc), McLeod syndrome (MLS), Huntington's-like type 2 disease (HDL2), and other neurodegenerative disorders. The objective of this review is to provide a comprehensive overview of the clinical manifestations, diagnostic challenges, and current understanding of these rare hereditary diseases. Each nosological unit from this group is caused by various genetic mutations and has a different type of inheritance, pathogenetic changes, and clinical picture. Due to the rarity and relatively little knowledge of the pathogenetic foundations of these diseases, their diagnosis is a difficult task, and their treatment, as a rule, is only symptomatic
The RunningLine
2023-09-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1845
Advancements in Life Sciences; Vol 10, No 3 (2023): Advancements in Life Sciences; 335-340
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1845/1119
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/523
2019-05-26T05:27:07Z
ALS:RA
An Overview of Genome-Wide Association Study for Genetics Novices: A Review
Tahir, Hafsa
Ejaz, Aniqa
Mahmood, Tania
Riaz, Sidra
Saif, Rashid
Molecular genetics, Bioinformatics
SNP chip-based genome-wide association studies (GWAS) is an inspiring and fast scanning method for mapping variations within the genome and associating them with specific diseases/trait. This association information has enhanced the chances of improvement in disease diagnosis, understanding the causative variants locations and associated gene hunting strategies. GWAS have laid foundation of an era in which both personalized medicine and pharmacogenomics would be reinforced along with better understanding of functional genomics aspects of modern molecular genetics. Since the advent of first GWAS in 2002, thousands of genome wide association studies have been published which have proven GWAS a successful methodology in identifying significant variants in disease/trait association but application of GWAS outcomes to clinical settings demands more evaluation for validity. Here, we have divided the GWAS approach into various aspects including history, development, analysis strategies, approaches, current scenario and different applications with brief description of major methodologies being used in scientific community to get associated SNP hits and narrowing down the search by functional variant filtration involved in subject disease, traits or physiological condition.Keywords: GWAS, Genetic Association, Linkage Disequilibrium, HapMap, PLINK
The RunningLine
NA
2019-05-26
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/523
Advancements in Life Sciences; Vol 6, No 3 (2019): Advancements in Life Sciences; 88-96
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/523/279
Copyright (c) 2019 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1467
2023-01-21T22:12:11Z
ALS:RA
The Contagious Nature of SARS-CoV-2 Omicron Variant and Vaccine Efficacy
Khan, Shahab Ahmad
Ahmad, Ijaz
Khan, Wajid
Khan, Hayat
., Abdullah
Akbar, Sadiq
Microbiology, Health and Epidemiological studies
Background: Since the first COVID-19 outbreak, variants of SARS-CoV-2 have continued to dominate the global population. The repeated waves of emerging variants, each replacing the previous one with a greater rate of transmissibility and mutations, are the primary cause of the global pandemic. Public health concerns dramatically rose when a highly mutated variant (VOC) omicron (B.1.1.529) emerged in late 2021. omicron has more than 50 mutations, and over 30 mutations are in their spike protein that contributes to the virologic characteristics of the variant. Omicron is more contagious than previously reported SARS-CoV-2 strains and can re-infect people who have already contracted other SARS-CoV-2 infections. The variant has acquired a unique immune escape mechanism against monoclonal antibodies and vaccines. Currently, no therapeutic drug or vaccine is specifically available to prevent omicron infection and sublineage emergence. Method: The review was designed to search the recent research and literature and compile the most pertinent data on the virologic characteristics of the variant of concern. Result: The study reviewed and discussed the present prevalence, infectivity, dominance, immune evasion, therapeutic options, vaccine efficacy, and the future prospect of the omicron variant. Conclusion: Omicron variant has become a global public health concern due to the emergence of highly mutated sublineages. Developing variant-specific therapeutic drugs or vaccines is desirable to prevent the spread of these contagious variants globally.Keywords: COVID-19, SARS-CoV-2, Omicron variant, Vaccine efficacy, Immune evasion.
The RunningLine
2023-01-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1467
Advancements in Life Sciences; Vol 9, No 4 (2022): Advancements in Life Sciences; 429-436
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1467/839
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/477
2017-08-25T01:03:45Z
ALS:RA
Plant genome editing using engineered nucleases and success of CRISPR/Cas9 system
Sajid, Moon
Hassan, Zohaib
Sehrai, Ghulam Hussain
Rana, Muhammad Adeel
Puchta, Holger
Rao, Abdul Qayyum
Biotechnology;
Development of new plant breeding techniques have facilitated easy manipulation of plants at genetic level. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein9 (Cas9) system is a valuable addition in programmable nucleases. The CRISPR/Cas9 system uses an RNA component to recognize a target DNA sequences and it has shown promising results with respect to simultaneous editing of multigenic plant traits. In this review, components of CRISPR/Cas9, their construction and its methods of delivery to plant cells are analyzed. Variation in nucleotide sequence of the protospacer adjacent motif, codon optimization and progress in web-based bioinformatic tools, will make CRISPR/Cas9 systems more efficient for plants. Development and optimization of protocols to efficiently target all plant species is still under development. Along with this, methods to inspect induced mutation and efficiency of the system have also been reviewed. Auxiliary improvements and understanding are still required to expand the CRISPR/Cas9 systems to target complex genome architectures and epigenetic elements.
The RunningLine
2017-08-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/477
Advancements in Life Sciences; Vol 4, No 4 (2017): Advancements in Life Sciences; 127-136
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/477/176
Copyright (c) 2017 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1179
2022-06-05T04:32:08Z
ALS:RA
Appraisal of various approaches to produce biohydrogen and biodiesel from microalgae biomass
Zeb, Liaqat
Shafiq, Muhammad
Ahmad, Munir
Khan, Asaf
Ahmad, Dawood
Mehmood, Arshad
Biotechnology;Biofuels;Microalgae;
The need for fossils fuels, including oil, coal and natural gases, has increased dramatically due to a vast expansion in human population and economic growth. The emission of greenhouse gases from fossil fuels leads to disastrous alterations in the earth's climate. In a few decades, fossil fuels will run out because of their non-renewability. Many researchers are motivated to develop new renewable energy sources to replace fossil fuels. Recent research has identified microalgae as a promising resource for the production of biohydrogen and biodiesel. Biohydrogen production affords an environmentally friendly and sustainable approach to generate clear, clean and reliable energy from renewable resources. Green microalgae use sunlight to convert water molecules into oxygen and molecular hydrogen under special conditions. Microalgae have also been reported as a promising feedstock for biodiesel production, as biodiesel is considered the best alternative to petroleum-derived diesel. In the present review, the production of biohydrogen and biodiesel from microalgae through different methods, including indirect and direct biophotolysis, transesterification and lipid synthesis, enhancement approach, is briefly discussed. This article is critical for exploring ideas for future research that can be applied in the commercialization of biohydrogen and biodiesel from microalgae biomass.Keywords: Biohydrogen; Biodiesel; Biophotolysis microalgae; Transesterification
The RunningLine
NA
2022-05-29
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1179
Advancements in Life Sciences; Vol 9, No 1 (2022): Advancements in Life Sciences; 01-12
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1179/659
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/105
2015-02-25T00:00:25Z
ALS:RA
Defense strategies of cotton against whitefly transmitted CLCuV and Begomoviruses
Khan, Muhammad Azmat Ullah
Shahid, Ahmad Ali
Rao, Abdul Qayyum
Shahid, Naila
Latif, Ayesha
Din, Salah ud
Husnain, Tayyab
Molecular Biology; Virology; Plant biotechnology; Plant Physiology
Cotton leaf curl virus (CLCuV) is economically important monopartite Geminivirus which is transmitted by whitefly in persistent circulative manner. In Pakistan, CLCuV causes severe damage to Gossypium hirsutum whereas G. arboreum is resistant to this virus. A total of 86 articles were included in this study that were searched through web of knowledge, web of science and google scholar by using the keywords of cotton, CLCuV, waxes, Begomoviruses and transgenic techniques used against Begomoviruses in plants. Various transgenic strategies i.e., pathogen derived resistance (with and without protein expression) and non - pathogen derived resistance have been adopted to control this virus or its vector. Beside these, some natural defense mechanisms of plant also protect it against the vector. The cuticular waxes make the insects’ attachment difficult to plant surfaces and act as a physical barrier. The cuticular waxes in G. arboreum act as first line of defense against whiteflies and thus CLCuV. Some other defense strategies may involve hindering the insect movements or depriving it from food due to thick waxy layer. Biotechnological strategies against various Begomoviruses including CLCuV were found successful in some crops except cotton. Whereas, the natural defense strategies in G. arboreum i.e., long trichome or presence of inorganic salts with increased concentration of waxes, provide good defense strategy against whiteflies, CLCuV and other pathogens.
The RunningLine
2015-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/105
Advancements in Life Sciences; Vol 2, No 2 (2015): Advancements in Life Sciences; 58-66
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/105/55
oai:ojs.submission.als-journal.com:article/1073
2021-08-04T19:18:33Z
ALS:RA
Narrative Review: Use of Competent Stimulating Peptide in Gene Transfer Via Suicide Plasmid in Streptococcus pneumoniae
Baig, Atif Amin
Zulkiflee, Nor Aina Shafiqah Binti
Hassan, Muhammad
Rohin, Mohd Adzim Khalili Bin
Johari, Mohd Khairi Bin Zahri
Latif, Ahmad Zubaidi Bin A.
Khan, Muhammad Umer
Simbak, Nordin Bin
Natural competency for genetic transformation of Streptococcus pneumoniae causes the emergence of novel or non-vaccine preventable pneumococcal serotypes. This phenomenon has become a global concern as it can spread quickly in the population through inhalation and close contact. The colonisation of S. pneumoniae at the upper respiratory tract can either become commensal or pathogenic. Once the bacterium invades into the body system, it will secrete its toxin and virulence protein to facilitate the invasion. Besides, S. pneumoniae can undergo natural biological transformation via uptake of exogenous DNA by horizontal gene transfer for integration and recombination of the genome. S. pneumoniae natural transformation is aided by competence-stimulating peptide (CSP) that induces the competence of bacteria. Natural transformation cascade of S. pneumoniae via CSP is triggered in the presence of conserved 17-amino acids peptide which is regulated and encoded by comC, comD and comE operon, where comC is responsible in secreting precursor CSP. Nowadays, researchers transforming S. pneumoniae by inserting the mutated S. pneumoniae gene through a vector, suicide plasmid. Suicide plasmids such as pID701, pAUL-A and pVA891 can be transferred but cannot replicate in the bacteria. Homologous recombination process occurs once the mutated gene of suicide plasmid is integrated with wild-type S. pneumoniae. Previous studies had used the transformation of suicide plasmid into S. pneumoniae as it can integrate with host DNA at specific insert for gene transfer. But there is no evidence on the role of CSP in horizontal/gene replacement via suicide plasmid in Streptococcus pneumoniae. This narrative review's scope as per defined purpose statement is to relate and recommend the use of competent stimulating peptide in efficient horizontal gene transfer via suicide plasmids in Streptococcus pneumoniae.Keywords: Streptococcus pneumoniae transformation; CSP-based transformation; Gene transfer via suicide plasmid; Genetic exchange; Competence-stimulating peptide
The RunningLine
2021-03-13
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1073
Advancements in Life Sciences; Vol 8, No 2 (2021): Advancements in Life Sciences; 211-216
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1073/525
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1338
2024-01-12T19:22:10Z
ALS:RA
Overdominance in livestock breeding: examples and current status
Bui, Anh Phu Nam
Tam, Trinh Lam Hoang
Phuong, Pham Thi
Linh, Nguyen Thuy
Molecular biology
Recent data have revealed that genetic variation could be attributed to overdominance, or heterozygote advantage. However, genomic survey showed that only a small number of genes that have polymorphisms maintained by overdominance which is consistent with many published papers. Google Web, Google scholar, NCBI Databases and OMIC Tools were used to obtain data for this review paper. Different key words were used to retrieve the required research articles and bioinformatics-based information, such as “overdominance’’ and “overdominance in animals’’. Research papers used for this review were published over the last 10 to 15 years and information regarding overdominance in livestock was considered for current review. It is hoped that in the future, more loci with overdominance will be discovered. In this review, we will illustrate eight examples of overdominance in livestock. We also want to emphasize that given a low number of reported cases in overdominance, it does not reflect the unimportance of heterozygote advantage in adaptive functions.
The RunningLine
2023-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1338
Advancements in Life Sciences; Vol 10, No 4 (2023): Advancements in Life Sciences; 525-529
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1338/1313
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/957
2020-09-03T06:25:14Z
ALS:RA
Potential of Camel Dung as Promising Organic Manure in Saudi Arabia
Abdel-Rahman, Eitimad Hashim
Alzahrani, Fawzia Saleh
Sulieman, Abdel Moneim El Hadi
Biology-zoology-taxonomy-ecology-biodiversity and environmental studies
Energy consumption in Saudi Arabia (KSA) is growing rapidly due to the high living standards, population growth and urbanization rates. KSA has planned for the development and use of biomass renewable energy sources, which are available abundantly, carbon-neutral and climate mitigation source. The main purpose of this review article is to analyze and discuss the challenges and opportunities of Camel Manure (CM) as an effective management of the livestock waste, and its potential development in the management of biomass and energy technology (BETM). The trends in the camel population growth projected at approximately 1.6 million camels in the Arab Peninsula and approximately 53% of the total in KSA with untapped manure falling along with the Municipal Solid Waste (MSW) making them ideal for energy extractions and applications in remote and rural areas. Research is needed to assess camel manure resources (supply and demand), the technology scope for economic, energy capacity and application evaluation to fill energy potential and challenges applications for KSA.Keywords: Camel Manure; Biomass; Bioenergy; Manure Technology; KSA
The RunningLine
Hai'l University, Faculty of Science
2020-09-02
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/957
Advancements in Life Sciences; Vol 7, No 4 (2020): Advancements in Life Sciences; 202-207
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/957/424
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1481
2023-04-14T10:29:04Z
ALS:RA
The role of bacteriophages transferring virulence factors to Escherichia coli species
Alotibi, Ibrahim
Bacteriology,gram negative bacteria,phage
Bacteria develop in order to adapt to new surroundings, colonize new niches, and become pathogenic. The presence of mobile genetic elements MGEs in E. coli can be increasing the genome size of a pathogenic strain by up to 1 Mb when compared to a commensal strain. Phage satellites make up one subset of MGEs they are linked to specific temperate phages, named as helper phages, which parasite bacteria for their own induction. In fact, various pathogenic E. coli differ in the presence of a subset of genes produced by MGEs that are crucial in hijacking host cell machinery and subverting host responses. Phages not only provide genetic variability through prophage integration, they can also mediate horizontal genetic transfer HGT within bacterial populations through the transfer of either bacterial DNA or other MGEs, such as phage satellites. The phage-mediated transfer of bacterial DNA is known as transduction and plays a crucial role in bacterial biology, diversity and evolution. Recently, it has been noticed that phage transduction occurs at an astonishing magnitude, much higher than previously anticipated. Importantly, some of the genes transferred by transduction are virulence and antibiotic resistance genes, highlighting the impact that this process has in driving evolution of pathogenic bacteria.Keywords: E. coli; HGT; MGEs; Bacteriophages; Transduction; virulence Genes
The RunningLine
Health information Technology department
2023-04-14
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1481
Advancements in Life Sciences; Vol 10, No 1 (2023): Advancements in Life Sciences; 17-21
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1481/906
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/659
2018-11-27T02:30:53Z
ALS:RA
3D-Bioprinting: A stepping stone towards enhanced medical approaches
Ashraf, Hajra
Meer, Bisma
Naz, Romasa
Saeed, Aarooj
sadia, Haleema
Sajid, Usmara
Nisar, Kanwal
Aslam, Zuniara
Anwar, Pervez
biotechnology;molecular biology;genomics
In the past few decades, tissue engineering has been seen unprecedented escalation driving the field of artificial tissue and organ construct and brought metamorphosis in regenerative medicine. Prime advancement has been attained through the expansion of novel biomanufacturing approaches to devise and convene cells in three dimensions to fabricate tissue contrive. Accompaniment manufacturing differently known as 3D bioprinting is leading prime innovation in a number of applications in life sciences such as tissue and organ construct, personalized drug dosing, cancer model and heart tissue engineering. Overall, this review summarizes most prevalent bioprinting technologies; including laser-based bioprinting, extrusion bioprinting, injection bioprinting, stereolithography as well as biomaterial such as bioink. It also explores 3D industries, approaches such as Biomimicry, autonomous self-assembly, mini tissues and biomedical applications. Existing challenges that impede clinical mileage of bioprinting are also discussed along with future prospective.Keywords: Bioprinting, tissue engineering, tissue and organ construct, medicinal approach
The RunningLine
2018-08-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/659
Advancements in Life Sciences; Vol 5, No 4 (2018): Advancements in Life Sciences; 143-153
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/659/245
Copyright (c) 2018 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1468
2022-11-05T03:24:51Z
ALS:RA
Recent Advances in the Role of Vitamins in the Prevention and Treatment of Alzheimer’s Disease: A Literature Review
Sohail, Bazza
Nafe, Abdul Wasay
Malik, Robina
Health; Nutrition; Vitamins
Main objective of this review is critically evaluate the use of vitamins in the safety measure as well as treatments of Alzheimer’s disease (AD) using recent findings of research on both humans and animals. The authors combed through the fundamental literature on association of vitamins (fat-soluble vitamins, water-soluble vitamins and some quasi vitamins) with prevention/treatment of AD to create this narrative review. An online search was conducted in Science Direct, Google Scholar, EBSCO & PubMed, a manual search via catalogues and scientific journals for review the literature regarding the relationship between vitamins and AD and to comprehend the potential mechanisms that may clarify such a relationship. After evaluating the titles and abstracts of the preliminary 500 articles, 350 were chosen. After reading the full texts and accomplishing a supplemental search on "Related citations" and the references of the chosen articles, a total of 282 references were found. The two most frequently mentioned ways that vitamins may affect cognitive function in AD are (1) by influences on a particular plasma amino acid called homocysteine (Hcy) for B vitamins (B6, B9 & B12), and (2) through antioxidant effects, decreasing the free radicals’ contents which can impairment human cells, for vitamins B2, C, D, E, as well as ß-carotene. These theories concerning potential mechanisms are mostly based on preclinical research and findings of links between dementia or cognitive decline and elevated Hcy levels or elevated markers of oxidative stress. The results from current studies show an effectiveness and safety of vitamin supplementation to avert mild cognitive impairment (MCI) as well as the initial phases of AD will likely rely on firstly which metabolic pathways are affected, secondly which vitamins are lacking and could correct the pertinent metabolic flaw, and thirdly, the modulating effect of nutrient-nutrient and nutrient-genotype interaction. Further emphasis on an accurate dietary strategy is needed to recognize the complete prospective of vitamin therapy in avoiding dementia and cognitive function as well as to avoid causing devastation.
The RunningLine
Riphah Internatioal University, Islamabad, Pakistan
2022-11-04
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1468
Advancements in Life Sciences; Vol 9, No 3 (2022): Advancements in Life Sciences; 239-269
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1468/771
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/155
2016-11-24T01:23:28Z
ALS:RA
Development of herbicide resistant crops through induced mutations
Rizwan, Muhammad
Akhtar, Sajjad
Plant Breeding, Agronomy, Weed Science
Herbicide resistance is an innate characteristic of crop plants. It enables them to survive and propagate even in the presence of lethal doses of herbicides in the surroundings. Genetic tolerance in crops towards herbicides may have several benefits. It may increases safety margins between weed and crop sensitivity and also expands applicability of a particular herbicide. Besides, it can also lower the operating cost for weed control as compared to manual weeding and crop rotation which is normally prohibited by herbicide persistence. Herbicide resistant crops are developed through transformation of a plant with either native or mutant resistant genes, seed mutagenesis, plant cell or tissue culture and through other traditional plant breeding techniques. Seed mutagenesis is a non-transgenic approach, which is found to be most economical and perfect approach. Moreover, all commercial herbicide tolerant crops were derived from single nucleotide substitution of genes and trait can be incorporated into elite varieties because of incomplete dominance and non-pleiotropic effect of the alleles of all commercial herbicide tolerant mutations.
The RunningLine
2015-11-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/155
Advancements in Life Sciences; Vol 3, No 1 (2015): Advancements in Life Sciences; 01-08
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/155/97
oai:ojs.submission.als-journal.com:article/910
2022-07-05T10:41:28Z
ALS:RA
Prunus Avium L.; Phytochemistry, Nutritional and Pharmacological Review
Hussain, Shabbir
Javed, Mohsin
Abid, Muhammad Amin
Khan, Muhammad Amjad
Syed, Shahzada Khurram
Faizan, Muhammad
Feroz, Farah
Prunus avium L., Sweet cherry; Phytochemistry; Pharmacotheraputics
Current studies were made to investigate the phytochemistry, nutritional and pharmacological studies on Prunus Avium L. (sweet cherry or wild cherry). The plant is a rich source of many phytochemicals, nutrients, phenolic compounds, sugars, anthocyanins, perillyl and phenolics. The presence of chemical compounds such as cyanidin 3-sophoroside, cyanidin 3-rutinoside, cyanidin 3-glucosylrutinoside, cyanidin 3-glucoside etc. renders the cherry fruit to demonstrate anti-cancer and anti-oxidation potential, antigenotoxic, anti-inflammatory, cytotoxic, antimicrobial, neuroprotective and diuretic activities. Cherry consists of cyanogenic glucoside (prunasin) which assists the body in tranquilizing cough and also effective for nervous touchiness and nervous dyspepsia. For secure treatment of cough, pharmaceutical companies isolate prussic acid from the cherry bark as a dynamic component. Wild cherry is also helpful in treatment of arthritis due to the presence of anthocyanins.Keywords: Sweet cherry; Phytochemicals; Nutrients; Antioxidants; Pharmaceutical
The RunningLine
No such agency, personal effort of authors
2021-12-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/910
Advancements in Life Sciences; Vol 8, No 4 (2021): Advancements in Life Sciences; 307-314
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/910/662
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/2254
2024-03-06T16:36:17Z
ALS:RA
Herbal therapy in diabetes mellitus: A review
Gholamine, Babak
Malviya, Jitendra
Rudiansyah, Mohammad
Kadhem Abid, Mohammed
Hussien Alawadi, Ahmed
Adeli, Omid-Ali
Jalalvand, Masumeh
Papi, Sepideh
Diabetes, Herb, Complications, Treatment, medicinal plants, Medicinal Herbs, Pharmaceutical Plant
Insulin therapy is the mainstay of treatment in patients with type 1 diabetes, while diet and lifestyle changes, and if left untreated, insulin therapy are effective in treating type 2 diabetes. Research has shown that the oldest treatment for diabetes was the use of herbs. Thus, various medicinal plants were used to relieve many of the complications of diabetes. This study aimed to assess the effectiveness of various medicinal plants in the treatment of diabetes. The data on medicinal plants and diabetes were collected from related articles published from 2014 to 2021 in reputable databases such as Cochrane, PubMed, Scopus, ScienceDirect, Embase, and SID. Data analysis showed that medicinal plants such as Allium sativum, Cinnamomum verum, Trigonella graecum foenum, Silybum marianus, Citrullus colocynthis, Abelmoschus esculentus, Eryngium, Coriandrum sativum L, and Zingiber officinale were the most frequently used herbs in the treatment of diabetes. Medicinal plants can reduce blood sugar in patients due to having effective medicinal compounds and natural antioxidants and due to the least side effects but longer treatment period.Keywords: Diabetes; Medicinal plants; Remedy; Pharmaceutical Plant
The RunningLine
Diabetes, Herb, Complications, Treatment, medicinal plants, Medicinal Herbs, Pharmaceutical Plant
2024-03-06
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/2254
Advancements in Life Sciences; Vol 11, No 1 (2024): Advancements in Life Sciences; 40-48
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/2254/1410
Copyright (c) 2024 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/62
2014-06-05T02:51:18Z
ALS:RA
Genetically Modified Foods: Engineered tomato with extra advantages
Ali, Arfan
Muzaffar, Adnan
Awan, Mudassar Fareed
Din, Salah ud
Nasir, Idrees Ahmad
Husnain, Tayyab
Molecular Biology; Biotechnology
Currently, genetically modified crops are among the most important constituents in all aspect of our life. Recent controversies about genetically modified crops in United Kingdom and other European countries indicate the apparent differences in public opinion on this subject across the Atlantic, where people do seem untroubled with GMO as compared to other countries. Among plants after potato, tomato is the model plant for genetic changes. A number of genetic modifications of tomato are available especially against different insects, pests and fungus. Gene silencing techniques against viruses have been applied for silencing the expression of damage causing gene. Genetic modifications inducing significant events regarding fruits ripening and growth in tomato and vaccines are of the particular importance. In this review article, we have covered genetic modifications which cause insect, virus and fungus resistance; confer fast growth, chilling and drought tolerance, increased and improved nutrients, yield, fruit ripening, quality and color of the tomato. Factors affecting photosynthesis and metabolic rate are also reviewed in this article.
The RunningLine
2014-05-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://submission.als-journal.com/index.php/ALS/article/view/62
Advancements in Life Sciences; Vol 1, No 3 (2014): Advancements in Life Sciences; 139-152
2310-5380
en
oai:ojs.submission.als-journal.com:article/959
2020-11-27T03:56:41Z
ALS:RA
Hyperhomocysteinemia: The independent risk factor of cardiovascular diseases
Tanweer, Afifa
Bano, Abida
Fatima, Warda
Javed, Hasnain
Hyperhomocysteinemia (Hcy) is an independent risk factor for cardiovascular diseases (CVD) and associated with primary causes of mortality and morbidity throughout the world. Association between Hcy and CVD has been a question for biologists over the last five decades. The circulating levels of Hcy can be increased by defects in enzymes involved in the metabolism of several B and therefore for homocysteine. Although researchers have yielded conflicting findings on the link between homocysteine and CVD risk, but there is convincing evidence on link between B vitamin deficiencies and increased CVD risk. This review identifies the research conducted on this subject matter and provides a framework for the factors associated with Hcy and CVD.Keywords: Hyperhomocysteinemia; CVD; Methionine; Homocysteine
The RunningLine
2020-11-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/959
Advancements in Life Sciences; Vol 8, No 1 (2020): Advancements in Life Sciences; 01-07
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/959/461
Copyright (c) 2020 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1674
2023-11-02T15:34:59Z
ALS:RA
An updated review on anti-diabetic agents and their functions: a comparative study
Hussain, Abrar
Latif, Abdul
Rehmat, Zainia
Riaz, Musarat
Jamil, Nelofer
Amir, Muhammad
Asif, Muhammad
Health and Epidemiological studies
Chronic metabolic disease is considered by a high concentration of glucose in the blood consequent from imperfections in insulin secretion or insulin action. Currently, it is rapidly becoming an epidemic in several nations around the world affecting millions of people. Hence, it is predicted that the number of affected may double in the next couple of years. This increase may be due to the rise in the aging population, adding to an already existing burden on healthcare providers, particularly in developing countries. Based on the unusual elevation of plasma glucose diabetes is divided into two main types, comprising type (1, 2) DM, gestational diabetes mellitus, neonatal diabetes, maturity-onset diabetes of the young (MODY), and squeals induced by endocrinopathies, the consumption of steroids, along with other elements. T1 diabetes mellitus and T2 diabetes mellitus are considered inadequate insulin synthesis. Type 1 diabetes is a condition that usually affects young people, while type 2 diabetes is more common in older individuals who have unhealthy lifestyles. Both types of diabetes have different causes, symptoms, and treatments due to their distinct differences in how the body processes sugar. The aim of the present study is to learn more specifically pertaining to diabetes mellitus, its complications including clinical appearance, associated risk factors, anti-diabetic regime and its consequences at present.
The RunningLine
2023-10-23
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1674
Advancements in Life Sciences; Vol 10, No 3 (2023): Advancements in Life Sciences; 326-334
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1674/1087
Copyright (c) 2023 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/877
2019-11-27T10:05:03Z
ALS:RA
Dry sockets – a systemic review
Almutairi, Bassam Mohammad
Health and Epidemiological studies
This is a systematic review, which shows a compendious review about the aetiology, prevention and treatment of Alveolar Osteitis. After tooth extraction the most common postoperative complication is dry socket. In oral surgery it is very essential to know about the pathophysiology aetiology, prevention and treatment of dry socket. The main purpose of this review article is to provide enough knowledge about the processes that are involved in the clinical management of dry socket. This article shows certain risk factors involved in the incidence of dry socket. surgical trauma, lack of operator experience, mandibular third molars, oral contraceptives, menstrual cycles, smoking, bacterial infections, excessive irrigation, age, bone fragments, local anaesthetics, we will discuss all of these factors which are involved in the incidence of alveolar osteitis in this article. Furthermore, some prevention methods have also been discovered which can be applied to prevent from the incidence of dry socket. Certain treatment methods have also been identified and the have played the vital role in treating the dry socket disease, this article also shows the relation between the Fibrinolysis and the occurrence of dry socket. Various treatment methods, which involve the use of antibiotics, chlorhexidine (as preventive measure also), steroids, anti-fibrinolytics, low-level laser therapy, have been identified which play a vital role in the treatment of dry socket disease.Keywords: Dry Socket; Joints; Anti-fibrinolytics; Review; Chlorhexidine
The RunningLine
2019-11-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/877
Advancements in Life Sciences; Vol 7, No 1 (2019): Advancements in Life Sciences; 48-57
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/877/327
Copyright (c) 2019 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1444
2023-02-19T03:12:16Z
ALS:RA
Deciphering the Potential Therapeutic Intervention Points of 2019-nCoV: A Pharmacological Perspective
Khurshid, Asma
Amin, Rashid
Aziz, Athar
Ahmed, Omema
E. F. Abdel-Haliem, Mahmoud
Microbiology; Immunology; Virology
The emerging and re-emergence of viral outbreaks in the history of mankind has always pose severe global intimidation to public health and economy. The debilitating effects of 2019-nCoV (2019 novel coronavirus) outbreak has swiftly spread worldwide due to its highly contagious nature with severe risk of respiratory tract infections and higher mortality rate, necessitating the urgent need for the production of effective vaccine and potential therapeutic agents. The active evolution of SARS-CoV-2 strain in different population and environment strive immense challenge against anti-viral therapeutic development based on viral pathogenicity. The potential FDA drugs are evaluated based on their known safety and efficacy with exceptional pharmacokinetic profiles for the treatment of nCoV-2019. Existing knowledge related to MERS-CoV and SARS-CoV epidemic has provided a better understanding to explore purposeful therapeutics strategies against novel coronavirus disease (COVID-19). To limited extend, the ongoing promising and hopeful treatments includes convalescent plasma therapy, remdesivir, lopinavir/ritonavir, ACE inhibitors, TMPRSS2 inhibitors, hydroxychloroquine, interferon, ribavirin, tocilizumab, and corticosteroids however clinical efficacy of some of them need to be validated in randomized clinical trials (RCTs). The global struggle to make a protected and successful Coronavirus immunization is finally proving to be fruitful. Although challenges such as strain variation resistant, possible side effects, adequate supply of vaccines to all countries and limited availability of second dose still diverting the option of possible efficacious therapeutics strategies to work alongside with vaccine development with improved efficacy and safety profile. This review is focused on the potential advancement in therapeutic approaches with possible repurposing of the available drugs and explores the current status of available vaccines with hope that these strategies found to be cogent in controlling SARS-CoV-2 outbreak.Keywords: Coronavirus disease 2019 (COVID-19); Remdesivir; Therapeutics; Plasma therapy; Hydroxychloroquine; Anti-viral; Angiotensin-converting enzyme 2; Type II transmembrane serine protease
The RunningLine
N/A
2023-01-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1444
Advancements in Life Sciences; Vol 9, No 4 (2022): Advancements in Life Sciences; 412-428
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1444/875
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/473
2017-11-25T20:04:53Z
ALS:RA
Potential impact of microbial consortia in biomining and bioleaching of commercial metals
Ijaz, Komal
Wattoo, Javed Iqbal
Zeshan, Basit
Majeed, Tanveer
Riaz, Tanzeela
Khalid, Sehar
Baig, Shahjahan
Biomining is the use of microorganisms for the commercial extraction of lavish metals from ores and mines with least effect on environment. Microbes play vital role in bioleaching procedures in commercial mining. The bacterial cells are used to detoxify/replace waste cyanide, marginal biomass and activated carbon. These methods are preferred over conventional techniques due to energy efficient, low cost, environment friendly and production of useful by-products. At industrial scale, different microbial strains (Acidophilic, Sulphobacillus, Rhodococcus, Ferrimicrobium &chemolithotrophic) are deployed to boost the processes of copper and uranium bioleaching. About 20% of the world’s copper is extracted by using this technique. These extraction procedures involve oxidation of insoluble metal sulphides to soluble sulphates. The isolation of thermophilic microbes for mineral biooxidation increase the commercial extraction of minerals at industrial scale. The conventional pyrometallurgical techniques have environmental concerns as they result in depletion of high grade ores and release harmful gaseous. The microbe-assisted gold mining is expected to double the yield of gold and needs to be fully explored using diverse array of microbes. Bioleaching is simple and low cost method for the developing countries with large ore deposits. About 30 strains of microbes have been discovered so for with potential impact on bioleaching. With advances in molecular genetics, physiology and microbial genomics, more promising strains with increased bioactivities are possible. Further efforts are underway to culture diverse range of archaea and improving its genetic potential to be used as industrial tool for commercial bioleaching. The currents review enlightens the recent trends in biomining/bioleaching and implementation of modern biological approaches to engineer target microbes for commercial use.
The RunningLine
2017-11-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/473
Advancements in Life Sciences; Vol 5, No 1 (2017): Advancements in Life Sciences; 13-18
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/473/186
https://submission.als-journal.com/index.php/ALS/article/downloadSuppFile/473/105
Copyright (c) 2017 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1263
2022-08-27T03:36:01Z
ALS:RA
Epidemiology of Obesity in Asia: Challenges and Prevention
Raheem, Asif
Sultan, Rabia
Yasmeen, Humaira
Health and Epidemiological studies, Molecular Biology, Genomics
Obesity is a complex, multifactorial and largely preventable disease affecting over a third of the world’s population today. In this review, prevalence of childhood and adult obesity, its causes, risk factors, interventions and management in different Asian countries was explored. It has been observed that obesity has grown up as an epidemic and it will intensify in the coming years if appropriate preventive measures are not adopted. Proper policies are needed to be implemented. Additionally, massive nation-wide public awareness programs with better structural infrastructure will be answer to this giant problematic challenge.Keywords: Asia, body mass index; Obesity; Physical Activity; Prevalence; World Health Organization
The RunningLine
2022-08-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1263
Advancements in Life Sciences; Vol 9, No 2 (2022): Advancements in Life Sciences; 125-130
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1263/705
Copyright (c) 2022 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/116
2015-02-25T00:00:25Z
ALS:RA
Phytotoxicity of Hg and its Detoxification through Microorganisms in Soil
Amin, Aatif
Latif, Zakia
Environmental Microbiology; Public Health
Due to the advent of industrialization, pollution of terrestrial environment by heavy metals has emerged as a great issue. Therefore, it is an urgent need to realize the Hg-induced toxicity in plants and as well as in animals and the harmful effects by the consumption of contaminated nutrition. Mercury is considered as a hazardous contaminant that can be changed into various oxidation states easily and causes many deleterious effects in several physiological processes in both plants and animals. Microorganisms possess two extensively studied Hg-detoxification processes like Mer operon (merTPCFAD) and Met gene which encode the functional proteins for transportation (merT, merP and/or merC, merF), reduction (merA) and a secondary regulatory protein (merD) and sulfhydrylase enzymes (met gene) respectively to modify toxic Hg+2 to nontoxic elemental state (Hg0). Due to the ever increase in Hg-pollution and very little information about its phytotoxic effects and detoxification mechanisms, the authors expect, the present article will make possibility in the provision of a comprehensive literature study about Hg-induced toxicity in plants and its detoxification processes to provoke for advance research in this field.
The RunningLine
2015-02-25
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/116
Advancements in Life Sciences; Vol 2, No 2 (2015): Advancements in Life Sciences; 98-105
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/116/61
oai:ojs.submission.als-journal.com:article/1094
2021-08-04T19:18:33Z
ALS:RA
Industrial Pesticides and a Methods Assessment for the Reduction of Associated Risks: A Review
Khayatnezhad, Majid
Nasehi, Fatemeh
Regarding the increasing growth of the population and importance of food security, Iranian Ministry of Agriculture has prioritized and encouraged greenhouse farming products. One of the developmental challenges of greenhouse farming is the current extensive use of chemical fertilizers. Importantly, as raw agricultural products are the main ingredients on the table of Iranian families (Iranians generally tend to eat fresh products), the determination of pesticide residues in such products is of utmost importance. The penetration of resistant contaminants into freshwater resources can lead to detrimental effects on humans and the environment. Concerning the importance of environmental protection and the role of chemical pesticides, this study reviews the pesticides used in the agronomic sector and the associated risks of using chemicals to control pests for society, agriculture, freshwater resources, and the environment.Keywords: Environment; Water resources; Agriculture; Health; Biological method
The RunningLine
2021-03-13
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1094
Advancements in Life Sciences; Vol 8, No 2 (2021): Advancements in Life Sciences; 202-210
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1094/530
Copyright (c) 2021 Advancements in Life Sciences
oai:ojs.submission.als-journal.com:article/1858
2024-01-08T07:56:30Z
ALS:RA
A Review of the Effects of Omega-3 and Omega-6 on Alcoholic and Non-Alcoholic Fatty Liver
Darvishi, Mohammad
Majid Alsaraf, Khulood
Alaa Toama, Mariam
K. Hadrawi, Salema
F. Ramadan, Montather
Pirhadi, Mohadeseh
Adeli, Omid-Ali
A Review, Effects, Omega-3, Omega-6, Alcoholic and Non-Alcoholic Fatty Liver
Non-alcoholic fatty liver disease is a type of fatty fat that causes an increase in alcohol consumption. Excessive alcohol consumption causes inflammation, and liver damage. The certain fatty acids (FAs) may be involved in this liver damage. Anti-inflammatory and blood lipid lowering effects are the effects of omega-3 unsaturated fatty acids (n-3 PUFAs). NAFLD is the hepatic manifestation of metabolic syndrome because obesity and insulin resistance are the main pathogenic factors of both diseases. NAFLD is a disease associated with metabolic syndrome. Most patients with NAFLD are obese, although the disease can also affect non-obese people. Metabolic and genetic factors play an important role in the occurrence of this disease. Oxidative stress, lipotoxicity and inflammation play a key role in the development of NAFLD. There is a lot of evidence for the therapeutic potential of omega-3 PUFAs fatty acids (n-3 PUFA), mainly docosahexaenoic acid and eicosatetraenoic acid in the treatment of metabolic diseases due to their antioxidant and anti-inflammatory properties. Therefore, in this review article, we examined the effects of omega-3 and omega-6 on alcoholic and non-alcoholic fatty liver disease.
The RunningLine
A Review, Effects, Omega-3, Omega-6, Alcoholic and Non-Alcoholic Fatty Liver
2024-01-08
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
application/pdf
https://submission.als-journal.com/index.php/ALS/article/view/1858
Advancements in Life Sciences; Vol 10, No 4 (2023): Advancements in Life Sciences; 530-536
2310-5380
eng
https://submission.als-journal.com/index.php/ALS/article/view/1858/1283
Copyright (c) 2023 Advancements in Life Sciences