RETRACTED ARTICLE: Association between polymorphism of the CRP gene rs1130864 and hypertension among Iraqi hypertensive patients
Abstract
Background: C-reactive protein (CRP) a reactant of the acute phase and a measure of persistent low-grade inflammatory processes. Objectives of this paper to the role of rs1130864 polymorphism in CRP gene among Iraqi hypertensive patients.
Methods: Samples of blood were collected from patients with hypertension and controls, their age (37 to 75). Hardy-Weinberg equilibrium (HWE) was used to calculate the risk score for the disease of hypertension, Moreover, PCR/SNP (specific primers) was used to do genotyping.
Results: HWE analysis of hypertensive patients and controls showed that the rs1130864 genotypes were in agreement with the equilibrium, without differences clear between the observed and expected genotype frequencies (p >0.153, 0.238). The frequencies of genotype and alleles were compared in hypertensive patients with controls, with no significant differences. The common GG genotype of rs1130864 recorded a significant increase in hypertensive patients and controls and was regarded as a preventative fraction (RR = 0.76), whilst, GA , AA genotype were considered the etiological fraction (RR = 1.06, 2.59) and associated with hypertension. Compared to A allele, which might be the cause of the disease, G allele might be preventive.
Conclusion: The findings showed that the Iraqi population's GA, AA genotype, and A allele are risk factors for hypertension. However, the need for additional findings utilizing bigger samples is needed are necessary to verify our findings.
Keywords: Hypertension; C-reactive protein; Polymorphism, 1444G>A; rs1130864
Retraction Note
24 Sept 2025: The Editor-in-Chief has retracted this article due to the below mentioned scientific deficiencies revealed by an internal audit.
1. The central finding claimed in the abstract, results, and discussion is that the GA and AA genotypes are significantly associated with hypertension. However, the paper's own statistical results in Table 5 show p-values ranging from 0.404 to 1.000, all of which are clearly not significant. The paper's conclusion is demonstrably false based on its own evidence.
2. The authors have systematically misinterpreted non-significant p-values as significant. This is a major error that invalidates the entire analysis and all claims derived from it. The scientific findings are, therefore, unreliable.
3. The authors report Relative Risk (RR) for a case-control study, a methodological error, as the Odds Ratio (OR) is the correct measure of association for this study design.
The authors do not agree to this retraction.
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DOI: http://dx.doi.org/10.62940/als.v10i2.1770
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