Investigating the role of heat shock protein HSP60 in coronary artery disease patients infected with Helicobacter pylori

Muntadher Abdulateef Alhasan, Manal Badi Salih

Abstract


Background: Coronary artery disease is a disorder of the heart and blood vessels caused by the hardening or blockage of the coronary arteries. Elevated blood cholesterol, high blood sugar, and high blood pressure are prominent risk factors that contribute to the development of arterial hardening. Evaluation of heat shock protein 60 levels in patients with coronary artery disease infected with Helicobacter pylori bacteria and comparison of the results with non-infected patients and the control group.

Methods: This study was conducted in Nasiriyah Heart Center and Nasiriyah Teaching Hospital in Nasiriyah. A total of 150 samples were collected and divided into three groups: the first group consisted of patients with coronary artery disease infected with Helicobacter pylori bacteria, the second group consisted of patients with coronary artery disease but not infected with Helicobacter pylori, and the third group served as the control group. H. Pylori infection was determined in serum. Heat shock protein-60 levels were determined using enzyme-linked immunosorbent assay.

Results: The level of heat shock protein-60 in the first group was higher than that of the second and third groups, where (P = ≤0.001) and (LSD= 1.86).

Conclusion: Infection with certain pathogenic factors, such as bacteria, can lead to inflammation of the blood vessel lining, which in turn affects the development of coronary artery disease. Consequently, inflammatory factors can increase the cellular expression of heat shock proteins as a result of oxidative stress or inflammation. These heat shock proteins are then displayed on the cell surface and contribute to the presence of heat shock proteins in the blood. Efforts should be made to study heat shock proteins resulting from infection with pathogens, and their role in coronary artery disease and other heart diseases.


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References


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