Effect of Vitamin D3 Levels on Varicella-Zoster Virus Infection and IFN-Gamma Expression in Children: A Cross-Sectional Study in Iraq

Maitham G. Yousif, Fadhil G. Al-Amran, Salman Rawaf, Dhiya Al-Jumeily

Abstract


Background: This study aimed to explore the correlation between Vitamin D3 levels and IFN-Gamma expression in children residing in the southern and central provinces of Iraq. Vitamin D3 plays a pivotal role in immune function, and IFN-Gamma is a crucial cytokine involved in antiviral defense. Investigating the connection between Vitamin D3 and IFN-Gamma offers valuable insights into immune responses and potential implications for infectious diseases.

Methods: A case-control study was conducted, involving children from various schools and kindergartens in the southern and central provinces of Iraq. The study assessed Vitamin D3 levels and measured IFN-Gamma expression. Statistical analyses were performed to determine the relationship between these variables.

Results: The outcomes revealed a significant positive correlation between Vitamin D3 levels and IFN-Gamma expression within the study population (p < 0.05). Children with higher Vitamin D3 levels exhibited elevated IFN-Gamma expression, suggesting a possible immunomodulatory impact of Vitamin D3 on IFN-Gamma production.

Conclusion:These findings underscore the importance of maintaining adequate Vitamin D3 levels to support immune function, particularly in relation to IFN-Gamma expression. Improving Vitamin D3 status could potentially bolster antiviral defense mechanisms and reduce susceptibility to viral infections among children in the southern and central provinces of Iraq. Further investigation is warranted to delve into the underlying mechanisms and potential clinical ramifications of this significant association. Additionally, exploring the long-term effects of maintaining optimal Vitamin D3 levels on immune function and the outcomes of infectious diseases in this population would offer valuable insights for preventive and therapeutic strategies.

 


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References


Holick, MF. Vitamin D deficiency. New England Journal of Medicine, (2007); 357(3): 266-281.

Hewison, M. Vitamin D and the immune system: New perspectives on an old theme. Endocrinology and Metabolism Clinics, (2012);41(2): 365-379.

Freer G, Pistello M. Varicella-zoster virus infection: natural history, clinical manifestations, immunity and current and future vaccination strategies. New Microbiologica, (2018);41(2): 95-105.

Santosh AB, Muddana K. Viral infections of oral cavity. Journal of family medicine and primary care, (2020); 9(1): 36.

Yousif MG, Sadeq AM, Alfadhel SM, Al-Amran FG, Al-Jumeily D. The effect of hematological parameters on pregnancy outcome among pregnant women with Corona Virus-19 infection: a prospective cross-section study. Journal of Survey in Fisheries Sciences, (2023); 10(3S): 1425-35.

Sadiq AM, Hussein CM, Yousif M, Mohammed R. Correlation between highly sensitive C-reactive protein level in cases of preeclampsia with or without intrauterine-growth restriction. Indian Journal of Forensic Medicine & Toxicology, (2020); 14(4): 6012.

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, & Camargo Jr CA. Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data. British Medical Journal (BMJ), (2017); 356: i6583.

Schmidt CS, et al. Bacterial infection-associated immunosuppression: From molecular mechanisms to clinical impact. Critical Reviews in Immunology, (2006); 26(4): 317-333.

Aranow C. Vitamin D and the immune system. Journal of Investigative Medicine, (2011); 59(6): 881–886.

Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, & Bhattoa HP. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients, (2021); 12(4): 988.

Al-Jibouri KJ, Yousif MG, Sadeq AM, Al-Jumeily D. Psycho-immunological status of patients recovered from SARS-Cov-2. Journal of Survey in Fisheries Sciences, (2023); 10(3S): 1409-17.

Hosking MP, Warner TA, Lane TE, & Youn HS. Cytokines, chemokines, and other biomarkers of response to treatment for viral infection. Advances in Protein Chemistry and Structural Biology, (2019); Vol. 118: 297–328.

Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, ... & Camargo Jr CA. Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health Technology Assessment, (2017); 21(2): 1–44.

Yousif NG, Younis Z, Al-Amran FG, Yousif MG, Altimim A, Hadi NR. Paeoniflorin attenuates myocardial ischemia/reperfusion injury via up-regulation of notch 1 mediated jagged1 signaling. Systematic Reviews in Pharmacy, (2020); 11(2): 363-71.

Yousif MG, Al-Shamari AK, Sadiq AM. Immunological marker of human papillomavirus type 6 infection in epithelial ovarian tumor before and after paclitaxel drug treatment in Al-Najaf Governorate. Drug Invention Today, (2019); 12.

Yousif MG, Hashim K, & Rawaf S. Post COVID-19 Effect on Medical Staff and Doctors' Productivity Analysed by Machine Learning. Baghdad Science Journal, (2023); 20(4 (SI)): 1507-1507.

Hadi NR, Al-Amran FG, Alrekabi MD, Yousif MG, & Hussein FH. Methionine protects from myocardial ischemia/reperfusion injury via down regulation of the inflammatory response and apoptosis. American Journal of BioMedicine, (2014); 2(1): 36-47.

Sadeq AM, Mohammed FA, Hussein CM, Yousif MG. Renal Function Tests in Women with Preeclampsia with and without Intrauterine Growth Restriction. Indian Journal of Forensic Medicine & Toxicology, (2020); 1:14(4), 6017-6024.

Yousif NG, Younis Z, Al-Amran FG, Yousif MG, Altimim A, Hadi NR. Paeoniflorin Attenuates Myocardial Ischemia/Reperfusion Injury via Up-Regulation of Notch 1-Mediated Jagged1 Signaling. Systematic Reviews in Pharmacy, (2020) ; 11(2): 363- 371.


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