The effects of 4β-hydroxy withanolide E extracted from Physalis Peruviana on Complete Blood Count of Dimethylbenz(a)anthracene-induced Breast Cancer in Albino Rats

Fahmida Gul, Samreen Memon, Ikramuddin Ujjan, Pushpa Goswami, Kanwal Abbas Bhatti


Background: Several studies reveal changes in blood parameters in patients with cancer. Complete blood count is a good predictor for many cancer diagnoses and prognoses. They are also helpful in assessing drug efficacy and toxicity. Cancers may be treated with bioactive and antioxidant compounds derived from plants. The effects of Physalis peruviana on the complete blood count of dimethylbenz(a)anthracene induced are still not well identified.

Methods: This study was conducted at Liaquat University of Medical and Health Sciences, Jamshoro, for six months on 60 female albino rats divided in 05 groups. The effects of Physalis peruviana fruits and tamoxifen on complete blood count in dimethylbenz(a)anthracene induced breast cancer were assessed. Blood samples were collected at weeks 1, 5, 7, and 10 for hematological changes before, during, and after treatment.

Result: Rats of group E (Tumor-induced albino rats treated with the extracts of Physalis Peruviana and tamoxifen) gave the best results compared to other groups. In this group, increases in weight along with an improvement in hematological parameters were observed when compared with others.

Conclusion: The extract from Physalis Peruviana helps in the reversal of pancytopenia with anemia and thrombocytopenia caused by tumor-inducing drugs.

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