An overview of the uses of propolis for oral health
Abstract
Propolis is a gummy agent exploited from bees, which has anti-inflammatory, antibacterial, anti-allergic, wound healing, antidiabetic, and antiviral effects against various injuries and diseases. It also produces antifungal, antitumor and local anesthetic effects. The aim of the review was to review research findings on the role of propolis in oral health. This study was conducted by reviewing published articles on the use of propolis in oral health. To this end, Persian electronic databases such as Google, SID and Magiran as well as English databases such as PubMed and WOS were searched for articles published from 1979 onwards, 140 papers were retrieved, 21 articles were excluded, and 119 articles were included in final review. So far, propolis has been studied for the treatment of surgical wounds, intracanal irrigation, inhibition of the decay process, treatment of periodontitis and dentin hypersensitivity, and potential antifungal and antibacterial activities in the canal with a mostly satisfactory efficacy. Propolis has been reported to improve surgical wounds and produce anti-decay, anti-dentin hypersensitivity and anti-aphthous ulcer properties, and to be useful as a tooth-storing medium after tooth extraction, an intracanal irrigant and a mouthwash. substances highly useful properties of propolis, it can be argued that in the future, the substance will play a substantial role in dental science are necessary to isolate its compounds and identify their beneficial effects.
Full Text:
PDFReferences
Paulino N, Teixeira C, Martins R, Scremin A, Dirsch VM, Vollmar AM, et al. Evaluation of the analgesic and anti-inflammatory effects of a Brazilian green propolis. Planta medica, (2006); 72(10): 899-906.
Sulaiman GM, Al Sammarrae KW, Ad'hiah AH, Zucchetti M, Frapolli R, Bello E, et al. Chemical characterization of Iraqi propolis samples and assessing their antioxidant potentials. Food Chemical Toxicolology, (2011); 49(9): 2415-21.
Lee S, Kim KS, Park Y, Shin KH, Kim BK. In vivo anti-oxidant activities of tectochrysin. Archiv of Pharmacalogical Research, (2003); 26(1): 43-6.
Bankova VS, Castro SLd, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie, (2000); 31(1): 3-15.
de Barros MP, Sousa JP, Bastos JK, de Andrade SF. Effect of Brazilian green propolis on experimental gastric ulcers in rats. Journal of Ethnopharmacology, (2007); 110(3): 567-71.
Koo H, Vacca Smith AM, Bowen WH, Rosalen PL, Cury JA, Park YK. Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatite. Caries Research, (2000); 34(5):418-26.
Marcucci MC. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie, (1995);26(2):83-99.
Khalil ML. Biological activity of bee propolis in health and disease. Asian Pacific journal of cancer prevention: APJCP, (2006);7(1):22-31.
Murata K, Yatsunami K, Fukuda E, Onodera S, Mizukami O, Hoshino G, et al. Antihyperglycemic effects of propolis mixed with mulberry leaf extract on patients with type 2 diabetes. Alternative Therapies Health Medicine, (2004);10(3):78-9.
Paintz M, Metzner J. On the local anaesthetic action of propolis and some of its constituents. Die Pharmazie, (1979);34(12):839-41.
Alyane M, Kebsa LB, Boussenane H, Rouibah H, Lahouel M. Cardioprotective effects and mechanism of action of polyphenols extracted from propolis against doxorubicin toxicity. Pakistan Journal of Pharmaceutical Sciences, (2008); 21(3): 201-9.
Magro Filho O, de Carvalho AC. Application of propolis to dental sockets and skin wounds. The Journal of Nihon University School of Dentistry, (1990);32(1):4-13.
Martin MP, Pileggi R. A quantitative analysis of Propolis: a promising new storage media following avulsion. Dental Traumatology, (2004); 20(2): 85-9.
Ozan F, Polat ZA, Er K, Ozan U, Değer O. Effect of propolis on survival of periodontal ligament cells: new storage media for avulsed teeth. Journal of Endodontics, (2007); 33(5): 570-3.
Gopikrishna V, Baweja PS, Venkateshbabu N, Thomas T, Kandaswamy D. Comparison of coconut water, propolis, HBSS, and milk on PDL cell survival. Journal of Endodontics, (2008);34(5):587-9.
Al-Shaher A, Wallace J, Agarwal S, Bretz W, Baugh D. Effect of propolis on human fibroblasts from the pulp and periodontal ligament. Journal of Endodontics, (2004); 30(5): 359-61.
Al-Qathami H, Almadi E. A Comparison of Sodium Hypochlorite, Propolis and saline as a root canal irrigant: SEM Study, (2004); 62-5.
Ozan F, Sümer Z, Polat ZA, Er K, Ozan U, Deger O. Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts. European Journal of Dentistry, (2007); 1(4): 195-201.
Hayacibara MF, Koo H, Rosalen PL, Duarte S, Franco EM, Bowen WH, et al. In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development. Journal of Ethnopharmacology, (2005); 101(1-3): 110-5.
Hidaka S, Okamoto Y, Ishiyama K, Hashimoto K. Inhibition of the formation of oral calcium phosphate precipitates: the possible effects of certain honeybee products. Journal of Periodontal Research, (2008); 43(4): 450-8.
Toker H, Ozan F, Ozer H, Ozdemir H, Eren K, Yeler H. A morphometric and histopathologic evaluation of the effects of propolis on alveolar bone loss in experimental periodontitis in rats. Journal of Eeriodontology, (2008);79(6):1089-94.
Murray MC, Worthington HV, Blinkhorn AS. A study to investigate the effect of a propolis-containing mouthrinse on the inhibition of de novo plaque formation. Journal of Clinical Periodontology, (1997); 24(11): 796-8.
Martins RS, Péreira ES, Jr., Lima SM, Senna MI, Mesquita RA, Santos VR. Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis. Journal of Oral Sciences, (2002); 44(1): 41-8.
Momen-Beitollahi J, Mansorian A, Esmaili M, Amanlou M, Mohamadnia A, Bahrami N. Antimicrobial effects of propolis extract on the most prevalent oral pathogens: An in vitro study. Journal of Iran Dental Association, (2009);21(1):33-9.
Santos VR, Gomes RT, de Mesquita RA, de Moura MD, França EC, de Aguiar EG, et al. Efficacy of Brazilian propolis gel for the management of denture stomatitis: a pilot study. Phytotherapy Research, (2008); 22(11): 1544-7.
Oncag O, Cogulu D, Uzel A, Sorkun K. Efficacy of propolis as an intracanal medicament against Enterococcus faecalis. General Dentology, (2006);54(5):319-22.
Awawdeh L, Al-Beitawi M, Hammad M. Effectiveness of propolis and calcium hydroxide as a short-term intracanal medicament against Enterococcus faecalis: a laboratory study. Australian Endodontic Journal, (2009);35(2):52-8.
Ahangari Z, Eslami G, Koosedghi H, Ayatolahi A. Comparative study of antibacterial activity of propolis and Ca(OH)2 against lactobacillus, entrococus feacalis, peptostreptococus and candida albicans. Journal of Iran Dental Association 2009; 21(1) :50-56
Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N. The effect of bee propolis on recurrent aphthous stomatitis: a pilot study. Clinical Oral Investigations, (2007);11(2):143-7.
Mahmoud AS, Almas K, Dahlan AA. The effect of propolis on dentinal hypersensitivity and level of satisfaction among patients from a university hospital Riyadh, Saudi Arabia. Indian Journal of Dental Reseach, (1999); 10(4): 130-7.
Parolia A, Kundabala M, Rao NN, Acharya SR, Agrawal P, Mohan M, et al. A comparative histological analysis of human pulp following direct pulp capping with Propolis, mineral trioxide aggregate and Dycal. Australian Dental Journal, (2010);55(1):59-64.
Sales-Peres SH, Carvalho FN, Marsicano JA, Mattos MC, Pereira JC, Forim MR, et al. Effect of propolis gel on the in vitro reduction of dentin permeability. Journal of Applied Oral Science, (2011);19(4):318-23.
Troca VB, Fernandes KB, Terrile AE, Marcucci MC, Andrade FB, Wang L. Effect of green propolis addition to physical mechanical properties of glass ionomer cements. Journal of Applied Oral Science, (2011); 19(2): 100-5.
Bertolini PF, Biondi Filho O, Pomilio A, Pinheiro SL, Carvalho MS. Antimicrobial capacity of Aloe vera and propolis dentifrice against Streptococcus mutans strains in toothbrushes: an in vitro study. Journal of Applied Oral Sciences, (2012); 20(1): 32-7.
Mattigatti S, Ratnakar P, Moturi S, Varma S, Rairam S. Antimicrobial effect of conventional root canal medicaments vs propolis against Enterococcus faecalis, Staphylococcus aureus and Candida albicans. Journal of Contemporary Dental Practice, (2012);13(3):305-9.
Ramos IF, Biz MT, Paulino N, Scremin A, Della Bona A, Barletta FB, et al. Histopathological analysis of corticosteroid-antibiotic preparation and propolis paste formulation as intracanal medication after pulpectomy: an in vivo study. Journal of Applied Oral Sciences, (2012); 20(1): 50-6.
Altan BA, Kara IM, Nalcaci R, Ozan F, Erdogan SM, Ozkut MM, et al. Systemic propolis stimulates new bone formation at the expanded suture: a histomorphometric study. The Angle orthodontist, (2013);83(2):286-91.
Jolly M, Singh N, Rathore M, Tandon S, Banerjee M. Propolis and commonly used intracanal irrigants: comparative evaluation of antimicrobial potential. Journal of Clinical Pediatric Dentistry, (2013);37(3):243-9.
Mahal NK, Singh N, Thomas AM, Kakkar N. Effect of three different storage media on survival of periodontal ligament cells using collagenase-dispase assay. International Endodontic Journal, (2013); 46(4): 365-70.
Tomaževič T, Jazbec J. A double blind randomised placebo controlled study of propolis (bee glue) effectiveness in the treatment of severe oral mucositis in chemotherapy treated children. Complementary Therapies Medicine, (2013);21(4):306-12.
AkhavanKarbassi MH, Yazdi MF, Ahadian H, SadrAbad MJ. Randomized DoubleBlind PlaceboControlled Trial of Propolis for Oral Mucositis in Patients Receiving Chemotherapy for Head and Neck Cancer. Asian Pacific Journal of Cancer Prevention, (2016);17(7):3611-4.
Bretz WA, Paulino N, Nör JE, Moreira A. The effectiveness of propolis on gingivitis: a randomized controlled trial. Journal of Alternative and Complementary Medicine, (2014); 20(12): 943-8.
Tulsani SG, Chikkanarasaiah N, Siddaiah SB, Krishnamurthy NH. The effect of Propolis and Xylitol chewing gums on salivary Streptococcus mutans count: a clinical trial. Indian Journal of Dentalogy, (2014);25(6):737-41.
Zare Jahromi M, Ranjbarian P, Shiravi S. Cytotoxicity evaluation of Iranian propolis and calcium hydroxide on dental pulp fibroblasts. Journal of Dental Research, Dental Clinics, Dental Prospects, (2014); 8(3): 130-3.
El-Sharkawy HM, Anees MM, Van Dyke TE. Propolis Improves Periodontal Status and Glycemic Control in Patients with Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial. Journal of Periodontology, (2016);87(12):1418-26.
Niedzielska I, Puszczewicz Z, Mertas A, Niedzielski D, Różanowski B, Baron S, et al. The Influence of Ethanolic Extract of Brazilian Green Propolis Gel on Hygiene and Oral Microbiota in Patients after Mandible Fractures. BioMed Research International, (2016): 9190814.
Sabir A, Sumidarti A. Interleukin-6 expression on inflamed rat dental pulp tissue after capped with Trigona sp. propolis from south Sulawesi, Indonesia. Saudi Journal of Biological Sciences, (2017); 24(5): 1034-7.
Shabbir J, Qazi F, Farooqui W, Ahmed S, Zehra T, Khurshid Z. Effect of Chinese Propolis as an Intracanal Medicament on Post-Operative Endodontic Pain: A Double-Blind Randomized Controlled Trial. International Journal of Environmental Research Public Health, (2020); 17(2): 3-9.
Bapat S, Nagarajappa R, Ramesh G, Bapat K. Effect of propolis mouth rinse on oral microorganisms - a randomized controlled trial. Clinical Oral Investing, (2021); 25(11): 6139-46.
González-Serrano J, López-Pintor RM, Serrano J, Torres J, Hernández G, Sanz M. Short-term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri-implant mucositis: A double-blind, randomized, clinical trial. Journal of Periodontal Reseach, (2021);56(5):897-906.
Machorowska-Pieniążek A, Morawiec T, Olek M, Mertas A, Aebisher D, Bartusik-Aebisher D, et al. Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients. Biomedicine and Pharmacotherapy, (2021); 142: 111992.
Papp Z, Bouchelaghem S, Szekeres A, Meszéna R, Gyöngyi Z, Papp G. The Scent of Antifungal Propolis. Sensors, (2021); 21(7): 3.
Park JY, Ko KA, Lee JY, Oh JW, Lim HC, Lee DW, et al. Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial. Nutrients, (2021);13(8): 4-6.
de Faveri M, Pupio GC, Koo H, Bueno-Silva B, de Oliveira KM, Figueiredo LC, et al. The effect of Brazilian propolis type-3 against oral microbiota and volatile sulfur compounds in subjects with morning breath malodor. Clinical Oral Investigations, (2022); 26(2): 1531-41.
Neto EMR, Valadas LAR, Lobo PLD, Fernandes AMB, da Cruz Fonseca SG, Fechine FV, et al. Dose-response Evaluation of Propolis Dental Varnish in Children: A Randomized Control Study. Recent Patents Biotechnology, (2020); 14(1): 41-8.
Kiani S, Birang R, Jamshidian N. Effect of Propolis mouthwash on clinical periodontal parameters in patients with gingivitis: A double-blinded randomized clinical trial. International Journal of Dental Hygiene, (2022); 20(2): 434-40.
Lotif MAL, Valadas LAR, Fechine FV, Fonseca SGC, Bandeira MAM, Dantas T, et al. A double-blind randomized clinical trial of Brazilian red propolis dentifrice efficacy in orthodontic patients. Journal of Oral Sciences, (2022); 64(1): 28-32.
Duarte S, Rosalen PL, Hayacibara MF, Cury JA, Bowen WH, Marquis RE, et al. The influence of a novel propolis on mutans streptococci biofilms and caries development in rats. Archiv of Oral Sciences, (2006);51(1):15-22.
Park YK, Koo MH, Abreu JA, Ikegaki M, Cury JA, Rosalen PL. Antimicrobial activity of propolis on oral microorganisms. Current Microbiology, (1998); 36(1): 24-8.
Hamad MH, Hadi ME, Alsaffar MF. Effects of some alcoholic extracts of propolis in ovulation and fertility rate of the ovary and oviduct in quail. Caspian Journal of Environmental Sciences, (2023); 21(2): 317-323.
Akbarzadeh A, Baniesmaeeili SY, Riazi G, Abdollahi F, Niromand M. Effects of dietary Moringa oleifera leaf powder and ethanolic extract on expression function of immune genes of Litopenaeus vannamei. Aquatic Animals Nutrition, )2023(; 9(1):27-41
Koru O, Toksoy F, Acikel CH, Tunca YM, Baysallar M, Uskudar Guclu A, et al. In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens. Anaerobe, (2007);13(3-4):140-5.
Elbaz GA, Elsayad, II. Comparison of the antimicrobial effect of Egyptian propolis vs New Zealand propolis on Streptococcus mutans and lactobacilli in saliva. Oral Health Preventive Dentistry, (2012);10(2):155-60.
Koo H, Rosalen PL, Cury JA, Park YK, Ikegaki M, Sattler A. Effect of Apis mellifera propolis from two Brazilian regions on caries development in desalivated rats. Caries Research, (1999);33(5):393-400.
Ashry el SH, Ahmad TA. The use of propolis as vaccine's adjuvant. Vaccine, (2012);31(1):31-9.
Mori GG, Nunes DC, Castilho LR, de Moraes IG, Poi WR. Propolis as storage media for avulsed teeth: microscopic and morphometric analysis in rats. Dental Traumatology, (2010);26(1):80-5.
Casaroto AR, Hidalgo MM, Sell AM, Franco SL, Cuman RK, Moreschi E, et al. Study of the effectiveness of propolis extract as a storage medium for avulsed teeth. Dental Toxicology, (2010); 26(4):323-31.
Gjertsen AW, Stothz KA, Neiva KG, Pileggi R. Effect of propolis on proliferation and apoptosis of periodontal ligament fibroblasts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, (2011);112(6):843-8.
Pileggi R, Antony K, Johnson K, Zuo J, Holliday LS. Propolis inhibits osteoclast maturation. Dental Traumatology, (20090;25(6):584-8.
Saxena P, Pant VA, Wadhwani KK, Kashyap MP, Gupta SK, Pant AB. Potential of the propolis as storage medium to preserve the viability of cultured human periodontal ligament cells: an in vitro study. Dental Traumatology, (2011); 27(2): 102-8.
Cury JA, Rebelo MA, Del Bel Cury AA, Derbyshire MT, Tabchoury CP. Biochemical composition and cariogenicity of dental plaque formed in the presence of sucrose or glucose and fructose. Caries Research, (2000);34(6):491-7.
Coutinho A. Honeybee propolis extract in periodontal treatment: a clinical and microbiological study of propolis in periodontal treatment. Indian Journal of Dental Research, (2012);23(2):294.
Gebaraa EC, Pustiglioni AN, de Lima LA, Mayer MP. Propolis extract as an adjuvant to periodontal treatment. Oral Health Preventive Dentistry, (2003);1(1):29-35.
Shahsavari S, Sarkar S, Sen DJ, Mandal SK. Determination of total antioxidant activity of methanolic extract of Falcaria vulgaris. Journal of Biochemistry and Phytomedicine, (2022); 1(1): 8–12.
Podbielski A, Spahr A, Haller B. Additive antimicrobial activity of calcium hydroxide and chlorhexidine on common endodontic bacterial pathogens. Journal of Endodontics, (2003);29(5):340-5.
Arslan S, Ozbilge H, Kaya EG, Er O. In vitro antimicrobial activity of propolis, BioPure MTAD, sodium hypochlorite, and chlorhexidine on Enterococcus faecalis and Candida albicans. Saudi Medical Journal, (2011); 32(5): 479-83.
Sabir A, Tabbu CR, Agustiono P, Sosroseno W. Histological analysis of rat dental pulp tissue capped with propolis. Journal of Oral Sciences, (2005);47(3):135-8.
Hehlgans S, Lange I, Eke I, Kammerer B, Cordes N. Human head and neck squamous cell carcinoma cell lines are differentially radiosensitised by the honeybee product Propolis. International Journal of Radiation Biology, (2011);87(3):243-53.
Magro-Filho O, de Carvalho AC. Topical effect of propolis in the repair of sulcoplasties by the modified Kazanjian technique. Cytological and clinical evaluation. Journal Nihon University School Dental, (1994);36(2):102-11.
Velazquez C, Navarro M, Acosta A, Angulo A, Dominguez Z, Robles R, et al. Antibacterial and free-radical scavenging activities of Sonoran propolis. Journal of Applied Microbiology, (2007);103(5):1747-56.
Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. Journal of Ethnopharmacology, (1999);64(3):235-40.
Simúth J, Trnovský J, Jeloková J. Inhibition of bacterial DNA-dependent RNA polymerases and restriction endonuclease by UV-absorbing components from propolis. Die Pharmazie, (1986);41(2):131-2.
Walgrave SE, Warshaw EM, Glesne LA. Allergic contact dermatitis from propolis. Dermatitis : contact, atopic, occupational, Drug, (2005);16(4):209-15.
Borrelli F, Maffia P, Pinto L, Ianaro A, Russo A, Capasso F, et al. Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia, (2002);73 Suppl 1: 53-63.
Darvishi M, Nazer MR, Alipour MR. Investigating the end of patients suffering from diabetic foot hospitalized in Be'sat hospital of IRIAF from 2009 to 2014. Biomedical Research India. (2017); 1; 28:4630-3.
Forootan M, Tabatabaeefar M, Mosaffa N, Ashkalak HR, Darvishi M. Investigating esophageal stent-placement outcomes in patients with inoperable non-cervical esophageal cancer. Journal of Cancer, (2018);9(1):213.
Darvishi M, Ziari K, Mohebbi H, Alizadeh K. Association between iron deficiency anemia and Helicobacter pylori infection among children under six years in Iran. Acta Medica Iranica, (2015); 220-4.
Jalalmanesh S, Darvishi M, Rahimi M, Akhlaghdoust M. Contamination of senior medical students’ cell phones by nosocomial infections: a survey in a university-affiliated Hospital in Tehran. Shiraz E-Medical Journal, (2017); 30;18(4).
Darvishi M, Forootan M, Nazer MR, Karimi E, Noori M. Nosocomial Infections, Challenges and Threats: A Review Article. Iranian Journal of Medical microbiology, (2020);10;14(2):162-81.
Darvishi M. Antibiotic resistance pattern of uropathogenic methicillin-resistant staphylococcus aureus isolated from immunosuppressive patients with pyelonephritis. Journal of Pure and Applied Microbiology, (2016); (1;10(4):2663-7.
Hamad MH, Hadi ME, Alsaffar MF. Effects of some alcoholic extracts of propolis in ovulation and fertility rate of the ovary and oviduct in quail. Caspian Journal of Environmental Sciences, (2023); 21(2): 317-323.
Ghytasi A, Hosseini Shekarabi SP, Rajabi Islami H, Shamsaie Mehrgan M. Dietary effects of lemon Citrus limon peel essential oil encapsulated in chitosan nanoparticles on hematological indices and antioxidant defense system of rainbow trout Oncorhynchus mykiss. Aquatic Animals Nutrition, (2021); 7(1): 27-41.
Yeganeh S, Adel M. Effects of dietary rainbow trout visceral protein hydrolysate on hematological, immunological and biochemical serum parameters and antioxidant enzymes of juvenile Siberian sturgeon, Acipenser baerii. Aquatic Animals Nutrition, (2021); 7(4): 43-60.
Shahsavari S, Kumar Mandal S, Kumar D. Determination of antioxidant capacity of methanolic extract of Allium ampeloprasum subsp Iranicum. Journal of Biochemicals and Phytomedicine, )2023(; 2(1): 3-6.
Hanifi E, Ahmadifard N, Atashbar B, Meshkini S. Effects of zinc oxide nanoparticles on photosynthetic pigments, zinc accumulation, and activity of antioxidant enzymes of Dunalilla salina. Aquatic Animals Nutrition, (2022); 8(4): 31-42.
DOI: http://dx.doi.org/10.62940/als.v10i4.1608
Refbacks
- There are currently no refbacks.