Immunomodulatory Role of Cytokines in Periodontal Disease

Abstract

    Periodontal disease is an inflammatory condition that affects the periodontium and results in the destruction of periodontal tissue. Immune reaction against products of bacteria and the resulting generation of inflammatory cytokines, are significant contributors to periodontal tissue injury. In this disease inflammatory cytokines are generated by immune cells to attack the periodontal bacteria. A persistent or strong immune response may cause inflammation and the creation of cytokines that are essential in the development of periodontitis, even though the immune response can defend an organism from a variety of diseases. Clarifying the immunomodulatory role of cytokines in periodontitis was the main goal of this review.