Comparative Evaluation of Salivary LL-37 and TNF-α in Children with and without Dental Caries: A Case-Control Study

Sarah Jamal Kareem, Batool Al-Ghurabi

Abstract


Background: A major social, behavioral, and oral health issue is the prevalence of caries in children's teeth and gums at an early age. Caries arises from a bacterial infection due to several factors, including an unhealthy diet. Natural AMPs serve as a frontline defense against a broad variety of infections, while cytokines are biomarkers for a wide variety of disorders and also serve as essential agents in both immunological and inflammatory reactions. Many researchers have studied and reported the effects of LL-37 and TNF-α in Early Childhood Caries (ECC) among children.

Methods: Eighty kids between the ages of 4 and 5 took part in the research. 40 children were with caries and considered as the patient group, whereas the other children (40) were without caries of similar age and sex as the control subjects. Clinical caries experience is measured through a dental examination and the dmfs index. From all participants, samples were collected. Salivary LL-37 and TNF-α levels were analyzed by the ELISA.

Result: The present investigation demonstrated a substantial rise (P ˂ 0.01) in the values of LL-37 and TNF-α in caries children compared to children without caries.

Conclusion: The children with ECC were found to have an elevation in LL-37 and TNF-α. This indicated that decay associated with the elevating LL-37 and TNF-α levels.

Keywords: LL-37; TNF-α; Caries, Dental; Antimicrobial peptides (AMPs); Early Childhood Caries


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References


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DOI: http://dx.doi.org/10.62940/als.v12i4.2620

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