Interleukin 10 (IL-10) promoter-1082 A>G polymorphism and risk of cancer: Meta-analysis

Muhammad Tahir Khan, Sahar Afzal, Ashfaq Ur Rehman, Tariq Zeb


Background: Interleukin-10-1082A>G variant is the most widely investigated polymorphism in the IL-10 gene in cancer susceptibility. A number of case control analysis showed the link between IL-10-1082A >G polymorphism and cancer risk in humans population.

Methods: Twenty three case–control eligible studies, comprising 4753 cases and 6086 controls were selected for the meta-analysis of IL-10-1082 A/G SNP. The statistical analysis was conducted with comprehensive meta-analysis (CMA). We adopted heterozygous (GG vs. AG) model. Odds ratio (OR) with 95% confidence interval (CIs) was calculated to measure the power of the link under heterozygous model (GG vs AG).

Result: Overall result obtained under fixed effect model are [OR: 1.066, 95% CI: 0.989-1.267, P: 0.464].

Conclusion: Our meta-analysis indicates that IL-10 promoter-1082 polymorphism under fixed effect model is not associated with the overall risk of developing cancer, HCV, Bechet’s disease and diabetes type-2.

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