Evaluation of the produced flavone's protective properties against oxidative stress and dyslipidemia in male rats with iron-induced hepatotoxicity

Farah Dheyaa Ahmed Haddad, Hind Bahjat Mohammed Aldik, Aseel Ibrahim Suhail

Abstract


Background: Hepatotoxicity is liver damage due to exposure to a toxic substance such as medications, alcohol, or certain chemicals. Iron induced hepatotoxicity may occur if the supplement is taken in excess or for an extended period.

Methods: This study aimed to synthesize a series of flavone derivatives and estimate their roles as protective agents against iron-induced hepatotoxicity. Confirmation of the structure of the synthesized chalcone and flavone products was obtained through the use of FTIR spectroscopy as well as other physicochemical properties.

Results: Excellent yields of chalcone derivatives were obtained through Aldol condensation of 2-hydroxyacetophenone and 2,4-dihydroxybenzaldehyde using SOCl2/ETOH as a catalyst. In contrast, oxidative cyclization of the synthesized 2'-chalcone derivative in dimethyl sulfoxide (DMSO) with iodine affords the corresponding flavone derivatives.

Conclusion: The novel flavone compound exhibited a substantially efficient capability in hepatoprotection against iron overload, and we found that it exhibited antioxidant activity.

Keywords: Chalcone derivative, Flavone derivative, Ferrous sulfate, Hepatotoxicity

Editorial Note on Version of Record
03 Oct 2026: This article has been corrected. See https://doi.org/10.62940/als.v13i0.4362 for more information.


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DOI: https://doi.org/10.62940/als.v12i3.2263

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