Association between polymorphism of the CRP gene rs1130864 and hypertension among Iraqi hypertensive patients
Abstract
Background: C-reactive protein (CRP) a reactant of the acute phase and a measure of persistent low-grade inflammatory processes. Objectives of this paper to the role of rs1130864 polymorphism in CRP gene among Iraqi hypertensive patients.
Methods: Samples of blood were collected from patients with hypertension and controls, their age (37 to 75). Hardy-Weinberg equilibrium (HWE) was used to calculate the risk score for the disease of hypertension, Moreover, PCR/SNP (specific primers) was used to do genotyping.
Results: HWE analysis of hypertensive patients and controls showed that the rs1130864 genotypes were in agreement with the equilibrium, without differences clear between the observed and expected genotype frequencies (p >0.153, 0.238). The frequencies of genotype and alleles were compared in hypertensive patients with controls, with no significant differences. The common GG genotype of rs1130864 recorded a significant increase in hypertensive patients and controls and was regarded as a preventative fraction (RR = 0.76), whilst, GA , AA genotype were considered the etiological fraction (RR = 1.06, 2.59) and associated with hypertension. Compared to A allele, which might be the cause of the disease, G allele might be preventive.
Conclusion: The findings showed that the Iraqi population's GA, AA genotype, and A allele are risk factors for hypertension. However, the need for additional findings utilizing bigger samples is needed are necessary to verify our findings.
Keywords: Hypertension; C-reactive protein; Polymorphism, 1444G>A; rs1130864
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DOI: http://dx.doi.org/10.62940/als.v10i2.1770
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