Dog Coat Colour Genetics: A Review

Rashid Saif, Ali Iftekhar, Fatima Asif, Mohammad Suliman Alghanem

Abstract


Canis lupus familiaris is one of the most beloved pet species with hundreds of world-wide recognized breeds, which can be differentiated from each other by specific morphological, behavioral and adoptive traits. Morphological characteristics of dog breeds get more attention which can be defined mostly by coat color and its texture, and considered to be incredibly lucrative traits in this valued species. Although the genetic foundation of coat color has been well stated in the literature, but still very little is known about the growth pattern, hair length and curly coat trait genes. Skin pigmentation is determined by eumelanin and pheomelanin switching phenomenon which is under the control of Melanocortin 1 Receptor and Agouti Signaling Protein genes. Genetic variations in the genes involved in pigmentation pathway provide basic understanding of melanocortin physiology and evolutionary adaptation of this trait. So in this review, we highlighted, gathered and comprehend the genetic mutations, associated and likely to be associated variants in the genes involved in the coat color and texture trait along with their phenotypes. Moreover, genetic diversity of other associated genes were also pointed out to understand this phenomena in detail along with their genotypes for better understanding the expression and mode of inheritance of this trait for describing dog breeds with more accuracy.

Keywords: Dog breeds; Dog color variants; Dog texture genetics; Dog breed differentiation  


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Hédan B, Corre S, Hitte C, Dréano S, Vilboux T, et al. Coat colour in dogs: identification of the merle locus in the Australian shepherd breed. (2006); 2(1): 9.

Ostrander EAJAS. Genetics and the Shape of Dogs: Studying the new sequence of the canine genome shows how tiny genetic changes can create enormous variation within a single species. (2007); 95(5): 406-413.

Kaelin CB, Barsh GSJTGotD. Colour, Texture and Length in the Dog. (2012); 57.

Bardeleben C, Moore RL, Wayne RKJMp, evolution. A molecular phylogeny of the Canidae based on six nuclear loci. (2005); 37(3): 815-831.

Lindblad-Toh K, Wade CM, Mikkelsen TS, Karlsson EK, Jaffe DB, et al. Genome sequence, comparative analysis and haplotype structure of the domestic dog. (2005); 438(7069): 803.

Savolainen P, Zhang Y-p, Luo J, Lundeberg J, Leitner TJS. Genetic evidence for an East Asian origin of domestic dogs. (2002); 298(5598): 1610-1613.

Wayne RK, Leonard JA, Vilà CJDdNg, paradigms a. Genetic analysis of dog domestication. (2006); 279-293.

Shearin AL, Ostrander EAJPb. Canine morphology: hunting for genes and tracking mutations. (2010); 8(3): e1000310.

Vaysse A, Ratnakumar A, Derrien T, Axelsson E, Pielberg GR, et al. Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. (2011); 7(10): e1002316.

Vilà C, Savolainen P, Maldonado JE, Amorim IR, Rice JE, et al. Multiple and ancient origins of the domestic dog. (1997); 276(5319): 1687-1689.

Minnick MF, Stillwell LC, Heineman JM, Stiegler GLJG. A highly repetitive DNA sequence possibly unique to canids. (1992); 110(2): 235-238.

Bauer A, Hadji Rasouliha S, Brunner M, Jagannathan V, Bucher I, et al. A second KRT 71 allele in curly coated dogs. (2019); 50(1): 97-100.

Salmela E, Niskanen J, Arumilli M, Donner J, Lohi H, et al. A novel KRT71 variant in curly‐coated dogs. (2019); 50(1): 101-104.

Parker HG, Harris A, Dreger DL, Davis BW, Ostrander EAJPTotRSBBS. The bald and the beautiful: hairlessness in domestic dog breeds. (2017); 372(1713): 20150488.

Parker HG, Whitaker DT, Harris AC, Ostrander EAJGG, Genomes, Genetics. Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a SGK3 Coding Variant Leads to Hairlessness. (2019).

Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, et al. Coat variation in the domestic dog is governed by variants in three genes. (2009); 326(5949): 150-153.

Parker HG, Chase K, Cadieu E, Lark KG, Ostrander EAJJoh. An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog. (2010); 101(5): 612-617.

Housley D, Venta PJAg. The long and the short of it: evidence that FGF5 is a major determinant of canine ‘hair’‐itability. (2006); 37(4): 309-315.

Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, et al. A mutation in hairless dogs implicates FOXI3 in ectodermal development. (2008); 321(5895): 1462-1462.

Dierks C, Mömke S, Philipp U, Distl OJAg. Allelic heterogeneity of FGF 5 mutations causes the long‐hair phenotype in dogs. (2013); 44(4): 425-431.

Hayward JJ, Castelhano MG, Oliveira KC, Corey E, Balkman C, et al. Complex disease and phenotype mapping in the domestic dog. (2016); 710460.

Buzhardt L. Genetics Basics – Coat Color Genetics in Dogs. (2016).

Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, et al. Genetic structure of the purebred domestic dog. (2004); 304(5674): 1160-1164.

Caduff M, Bauer A, Jagannathan V, Leeb TJPo. OCA2 splice site variant in German Spitz dogs with oculocutaneous albinism. (2017); 12(10): e0185944.

Berryere TG, Kerns JA, Barsh GS, Schmutz SMJMG. Association of an Agouti allele with fawn or sable coat color in domestic dogs. (2005); 16(4): 262-272.

Dreger DL, Schmutz SMJJoH. A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs. (2011); 102(Suppl_1): S11-S18.

Kerns JA, Newton J, Berryere TG, Rubin EM, Cheng J-F, et al. Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs. (2004); 15(10): 798-808.

Schmutz SM, Berryere TG, Barta JL, Reddick KD, Schmutz JKJJoh. Agouti sequence polymorphisms in coyotes, wolves and dogs suggest hybridization. (2007); 98(4): 351-355.

Schmutz S, Berryere TJAg. Genes affecting coat colour and pattern in domestic dogs: a review. (2007); 38(6): 539-549.

Bauer A, Kehl A, Jagannathan V, Leeb TJAg. A novel MLPH variant in dogs with coat colour dilution. (2018); 49(1): 94-97.

Schmutz S, Berryere T, Ellinwood N, Kerns J, Barsh GJJoH. MC1R studies in dogs with melanistic mask or brindle patterns. (2003); 94(1): 69-73.

Newton J, Wilkie AL, He L, Jordan SA, Metallinos DL, et al. Melanocortin 1 receptor variation in the domestic dog. (2000); 11(1): 24-30.

Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, et al. A β-defensin mutation causes black coat color in domestic dogs. (2007); 318(5855): 1418-1423.

Kerns JA, Cargill EJ, Clark LA, Candille SI, Berryere TG, et al. Linkage and segregation analysis of black and brindle coat color in domestic dogs. (2007); 176(3): 1679-1689.

Korec E, Hančl M, Bydžovská M, Chalupa O, Korcová JJBg. Inheritance of coat colour in the cane Corso Italiano dog. (2019); 20(1): 24.

Winkler PA, Gornik KR, Ramsey DT, Dubielzig RR, Venta PJ, et al. A partial gene deletion of SLC45A2 causes oculocutaneous albinism in Doberman pinscher dogs. (2014); 9(3): e92127.

Clark LA, Wahl JM, Rees CA, Murphy KEJPotNAoS. Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. (2006); 103(5): 1376-1381.

Clark LA, Starr AN, Tsai KL, Murphy KEJG. Genome-wide linkage scan localizes the harlequin locus in the Great Dane to chromosome 9. (2008); 418(1-2): 49-52.

Clark LA, Tsai KL, Starr AN, Nowend KL, Murphy KEJG. A missense mutation in the 20S proteasome β2 subunit of Great Danes having harlequin coat patterning. (2011); 97(4): 244-248.

Schmutz SM, Berryere TG, Dreger DLJJoH. MITF and white spotting in dogs: a population study. (2009); 100(suppl_1): S66-S74.


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