Estimate the relationship between SNP of the IL-17 gene (rs2275913) and cardiovascular diseases (CVDs)

Anees Abdul Hassan Thamer Al-Himami, Ali Naeem Salman

Abstract


Background: One cytokine that may be important in cardiovascular diseases (CVD) is interleukin-17 (IL-17). The functions of IL-17 and its receptor genes can be affected by functional genetic variations.

Methods: The study examined the relationship between the IL-17A gene's rs2275913 single-nucleotide polymorphism (SNPs) and cardiovascular diseases (CVD) in 40 samples (30 patients and 10 controls).

Results: The rs2275913 variant had a homozygous GG, heterozygous GA, and homozygous AA pattern in the population under investigation. Most patients were in the homozygous GG state, and the homozygous variant AA was present among patients and controls. The IL-17A gene had patterns of polymorphism within the tested Thi-Qar community members.

Conclusion: This study found a genotype-specific association between IL-17A gene rs2275913 variants and cardiovascular disease. The GA heterozygous genotype was significantly higher in healthy volunteers than in patients (p = 0.02), indicating a possible protective effect. While no significant correlation was observed for overall allele frequency, these findings suggest that certain genotypes of this polymorphism may influence CVD prevalence among Thi-Qar residents.

Keywords: IL-17 gene, SNP, Cardiovascular Diseases, rs2275913


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References


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DOI: http://dx.doi.org/10.62940/als.v12i3.2587

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