Histological study of the parenchymatous cells in mice parotid salivary glands exposed to dental radiograph
Abstract
Background: Ionizing radiation has been linked to an increased incidence of salivary gland cancers and xerostomia. Saliva has antibacterial and enzymatic properties, and the parotid glands are made up of serous acini. Myoepithelial cells are essential for acinar salivary secretion.
Methods: This research investigated the potential risks associated with dental X-rays and provided evidence-based recommendations for safe use. It was found that exposure to radiation causes a decline in hemoglobin binding to the erythrocyte membrane.
Results: Dental X-ray exposure causes acute inflammatory destruction, and alterations do not fully restore the parotid tissue histology.
Conclusion: Even low doses of radiation from dental X-rays can increase the risk of developing cancer and other health problems, and further studies are needed to mitigate these effects and improve patient outcomes.
Full Text:
PDFReferences
Chibly AM, Aure MH, Patel VN, Hoffman MPJPR. Salivary gland function, development, and regeneration. Physiological Reviews, (2022); 102(3): 1495-1552.
Chattopadhyay I, Verma M, Panda MJTicr, treatment. Role of oral microbiome signatures in diagnosis and prognosis of oral cancer. Technology in cancer research & treatment, (2019); 181533033819867354.
Gardner A (2020) The Influence of Salivary Metabolite Composition on Taste and Oral Perception: King's College London.
AL-Hashemi WH, Mansur ME, Homady MHJBCA. Intracomparative And Immunocytochemistry Study Of Parotid, Submandibular And Sublingual Gland In Domestic Rabbit Of Iraq. Biochemical & Cellular Archives, (2019); 19(1): 1069-1090.
Kanitakis JJEjod. Anatomy, histology and immunohistochemistry of normal human skin. European journal of dermatology, (2002); 12(4): 390-401.
Contreras-Aguilar MD, Gómez-García FJSiH, Present DT, Diagnosis FoaUSf. Salivary glands’ anatomy and physiology. Saliva in Health and Disease: The Present and Future of a Unique Sample for Diagnosis, (2020); 3-21.
Maldonado JO, Pérez Riveros P, Chiorini JA (2021). Myoepithelial Cell Function in Salivary Gland Physiology and Disease. Sjögren's Syndrome and Oral Health: Disease Characteristics and Management of Oral Manifestations: Springer. pp. 59-69.
de Paula F, Teshima THN, Hsieh R, Souza MM, Nico MMS, et al. Overview of human salivary glands: highlights of morphology and developing processes. The Anatomical Record, (2017); 300(7): 1180-1188.
Cano IP, Dionisio TJ, Cestari TM, Calvo AM, Colombini-Ishikiriama BL, et al. Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands. PLoS One, (2019); 14(5): e0217030.
Song E, Smalley K, Oyelakin A, Horeth E, Che M, et al. Genetic study of Elf5 and ehf in the mouse salivary gland. Journal of Dental Research, (2023); 102(3): 340-348.
Bhat M (2021) A Clinical Study on the Efficacy of Jaloukavacharana and Siravyadha by Kutharika Shastra in the Management of Sirajagranthi WSR to Varicose Vein: Rajiv Gandhi University of Health Sciences (India).
Shalaby AM, Alnasser SM, Khairy DA, Alabiad MA, Alorini M, et al. The neuroprotective effect of ginsenoside Rb1 on the cerebral cortex changes induced by aluminium chloride in a mouse model of Alzheimer's disease: A histological, immunohistochemical, and biochemical study. Journal of Chemical Neuroanatomy, (2023); 129102248.
Hadi RJ (2020) Evaluation of Pulp Response to In-Office Bleaching Technique by Histological and Immunohistochemical (Substance P) Studies in Rats: College of Dentistry Evaluation of Pulp Response to In-Office Bleaching.
Skálová A, Gnepp DR, Lewis JS, Hunt JL, Bishop JA, et al. Newly described entities in salivary gland pathology. The American journal of surgical pathology, (2017); 41(8): e33-e47.
Thoolen B, Maronpot RR, Harada T, Nyska A, Rousseaux C, et al. Proliferative and nonproliferative lesions of the rat and mouse hepatobiliary system. Toxicologic pathology, (2010); 38(7_suppl): 5S-81S.
El-Naseery NI, Elewa YH, Arafa MA, Sabbah W, Dessouky AAJAoA-AA. Mesenchymal stem cells enhance AQP1 expression in the sublingual salivary gland of ovariectomized menopausal rat model. Annals of Anatomy-Anatomischer Anzeiger, (2021); 236151714.
Shredah MT, Nagy DAJEDJ. Effect of monosodium glutamate on the sublingual salivary glands of rats (histological and histochemical study). Egyptian Dental Journal, (2017); 63(4-October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 3263-3270.
Stewart F, Akleyev A, Hauer-Jensen M, Hendry J, Kleiman N, et al. ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs—threshold doses for tissue reactions in a radiation protection context. Annals of the ICRP, (2012); 41(1-2): 1-322.
Sheaff M (2011) The role of platelet-derived growth factor in radiation injury to the lower urinary tract: Queen Mary University of London.
Safak G, Celiker M, Tümkaya L, Mercantepe T, Rakici S, et al. Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage. Radiation and Environmental Biophysics, (2022); 61(2): 241-253.
Refbacks
- There are currently no refbacks.