Correction: Androgen Receptor (AR) ablation encumbers the expansion and function of T regulatory cells (Treg) in a male mouse model

Abstract

This Correction refers to:

Altuwaijri S, Albarrak SM. (2025). Androgen Receptor (AR) ablation encumbers the expansion and function of T regulatory cells (Treg) in a male mouse model. Advancements in Life Sciences, 12(1): 197204.
https://doi.org/10.62940/als.v12i1.3275

Following a post-publication editorial quality review, the Editorial Office identified several reference mismatches in the above article. The authors subsequently reviewed the cited literature and replaced the references that were not the most appropriate sources with references that more directly support the corresponding statements in the manuscript.

These corrections are limited to citation and reference updates and do not affect the experimental dataset, numerical results, tables, figures, statistical analyses, or the main conclusions of the study.

Reference and citation corrections

• References [2] and [3] The original citations were replaced with Klein et al. (2015) and Klein and Flanagan (2016), respectively. These references more appropriately support the statements regarding sex-based differences in immune responses, susceptibility to infectious diseases, and vaccine responses.
• Reference [5] The citation supporting the statement regarding sex and gender influences on cancer immunotherapy responses was replaced with Irelli et al. (2020), which directly addresses this topic.
• Reference [12] The citation supporting the statement regarding increased asthma risk among individuals with androgen receptor deficiency was replaced with Gaston et al. (2021).
• Reference [22] The citation supporting the methodology for T-cell proliferation assessment was replaced with Ganesan et al. (2023), which provides a more appropriate methodological reference for lymphocyte proliferation assays.
• Reference [24] The citation supporting the statement regarding the effects of sex hormones on thymic hypocellularity and Treg development was replaced with Taves and Ashwell (2022).
• Original Reference [38] The citation supporting the statement concerning impaired suppressive function associated with IL-10 deficiency in regulatory T cells was replaced with Ring et al. (2011). Following revision and renumbering of the reference list, this source appears as Reference [37] in the corrected manuscript.
• Original Reference [47] The citation supporting the statement regarding androgen receptor effects on thymopoiesis and T-cell homeostasis was corrected to Wilhelmson et al. (2020). This source was already included elsewhere in the reference list and, following revision and renumbering, appears as Reference [28] in the corrected manuscript.

Corrected references

Ref. [2]. Klein SL, Marriott I, Fish EN. Sex-based differences in immune function and responses to vaccination. Transactions of the Royal Society of Tropical Medicine and Hygiene. (2015);109(1):915.

Ref. [3]. Klein SL, Flanagan KL. Sex differences in immune responses. Nature Reviews Immunology. (2016);16(10):626638.

Ref. [5]. Irelli A, Sirufo MM, D'Ugo C, Ginaldi L, De Martinis M. Sex and Gender Influences on Cancer Immunotherapy Response. Biomedicines. (2020);8(7):232.

Ref. [12]. Gaston B, Marozkina N, Newcomb DC, Sharifi N, Zein J. Asthma Risk Among Individuals With Androgen Receptor Deficiency. JAMA Pediatrics. (2021);175(7):743745.

Ref. [22]. Ganesan N, Ronsmans S, Hoet P. Methods to Assess Proliferation of Stimulated Human Lymphocytes In Vitro: A Narrative Review. Cells. (2023);12(3):386.

Ref. [24]. Taves MD, Ashwell JD. Effects of sex steroids on thymic epithelium and thymocyte development. Frontiers in Immunology. (2022);13:975858.

Ref. [28]. Wilhelmson AS, Lantero Rodriguez M, Johansson I, Svedlund Eriksson E, Stubelius A, Lindgren S, et al. Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice. Frontiers in Immunology. (2020);11:1342.

Ref. [37]. Ring S, Enk AH, Mahnke K. Regulatory T Cells from IL-10-Deficient Mice Fail to Suppress Contact Hypersensitivity Reactions Due to Lack of Adenosine Production. Journal of Investigative Dermatology. (2011);131(7):14941502.

These corrections do not affect the study's data, results, or conclusions.

Correction Published

03 October 2026: The necessary corrections have been carried out in the Version of Record.