Role of Selective Cyclooxygenase-2 Inhibitors in Renal Colic Pain Reduction and Improvement: A Systematic Review of Clinical Trials
Abstract
Renal colic is an irritating condition that develops after obstruction of the ureter. Selective cyclooxygenase-2 inhibitors are types of non-steroidal anti-inflammatory drugs (NSAIDs) that have beneficial role in treatment various diseases. Hence, this systematic review summarizes the current knowledge about the role of selective cyclooxygenase-2 (COX-2) inhibitors as painkiller in renal colic pain management. The present systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. Until September 2022, PubMed/Medline, Scopus, Web of Science, and Google Scholar databases were searched using the relevant keywords including “Selective Cyclooxygenase-2 Inhibitors”, “Parecoxib”, “Celecoxib”, “Rofecoxib”, “Renal Colic Pain” and “Ureteral Colic Pain”. Of 64 identified records through database searching, 6 randomized controlled trials (RCTs) were selected for this systematic review. The sample size in RCTs were between 53 and 338. The range of subject’s age was from 18 to 69. Overall, the evidence of this review revealed that the selective COX-2 inhibitors particularly celecoxib and parecoxib could alleviate renal colic pain in most of the studies through decreasing relevant pain score. Overall, selective COX-2 inhibitors seem to be effective in alleviating renal colic pain. However, further high quality assessments are required for demonstrating therapeutic role of selective COX-2 inhibitors against renal colic pain.
Keywords: Anti-Inflammatory Agents; Non-Steroidal; Renal Colic; Pain Management
Full Text:
PDFReferences
Bultitude M, Rees J. Management of renal colic. Bmj, (2012); 345e5499.
Raja AS, Pourjabbar S, Ip IK, Baugh CW, Sodickson AD, et al. Impact of a health information technology–enabled appropriate use criterion on utilization of emergency department CT for renal colic. American Journal of Roentgenology, (2019); 212(1): 142-145.
Torabi M, Shojaee F, Mirzaee M. Prevalence of Renal Colic in the Emergency Departments: A Multi-center Study. Hospital Practices and Research, (2021); 6(3): 123-126.
Minotti B, Treglia G, Pascale M, Ceruti S, Cantini L, et al. Prevalence of microhematuria in renal colic and urolithiasis: a systematic review and meta-analysis. BMC urology, (2020); 20(1): 1-12.
Tasian GE, Ross ME, Song L, Sas DJ, Keren R, et al. Annual incidence of nephrolithiasis among children and adults in South Carolina from 1997 to 2012. Clinical journal of the American Society of Nephrology, (2016); 11(3): 488-496.
Scales Jr CD, Smith AC, Hanley JM, Saigal CS, Project UDiA. Prevalence of kidney stones in the United States. European urology, (2012); 62(1): 160-165.
Brown J. Diagnostic and treatment patterns for renal colic in US emergency departments. International urology and nephrology, (2006); 38(1): 87-92.
Azhar M, Kalwar MT, Akhtar N, Altaf A. Prevalence of acute renal colic presenting in emergency department of a tertiary care hospital. Rawal Medical Journal, (2022); 47(1): 152-152.
Steinberg PL, Nangia AK, Curtis K. A standardized pain management protocol improves timeliness of analgesia among emergency department patients with renal colic. Quality Management in Healthcare, (2011); 20(1): 30-36.
Thia I, Saluja M. An update on management of renal colic. Australian Journal of General Practice, (2021); 50(7): 445-449.
Golzari SE, Soleimanpour H, Rahmani F, Mehr NZ, Safari S, et al. Therapeutic approaches for renal colic in the emergency department: a review article. Anesthesiology and pain medicine, (2014); 4(1).
Holdgate A, Oh CM. Is there a role for antimuscarinics in renal colic? A randomized controlled trial. The Journal of urology, (2005); 174(2): 572-575.
Mahamat MA, Diarra A, Kassogué A, Eyongeta D, Valentin V, et al. Renal colic: epidemiological, clinical etiological and therapeutic aspects at the urology department of the national reference general hospital of n’djamena (Chad). Open Journal of Urology, (2020); 10(02): 25.
Kominsky HD, Rose J, Lehman A, Palettas M, Posid T, et al. Trends in acute pain management for renal colic in the emergency department at a tertiary care academic medical center. Journal of endourology, (2020); 34(11): 1195-1202.
Dalziel PJ, Noble VE. Bedside ultrasound and the assessment of renal colic: a review. Emergency Medicine Journal, (2013); 30(1): 3-8.
Payandemehr P, Jalili M, Mostafazadeh Davani B, Dehpour AR. Sublingual buprenorphine for acute renal colic pain management: a double-blind, randomized controlled trial. International journal of emergency medicine, (2014); 7(1): 1-5.
Regulski M, Regulska K, Prukała W, Piotrowska H, Stanisz B, et al. COX-2 inhibitors: a novel strategy in the management of breast cancer. Drug discovery today, (2016); 21(4): 598-615.
Gorabi AM, Abbasifard M, Imani D, Aslani S, Razi B, et al. Effect of curcumin on C‐reactive protein as a biomarker of systemic inflammation: An updated meta‐analysis of randomized controlled trials. Phytotherapy Research, (2022); 36(1): 85-97.
Fu W, Yao J, Li Q, Wang Y, Wu X, et al. Efficacy and safety of parecoxib/phloroglucinol combination therapy versus parecoxib monotherapy for acute renal colic: a randomized, double-blind clinical trial. Cell biochemistry and biophysics, (2014); 69(1): 157-161.
Lv JL, Tang QL. Comparative evaluation of efficacy of use of naftopidil and/or celecoxib for medical treatment of distal ureteral stones. Urolithiasis, (2014); 42(6): 541-547.
Phillips E, Hinck B, Pedro R, Makhlouf A, Kriedberg C, et al. Celecoxib in the management of acute renal colic: a randomized controlled clinical trial. Urology, (2009); 74(5): 994-999.
Engeler DS, Ackermann DK, Osterwalder JJ, Keel A, Schmid H-P. A double-blind, placebo controlled comparison of the morphine sparing effect of oral rofecoxib and diclofenac for acute renal colic. The Journal of urology, (2005); 174(3): 933-936.
Glina S, Damiao R, Afif-Abdo J, Maria CFS, Novoa R, et al. Efficacy and safety of parecoxib in the treatment of acute renal colic: a randomized clinical trial. International braz j urol, (2011);
-705.
Al-Terki A, Hussain J, El-Nahas AR, Aloumi A, Al-Asfoor M, et al. Parecoxib Vs Paracetamol for Treatment of Acute Renal Colic Due to Ureteric Calculi: A Randomized Controlled Trial. Urology, (2021); 14976-80.
Jalili M, Entezari P, Doosti-Irani A, Masoomi R, Mirfazaelian H. Desmopressin effectiveness in renal colic pain management: Systematic review and meta-analysis. The American Journal of Emergency Medicine, (2016); 34(8): 1535-1541.
Holdgate A, Pollock T. Systematic review of the relative efficacy of non-steroidal anti-inflammatory drugs and opioids in the treatment of acute renal colic. Bmj, (2004); 328(7453): 1401.
Davenport K, Timoney AG, Keeley FX. Conventional and alternative methods for providing analgesia in renal colic. BJU international, (2005); 95(3): 297-300.
Serinken M, Karcioglu O, Turkcuer I, Ozkan HI, Keysan MK, et al. Analysis of clinical and demographic characteristics of patients presenting with renal colic in the emergency department. BMC research notes, (2008); 1(1): 1-6.
Nakada SY, Jerde TJ, Jacobson LM, Saban R, Bjorling DE, et al. Cyclooxygenase-2 expression is up-regulated in obstructed human ureter. The Journal of urology, (2002); 168(3): 1226-1229.
Holdgate A, Pollock T. Nonsteroidal anti‐inflammatory drugs (NSAIDs) versus opioids for acute renal colic. Cochrane Database of Systematic Reviews, (2004); (1).
Sander WJ, O'Neill HG, Pohl CH. Prostaglandin E2 as a modulator of viral infections. Frontiers in Physiology, (2017); 889.
Zhu X-T, Chen L, Lin J-H. Selective COX-2 inhibitor versus non-selective COX-2 inhibitor for the prevention of heterotopic ossification after total hip arthroplasty: A meta-analysis. Medicine, (2018); 97(31).
Forouzanfar MM, Mohammadi K, Hashemi B, Safari S. Comparison of intravenous ibuprofen with intravenous ketorolac in renal colic pain management; a clinical trial. Anesthesiology and pain medicine, (2019); 9(1).
Jalili M, Shirani F, Entezari P, Hedayatshodeh M, Baigi V, et al. Desmopressin/indomethacin combination efficacy and safety in renal colic pain management: a randomized placebo controlled trial. The American Journal of Emergency Medicine, (2019); 37(6): 1009-1012.
Faramarzi M, Roosta S, Eghbal MH, Nouri Rahmatabadi B, Faramarzi A, et al. Comparison of celecoxib and acetaminophen for pain relief in pediatric day case tonsillectomy: A randomized double‐blind study. Laryngoscope Investigative Otolaryngology, (2021); 6(6): 1307-1315.
Li X, Zhou P, Li Z, Tang H, Zhai S. Intravenous Parecoxib for Pain Relief after Orthopedic Surgery: A Systematic Review and Meta-analysis. Pain and therapy, (2022); 1-17.
Jerde TJ, Calamon-Dixon JL, Bjorling DE, Nakada SY. Celecoxib inhibits ureteral contractility and prostanoid release. Urology, (2005); 65(1): 185-190.
Chaignat V, Danuser H, Stoffel MH, Z'Brun S, Studer U, et al. Effects of a non‐selective COX inhibitor and selective COX‐2 inhibitors on contractility of human and porcine ureters in vitro and in vivo. British journal of pharmacology, (2008); 154(6): 1297-1307.
Gupta A, Gupta S, Mani R, Durgapal P, Goyal B, Rajput D, et al. Expression of Human epidermal growth factor receptor 2, Survivin, Enhancer of zeste homolog -2, Cyclooxygenase-2, p53 and p16 molecular markers in Gall bladder carcinoma. J Carcinog, (2021);20:7. DOI: 10.4103/jcar.JCar_4_21
Gani IH, Al-Obaidi Z. Molecular docking studies of tyrosine kinase inhibitors: Exemplified protocol to advance pharmaceutical education in medicinal chemistry . Pharmacy Education, (2022). 22(4): 110–114. https://doi.org/10.46542/pe.2022.224.110114
Mousa NO, Gado M, Osman A. Multimodality of human epidermal growth factor receptor-2 antagonism restores the apoptotic capacity of liver cancer cells. J Nat Sc Biol Med, (2020);11:118-27
Rao S, Anthony ML, Chowdhury N, Kathrotia R, Mishra M, Naithani M, Sindhwani G, Singh N. Molecular characterization of lung carcinomas: A study on diagnostic, predictive, and prognostic markers using immunohistochemical analysis at a Tertiary Care Center in Uttarakhand, India. J Carcinog, (2021): 7;20:17. doi: 10.4103/jcar.jcar_14_21. PMID: 34729049; PMCID: PMC8531572.
Simeon J, Thrush J, Bailey TA. Angiopoietin-like protein 4 is a chromatin-bound protein that enhances mammosphere formation in vitro and experimental triple-negative breast cancer brain and liver metastases in vivo. J Carcinog, (2021); 17: 20:8. doi: 10.4103/jcar.JCar_20_20. PMID: 34447288; PMCID: PMC8356708.
Sowmya SV, Rao RS, Prasad K. Prediction of metastasis in oral squamous cell carcinoma through phenotypic evaluation and gene expression of E-cadherin, β-catenin, matrix metalloproteinase-2, and matrix metalloproteinase-9 biomarkers with clinical correlation. J Carcinog, (2020); 6;19:8. doi: 10.4103/jcar.JCar_8_20. PMID: 33033464; PMCID: PMC7511891.
Gasmi A, Noor S, Piscopo S, Menzel A. Lifestyle Genetics-Based Reports in the Treatment of Obesity. Archives of Razi Institute, (2021);76(4):707.
Shnewer Mahdi Al-Turfi Z, Al-Hadrawy S, Abadi Mohammed J, Chasib Jabal B. Evaluation of the Effect of Alcoholic Extract of Laurus Nobilis Leaves on Blood Biochemical Parameters and Histological Changes in the Liver and Kidney among Female Wistar Rats Treated with Depakene (Sodium Valproate). Archives of Razi Institute, (2022); 77(3), 981-989. doi: 10.22092/ari.2022.357272.2011
Sharma G, Sharma SB. Synthetic Impatienol analogues as potential cyclooxygenase-2 inhibitors: a preliminary study. J. Appl. Organomet. Chem., (2021); 1(2), 66-75. doi:10.22034/jaoc.2021.276815.1006
Alghamdi S, Asif M. Pyridazine derivatives act as phosphodiesterase-III, IV, and V Inhibitors. J. Appl. Organomet. Chem., (2021); 1(3), 116-124. doi:10.22034/jaoc.2021.289851.1024
Darabi, H., Baradaran, A., Ebrahimpour, K. Subacute toxic effects of polyvinyl chloride microplastics (PVC-MPs) in juvenile common carp, Cyprinus carpio (Pisces: Cyprinidae). Caspian Journal of Environmental Sciences, (2022); 20(2): 233-242. doi: 10.22124/cjes.2022.5551
Kaliwal, B. B., Ksheerasagar, R. L. Histological and Biochemical Changes in the Liver of Albino Mice on Exposure to Insecticide, Carbosulfan. Caspian Journal of Environmental Sciences, (2006); 4(1): 67-76.
Beiranvand F, Alizadeh M. Plants for Remedies of Diabetes Mellitus in Iran. Plant Biotechnol Persa, (2019); 1 (1): 36-38.
Urainab S, Mehreen A, Zahid S. Essential Oils Have the Potential to Be Effective Therapeutic Agents In The Future. Plant Biotechnol Persa, (2022); 4 (1):18-24.
Abbasi N. Extraction and phytoanalysis of chemical compounds of Eucalyptus globulus leaf native to Dehloran, Ilam province, Iran by HS-SPME and GC-MS." Advances in Animal and Veterinary Sciences, (2020); 8(6): 647-652.
Bahmani M, Jalilian A, Salimikia I, Shahsavari S, Abbasi N. Phytochemical screening of two Ilam native plants Ziziphus nummularia (Burm. f.) Wight & Arn. and Ziziphus spina-christi (Mill.) Georgi using HS-SPME and GC-MS spectroscopy. Plant Science Today, (2020); 6;7(2):275-80.
Khademian amiri SA, Aghajanzadeh T, Jafari N, Mahmoudi M. Antioxidative compounds, enzymes activity and nutrient elements in Stachys byzantina are altered by climate conditions not by soil parameters. Caspian Journal of Environmental Sciences, (2022): 1-17.
Refbacks
- There are currently no refbacks.