Potent Implications of miRNA in Cancer Biology – A Brief Review

Zeeshan Javed, Muhammad Zaheer Iqbal, Muhammad Umair Latif, Hafiz Muhammad Farooq Yaqub, Qamar Raza Qadri


Groundbreaking findings through high-throughput technologies have deepened our understanding on an intricate interplay between products of coding sequences and noncoding RNAs. Increasingly it is being realized that miRNA, produced from what was previously considered as "genomic trash" have revolutionized the field of molecular and translational oncology. Overwhelmingly accumulating in-vitro and in-vivo studies have demonstrated that miRNA are key players involved in post-transcriptional regulation of gene network in numerous human pathologies including cancer. In this review we have attempted to provide recent advancements related to multifaceted roles played by miRNA in modulation of oncogenes and tumor suppressor genes.

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