Frequency of Hepatocellular Carcinoma in Patients Infected with Hepatitis C Virus visiting a Tertiary Care Hospital in Lahore for Computed Tomographic Evaluation

Nozaina Irum, Muhammad Zakir, Imran Yousaf, Muhammad Yousaf Farooq, Amna Akhtar, Sidra Mehmood, Saleha Tariq, Fakher Un Nisa Bhatti, Rija Zaigham, Zareen Fatima


Background: Hepatitis C virus has been identified as one of the leading causes of chronic liver disease and its complications world-wide. Subsequent development of hepatocellular carcinoma in these patients is a major complication of this infection having serious implications on morbidity and mortality rates. The objective of this study was to find out the frequency of Hepatocellular carcinoma in patients suffering from Hepatitis C visiting Radiology department of a tertiary care hospital for multi-detector computed tomography evaluation.

Methods: This cross-sectional analytical study was conducted at Shalamar Hospital Lahore. A total of 195 patients, suffering from Hepatitis C, visiting Shalamar Hospital, Lahore for evaluation by CT during 6 months study interval were included in this study. Abdominal CT was performed using Triphasic contrast enhancement protocol. All images were interpreted by a senior Radiologist. Frequency of Hepatocellular carcinoma was calculated. Statistical analysis was made using MEDCALC.

Results: Out of 195, 63(32.3%) patients were seen to have hepatocellular carcinoma. This disease was more common in male, 45(34.6%) as compared to female patients 18 (27.7%). The presence of HCC showed statistically significant association with alcoholism, obesity, diabetes mellitus and cirrhosis.

Conclusion: The study concluded that a substantial number of HCV positive patients develop HCC, which is more common in men as compared to women. The presence of HCC is strongly associated with alcoholism, obesity, diabetes mellitus and cirrhosis.

Keywords: Hepatocellular carcinoma (HCC); Hepatitis C (HCV); Multi-detector Computed Tomography (MDCT) 

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