Interleukin 10 (IL-10) promoter-1082 A>G polymorphism and risk of cancer: Meta-analysis

Muhammad Tahir Khan, Sahar Afzal, Ashfaq Ur Rehman, Tariq Zeb

Abstract


Background: Interleukin-10-1082A>G variant is the most widely investigated polymorphism in the IL-10 gene in cancer susceptibility. A number of case control analysis showed the link between IL-10-1082A >G polymorphism and cancer risk in humans population.

Methods: Twenty three case–control eligible studies, comprising 4753 cases and 6086 controls were selected for the meta-analysis of IL-10-1082 A/G SNP. The statistical analysis was conducted with comprehensive meta-analysis (CMA). We adopted heterozygous (GG vs. AG) model. Odds ratio (OR) with 95% confidence interval (CIs) was calculated to measure the power of the link under heterozygous model (GG vs AG).

Result: Overall result obtained under fixed effect model are [OR: 1.066, 95% CI: 0.989-1.267, P: 0.464].

Conclusion: Our meta-analysis indicates that IL-10 promoter-1082 polymorphism under fixed effect model is not associated with the overall risk of developing cancer, HCV, Bechet’s disease and diabetes type-2.


Full Text:

PDF

References


Kingo K, Rätsep R, Kõks S, Karelson M, Silm H, et al. Influence of genetic polymorphisms on interleukin-10 mRNA expression and psoriasis susceptibility. Journal of Dermatological Science, (2005); 37(2): 111-113.

Huang S, Ullrich SE, Bar-Eli M. Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience. Journal of interferon & cytokine research, (1999); 19(7): 697-703.

Matsumoto K, Oki A, Satoh T, Okada S, Minaguchi T, et al. Interleukin-10− 1082 gene polymorphism and susceptibility to cervical cancer among Japanese women. Japanese Journal of Clinical Oncology, (2010); 40(11): 1113-1116.

Bai H, Jing D, Guo A, Yin S. Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population. Journal of International Medical Research, (2014); 42(3): 702-710.

Çil E, Kumral A, Kanmaz-Özer M, Vural P, Doğru-Abbasoğlu S, et al. Interleukin-10-1082 gene polymorphism is associated with papillary thyroid cancer. Molecular Biology Reports, (2014); 41(5): 3091-3097.

Talaat RM, Ashour ME, Bassyouni IH, Raouf AA. Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet's disease. Immunobiology, (2014): 219(8); 573-582.

Zhou J, Zhang D, Chen B, Li Q, Zhou L, et al. Association of interleukin-10 promoter polymorphisms and corresponding plasma levels with susceptibility to laryngeal squamous cell carcinoma. Oncology Letters, (2014); 7(5): 1721.

Lech‐Maranda E, Mlynarski W, Grzybowska‐Izydorczyk O, Borowiec M, Pastorczak A, et al. Polymorphisms of TNF and IL‐10 genes and clinical outcome of patients with chronic lymphocytic leukemia. Genes, Chromosomes and Cancer, (2013); 52(3): 287-296.

Bhayal AC, Krishnaveni D, Rao KPR, Prabhakar B, Vidyasagar A, et al. Association of Interleukin-10 Promoter Polymorphism (-1082 G/A) and Gastric Cancer in Andhra Pradesh Population of South India. Iranian Journal of Cancer Prevention, (2012); 5(3): 117-123.

Zhou Y, Hu W, Zhuang W, Wu X. Interleukin-10− 1082 promoter polymorphism and gastric cancer risk in a Chinese Han population. Molecular and Cellular Biochemistry, (2011); 347(1-2): 89-93.

Shin CM, Kim N, Lee HS, Lee DH, Kim JS, et al. Intrafamilial aggregation of gastric cancer: a comprehensive approach including environmental factors, Helicobacter pylori virulence, and genetic susceptibility. European Journal of Gastroenterology & Hepatology, (2011); 23(5): 411-417.

Liu J, Song B, Wang J-L, Li Z-J, Li W-H, et al. Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer. World Journal of Gastroenterology, (2011); 17(10): 1362.

Liu J, Song B, Bai X, Liu W, Li Z, et al. Association of genetic polymorphisms in the interleukin-10 promoter with risk of prostate cancer in Chinese. BMC Cancer, (2010); 10(1): 456.

Afzal MS, Tahir S, Salman A, Baig TA, Shafi T, et al. Analysis of interleukin-10 gene polymorphisms and hepatitis C susceptibility in Pakistan. The Journal of Infection in Developing Countries, (2011); 5(06): 473-479.

Kong F, Liu J, Liu Y, Song B, Wang H, et al. Association of interleukin-10 gene polymorphisms with breast cancer in a Chinese population, (2010); 29: 72.

Bouzgarrou N, Hassen E, Farhat K, Bahri O, Gabbouj S, et al. Combined analysis of interferon-γ and interleukin-10 gene polymorphisms and chronic hepatitis C severity. Human Immunology, (2009); 70(4): 230-236.

Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, et al. Effects of interleukin‐10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects. Journal of Gastroenterology and Hepatology, (2007); 22(9): 1443-1449.

Xiao H, Jiang Y, Li R, Xia B. Association of IL-10 gene polymorphisms with gastroduodenal diseases in Hubei Han population. Chinese Journal of Medical Genetics, (2009); 26(4): 423-426.

Kang JM, Kim N, Lee DH, Park JH, Lee MK, et al. The effects of genetic polymorphisms of IL-6, IL-8, and IL-10 on Helicobacter pylori-induced gastroduodenal diseases in Korea. Journal of Clinical Gastroenterology, (2009); 43(5): 420-428.

Yao J-G, Gao L-B, Liu Y-G, Li J, Pang G-F. Genetic variation in interleukin-10 gene and risk of oral cancer. Clinica Chimica Acta, (2008); 388(1): 84-88.

Crusius J, Canzian F, Capellá G, Pena A, Pera G, et al. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Annals of Oncology, (2008); mdn400.

Lee JY, Kim HY, Kim KH, Kim SM, Jang MK, et al. Association of polymorphism of IL-10 and TNF-A genes with gastric cancer in Korea. Cancer Letters, (2005); 225(2): 207-214.

Nieters A, Yuan JM, Sun CL, Zhang ZQ, Stoehlmacher J, et al. Effect of cytokine genotypes on the hepatitis B virus‐hepatocellular carcinoma association. Cancer, (2005); 103(4): 740-748.

Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, et al. Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. The Journal of Immunology, (2001); 166(6): 3915-3922.

Bodger K, Bromelow K, Wyatt J, Heatley R. Interleukin 10 in Helicobacter pylori associated gastritis: immunohistochemical localisation and in vitro effects on cytokine secretion. Journal of Clinical Pathology, (2001); 54(4): 285-292.

Cui Y, Xue H, Lin B, Ni P, Fang J-Y. A meta-analysis of CDH1 C-160A genetic polymorphism and gastric cancer risk. DNA and Cell biology, (2011); 30(11): 937-945.

Lu W, Pan K, Zhang L, Lin D, Miao X, et al. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor α and risk of gastric cancer in a Chinese population. Carcinogenesis, (2005); 26(3): 631-636.


Refbacks

  • There are currently no refbacks.