Association of sleep quality with body fat mass and metabolic factors in Iranian adults in 2020

Mazyar Haghgoo, Hakimeh Saadeghzadeh, Atoosa Saidpour, Samira Rabiei


Background: Poor sleep quality is increasingly recognized as a risk factor for poor health outcomes such as obesity, diabetes and cardiovascular diseases. This study aimed to investigate the association between sleep quality, obesity and glycemic and lipid profiles in Iranian adults in 2020.

Methods: 353 adults aged 18-60 years from community centers in Tehran municipality took apart in this cross-sectional study by convenience sampling. Information on anthropometric measurements, physical activity and dietary intake were collected. Sleep quality was assessed through Pittsburgh Sleep Quality Index. Body composition was measured through BIA method. Auto analyzer was used to measure fasting blood sugar (FBS)and lipid profile and ELISA method was used to measure Insulin.

Results: The mean age was 42.92±11.34 and 39.16±14.18 for women and men, respectively. Each one score increase in total sleep quality, was related to 0.1 cm increase in waist circumference and 0.3 % increase in body fat percent (P <0.05). BMI had a positive correlation with subscales of “sleep disturbances” and “use of sleep medication” (P <0.001)Physical activity had a significant negative correlation with subscales of “subjective sleep quality” and “sleep latency”. FBS and triglyceride had positive correlation with “sleep latency” and “Subjective sleep quality”, respectively (P <0.05).

Conclusion: Some determinants of sleep quality are associated with obesity, disorders of glucose and triglyceride metabolism and low level of physical activity.

Keywords: Sleep quality; PSQI questionnaire; Body fat mass; Fasting Blood Sugar; Lipid profile

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Hung H-C, Yang Y-C, Ou H-Y, Wu J-S, Lu F-H, et al. The association between self-reported sleep quality and overweight in a Chinese population. Obesity (Silver Spring, Md), (2013); 21(3): 486-492.

Paine S, Gander P, Travier N. The epidemiology of morningness/eveningness: influence of age, gender, ethnicity, and socioeconomic factors in adults (30-49 years). Journal of biological rhythms, (2006); 21(1): 68-76.

Iyegha ID, Chieh AY, Bryant BM, Li L. Associations between poor sleep and glucose intolerance in prediabetes. Psychoneuroendocrinology, (2019); 110104444.

Mokarrar M, Afsharmanesh A, Afshari M, Mohammadi F. Prevalence of Sleep Disorder among Medical Students in an Eastern University in Iran. Iranian Journal Of Health Sciences, (2017); 5(1): 49-54.

Heidari Mokarrar M, Afsharmanesh A, Afshari M, Mohammadi F. Prevalence of sleep disorder among medical students in an Eastern university in Iran. Iranian Journal of Health Sciences, (2017); 5(1): 49-54.

Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, et al. Sleep duration as a risk factor for diabetes incidence in a large U.S. sample. Sleep, (2007); 30(12): 1667-1673.

Makino S, Hirose S, Kakutani M, Fujiwara M, Nishiyama M, et al. Association between nighttime sleep duration, midday naps, and glycemic levels in Japanese patients with type 2 diabetes. Sleep Medicine, (2018); 444-11.

Byrne EM, Gehrman PR, Trzaskowski M, Tiemeier H, Pack AI. Genetic Correlation Analysis Suggests Association between Increased Self-Reported Sleep Duration in Adults and Schizophrenia and Type 2 Diabetes. Sleep, (2016); 39(10): 1853-1857.

Bjorvatn B, Sagen IM, Øyane N, Waage S, Fetveit A, et al. The association between sleep duration, body mass index and metabolic measures in the Hordaland Health Study. Journal of Sleep Research, (2007); 16(1): 66-76.

Gangwisch JE, Malaspina D, Babiss LA, Opler MG, Posner K, et al. Short sleep duration as a risk factor for hypercholesterolemia: analyses of the National Longitudinal Study of Adolescent Health. Sleep, (2010); 33(7): 956-961.

Kaneita Y, Uchiyama M, Yoshiike N, Ohida T. Associations of usual sleep duration with serum lipid and lipoprotein levels. Sleep, (2008); 31(5): 645-652.

Kinuhata S, Hayashi T, Sato KK, Uehara S, Oue K, et al. Sleep duration and the risk of future lipid profile abnormalities in middle-aged men: the Kansai Healthcare Study. Sleep Medicine, (2014); 15(11): 1379-1385.

Kong AP, Wing YK, Choi KC, Li AM, Ko GT, et al. Associations of sleep duration with obesity and serum lipid profile in children and adolescents. Sleep Medicine, (2011); 12(7): 659-665.

Lin PMD, Chang K-T, Lin Y-A, Tzeng IS, Chuang H-H, et al. Association between self-reported sleep duration and serum lipid profile in a middle-aged and elderly population in Taiwan: a community-based, cross-sectional study. BMJ open, (2017); 7(10): e015964-e015964.

Petrov MER, Kim Y, Lauderdale D, Lewis CE, Reis JP, et al. Longitudinal associations between objective sleep and lipids: the CARDIA study. Sleep, (2013); 36(11): 1587-1595.

Sabanayagam C, Shankar A. Sleep duration and hypercholesterolaemia: Results from the National Health Interview Survey 2008. Sleep medicine, (2012); 13(2): 145-150.

Shin HY, Kang G, Kim SW, Kim JM, Yoon JS, et al. Associations between sleep duration and abnormal serum lipid levels: data from the Korean National Health and Nutrition Examination Survey (KNHANES). Sleep Medicine, (2016); 24119-123.

Zhan Y, Chen R, Yu J. Sleep duration and abnormal serum lipids: the China Health and Nutrition Survey. Sleep Medicine, (2014); 15(7): 833-839.

Smiley A, King D, Harezlak J, Dinh P, Bidulescu A. The association between sleep duration and lipid profiles: the NHANES 2013–2014. Journal of Diabetes & Metabolic Disorders, (2019); 18(2): 315-322.

Mullington JM, Chan JL, Van Dongen HP, Szuba MP, Samaras J, et al. Sleep loss reduces diurnal r

hythm amplitude of leptin in healthy men. Journal of Neuroendocrinology, (2003); 15(9): 851-854.

Spiegel K, Leproult R, Tasali E, Penev P, Van Cauter E. Sleep curtailment results in decreased leptin levels and increased hunger and appetite. Sleep, (2003); 26A174.

Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS medicine, (2004); 1(3): e62-e62.

Lampman RM, Schteingart DE. Effects of exercise training on glucose control, lipid metabolism, and insulin sensitivity in hypertriglyceridemia and non-insulin dependent diabetes mellitus. Medicine & Science in Sports & Exercise, (1991); 23(6): 703-712.

Harris ML, Oldmeadow C, Hure A, Luu J, Loxton D, et al. Stress increases the risk of type 2 diabetes onset in women: A 12-year longitudinal study using causal modelling. PloS one, (2017); 12(2): e0172126-e0172126.

Goodin B, Smith M, Quinn N, King C, McGuire L. Poor sleep quality and exaggerated salivary cortisol reactivity to the cold pressor task predict greater acute pain severity in a non-clinical sample Biological psychology, (2012); 91(1): 36-41.

Rusch H, Guardado P, Baxter T, Mysliwiec V, Gill J. Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, (2015); 11(6): 615-623.

Patel P, Abate N. Body fat distribution and insulin resistance. Nutrients, (2013); 5(6): 2019-2027.

Potter G, Skene D, Arendt J, Cade J, Grant P, et al. Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures. Endocrine Reviews, (2016); 37(6): 584-608.

Banks S, Dinges D. Behavioral and physiological consequences of sleep restriction. Journal of

clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, (2007); 3(5): 519-528.

Simpson N, Banks S, Arroyo S, Dinges D. Effects of sleep restriction on adiponectin levels in healthy men and women. Physiology & Behavior, (2010); 101(5): 693-698.

Buysse D, Reynolds C, Monk T, Berman S, Kupfer D. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Researcg, (1989); 28(2): 193-213.

Moghaddam M, Bakhtari Aghdam F, Asghari Jafarabadi M, Allahverdipour H, Dabagh Nikookheslat S, et al. The Iranian Version of International Physical Activity Questionnaire (IPAQ) in Iran: Content and Construct Validity, Factor Structure, Internal Consistency and Stability, (2012); 1073-1080.

Jennings J, Muldoon M, Hall M, Buysse D, Manuck S. Self-reported sleep quality is associated with the metabolic syndrome. Sleep, (2007); 30(2): 219-223.

Narang I, Manlhiot C, Davies-Shaw J, Gibson D, Chahal N, et al. Sleep disturbance and cardiovascular risk in adolescents. CMAJ, (2012); 184(17): E913-920.

Cipolla-Neto J, Amaral F, Afeche S, Tan D, Reiter R. Melatonin, energy metabolism, and obesity: a review. J Pineal Res, (2014); 56(4): 371-381.

Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Medicine Reviews, (2005); 9(1): 11-24.

Yang P, Ho K, Chen H, Chien M. Exercise training improves sleep quality in middleaged and older adults with sleep problems: a systematic review. J Physiother, (2012); 58157–163.

Tworoger S, Yasui Y, Vitiello M. Effects of a yearlong moderate-intensity exercise and a stretching intervention on sleep quality in postmenopausal women. Sleep, (2003); 26830–836.

Khorasani M, Mohammadpoorasl A. The association between sleep quality and metabolic factors and anthropometric measurements. Biotechnology and Health Sciences, (2016); 3(4): 25-31.

Zhu B-Q, Li X-M, Wang D, Yu X-F. Sleep quality and its impact on glycaemic control in patients with type 2 diabetes mellitus. International Journal of Nursing Sciences, (2014); 1(3): 260-265.

Minokoshi Y, Toda C, Okamoto S. Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle. Indian Journal of Endocrinology and Metabolism, (2012); 16(Suppl 3): S562-568.

Harris R. Direct and Indirect Effects of Leptin on Adipocyte Metabolism. Biochimica et biophysica

acta, (2013); 1842.

Tahrani AA. Obstructive sleep apnoea in diabetes: Does it matter? Diabetes and Vascular Disease Research, (2017); 14(5): 454–462.

Said S, Mukherjee D, Whayne TF. Interrelationships with metabolic syndrome, obesity and cardiovascular risk. Current Vascular Pharmacology, (2016); 14(5): 415–425.

Beccuti G, Pannain S. Sleep and obesity. Current opinion in clinical nutrition and metabolic care, (2011); 14(4): 402-412.

Dempsey JA, Veasey SC, Morgan BJ, O'Donnell CP. Pathophysiology of sleep apnea. Physiological reviews, (2010); 90(1): 47-112.

Muscogiuri G, Barrea L, Annunziata G, Di Somma C, Laudisio D, et al. Obesity and sleep disturbance: the chicken or the egg? Critical Reviews in Food Science and Nutrition, (2019); 59(13): 2158-2165.

Hargens TA, Kaleth ES, Edwards, Butner KL. Association between sleep disorders, obesity, and exercise: A review. Nature and Science of Sleep, (2013); 527–35.

Del Brutto OH, Mera RM, Ha JE, Gillman J, Zambrano M, et al. Dietary fish intake and sleep quality: a population-based study. Sleep Medicine, (2016); 17126-128.

Katagiri R, Asakura K, Kobayashi S, Suga H, Sasaki S. Low intake of vegetables, high intake of confectionary, and unhealthy eating habits are associated with poor sleep quality among middle-aged female Japanese workers. Journal of Occupational Health, (2014); 56(5): 359-368.

Kong F, Li H, Xu G, Ying Y, Gong Q, et al. Association of Dietary Behaviors and Sleep Quality: Results from the Adults Chronic Diseases and Risk Factors Survey of 2015 in Ningbo, China. International Journal of Environmental Research and Public Health, (2018); 15(9).

Grandner MA, Kripke DF, Naidoo N, Langer RD. Relationships among dietary nutrients and subjective sleep, objective sleep, and napping in women. Sleep medicine, (2010); 11(2): 180-184.

Brondel L, Romer MA, Nougues PM, Touyarou P, Davenne D. Acute partial sleep deprivation increases food intake in healthy men. American Journal of Clinical Nutrition, (2010); 91(6): 1550-1559.

St-Onge MP. Sleep-obesity relation: underlying mechanisms and consequences for treatment. Obesity Reviews, (2017); 18 Suppl 134-39.


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