Correlation between Neutrophil Gelatinase Associated with Lipocaline and Megalin in Type 2 Diabetic patients

Duaa Abdul-Jabbar Dawood, Emad Mohamed Rasheed, Ahmad Saadi Hassan

Abstract


Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder defined via elevated blood glucose caused by insufficiency of insulin-sensitive tissues to respond to insulin or defective insulin production by pancreatic β-cells due to environmental and genetic factors. Megalin is a glycoprotein that is mostly found in the proximal tubular cells, major role is to reabsorb albumin and other proteins that the glomerulus has filtered in the proximal tubules.

Methods: The purpose of research measure the concentration of megalin and Neutrophil Gelatinase Associated Lipocalin (NGAL) in type 2 patients, in the period from December 2022 to March 2023 at the Baghdad Teaching Hospital120 participants aged(30-60) years, the measured concentration of Megalin, NGAL, and fasting blood glucose in serum and whole blood estimated for glycated hemoglobin (HbA1C).

Results: The result indicates blood glucose concentration in patients with T2DM (344.975±63.68mg/dl) was significantly higher than control(106.62±12.59mg/dl), HbA1C (13.40±10.35%) in T2DM patients was significantly higher than control (4.310±0.336%), Megalin levels revealed for T2DM patients (220.70±42.47pg/ml) significantly higher than control (120.42±29.33pg/ml), NGAL(447.68±62.76pg/ml) in T2DM patients higher than control(264.93±51.79 pg/ml).

Conclusion: According to the results NGAL and Megalin levels were significantly higher in T2DM patients as compared to controls play a role in diabetes pathogenesis and as biomarkers for the early identification of diabetic nephropathy.


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References


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