Experimental Use of the Triazavirin Antiviral Medication in Conditions of Group Administration at the Pig-Breeding Unit

Tatiana Ivanovna Reshetnikova, Alexander Sergeyevich Zenkin, Tatyana Georgievna Krylova

Abstract


Background: The spread of viral and microbial agents is active in Pig-breeding units. Due to illness, animals lose their productivity, which can affect the economy of the enterprise. The purpose of our experiment was to conduct an experimental study of the use of the Triazavirin antiviral medication on piglets in conditions of group administration at the pig-breeding unit and to assess the long-term effects of administering the medication.

Methods: The experiment involved 30 heads of piglets. Upon admission, groups were formed taking into account the condition and age of the animals. Piglets with lesions of the respiratory system and with obvious clinical signs were selected for the experiment. In the first experimental group, experimental piglets received the Triazavirin antiviral medication. In the 2nd (control) group, the experimental animals were not subject to any treatment. In the 3rd experimental group, Tylosin-50 antibacterial medication was used for the treatment of animals. During the experiment, clinical studies and blood tests (biochemical, immunological, hormonal tests) were carried out.

Result: When piglets were given the Triazavirin medication, they demonstrated a stable average daily weight gain and the highest percentage of meat yield. When analyzing the biochemical parameters of animals in the first experimental group, stabilization of several indicators was noted (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, iron, total iron-binding capacity, transferrin saturation coefficient). In the case of Triazavirin administration, there was an increase in the level of free thyroxine and triiodothyronine, a decrease in thyroid-stimulating hormone, and cortisol.

Conclusion: Based on the results of clinical studies, the authors recommend using the Triazavirin medication as part of complex and etiological therapy in the treatment of the respiratory system of pigs affected with diseases of a viral nature.

Keywords: Piglets; Antiviral medication; Average daily growth; Blood test Lipoprotein; Tuberculosis


Full Text:

PDF

References


Belkin BL, Malakhova NA, Komarov VYu, Urazaev DN, Prudnikov VS. Obshchie podkhody k lecheniyu molodnyaka svinei pri boleznyakh, protekayushchikh s diareinym i respiratornym sindromom [General approaches to the treatment of young pigs with diseases associated with the diarrheal and respiratory syndrome]. Vestnik agrarnoi nauki, (2018); 3(72): 87-91.

Leonteva IV, Marinicheva MP, Appolonova DN. Effektivnost primeneniya preparatov Lozeval i DAFS-25 v novoi lekarstvennoi forme pri vyrashchivanii molodnyaka svinei [The effectiveness of the use of Lozeval and DAFS-25 medications in a new dosage form for growing young pigs]. Territoriya innovatsii, (2016); 2: 103-107.

Reshetnikova TI. Izuchenie khronicheskoi toksichnosti protivovirusnogo preparata Triazavirin [Study of the chronic toxicity of the Triazavirin antiviral medication]. Veterinariya, (2019); 1: 49–51.

Golovko VA, Severin RV, Malakei OA. Struktura assotsiirovannykh infektsii svinei s proyavleniem respiratornoi patologii v fermerskikh khozyaistvakh kharkovskoi oblasti [Structure of associated infections in pigs with manifestation of respiratory pathology in the farms of the Kharkiv region]: Razrabotka innovatsionnykh tekhnologii proizvodstva zhivotnovodcheskogo syrya i produktov pitaniya na osnove sovremennykh biotekhnologicheskikh metodov Materialy Mezhdunarodnoi nauchno-prakticheskoi konferentsii [Development of innovative technologies for the production of livestock raw materials and food products based on modern biotechnological methods Materials of the International research and practice conference]. 2016; 175-186. OOO “SFERA”.

Maksimovich VV, Semenov VM, Gaisenok SL, Kashpar LN. "Svinoi" gripp v god svini - eto serezno! [Swine flu during the Year of the Pig is a serious thing]. Nashe selskoe khozyaistvo, (2019); 12(212): 74-77.

Reshetnikova TI, Zenkin AS. Eksperimenalnoe primenenie protivovirusnogo preparata Triazavirin na porosyatakh s simptomami porazheniya dykhatelnoi sistemy [Experimental use of the Triazavirin antiviral medication on piglets with symptoms of respiratory system damage]. Ippologiya i veterinariya, (2020); 4(38): 123–131.

Reshetnikova TI, Zenkin AS, Stolyarov VA, Rodina EV, Rodin VN. Studying the Safety of the Antiviral Preparation Triazavirin. International Journal on Emerging Technologies, (2020); 11(2): 99-103.

Reshetnikova TI, Zenkin AS, Krylova TG. The Histological Structure of Pig Organs and Tissues during the Experimental Use of the Triazavirin Antiviral Drug. Journal of Biochemical Technology, (2020); 11(4): 1-7.

Gladkikh LP, Nikitin DA, Semenov VG. Novye otechestvennye biopreparaty v profilaktike zabolevanii porosyat [New Russian biological preparations in the prevention of diseases of piglets]: Nauchno-obrazovatelnaya sreda kak osnova razvitiya agropromyshlennogo kompleksa i sotsialnoi infrastruktury sela materialy mezhdunarodnoi nauchno-prakticheskoi konferentsii (posvyashchennoi 85-letiyu FGBOU VO Chuvashskaya GSKhA) [Scientific and educational environment as the basis for the development of the agro-industrial complex and social infrastructure of the village. Materials of the international research and practice conference (dedicated to the 85th anniversary of the FSBEI HE Chuvash State Agricultural Academy)]. 2016; 276-279. FGBOU VO Chuvashskaya gosudarstvennaya selskokhozyaistvennaya akademiya [Federal State Budget-Funded Institution of Higher Education Chuvash State Agricultural Academy].

Filatov AV, Sapozhnikov AF, Shemuranova NA. Morfologicheskii i immunobiokhimicheskii sostav krovi u svinei na otkorme pri primenenii kormovoi dobavki VERVA [Morphological and immunobiochemical composition of blood in fattening pigs with the use of the VERVA feed supplement]. Agrarnoe obrazovanie i nauka, (2016); 1: 14.

Reshetnikova TI, Zenkin AS. Comparative Analysis of the Chronic Toxicity of the Ingavirin, Rimantadine, Triazavirin, and Moxifloxacin Drugs. Revista Inclusiones, (2020); 7(Especial): 32-39.

Preobrazhenskii GD, Shemanaev SV. Skrytyi rezerv zdorovya i produktivnosti porosyat [Hidden reserves of piglets' health and productivity]. Svinovodstvo, (2019); 4: 63-64.

Reshetnikova TI. Opredelenie ostroi toksichnosti protivovirusnogo preparata Triazavirin [Determination of acute toxicity of the Triazavirin antiviral medication]. Veterinarnyi vrach, (2018); 5: 42–48.

Reshetnikova TI. Morfologicheskie i biokhimicheskie pokazateli krovi laboratornykh zhivotnykh pri eksperimentalnom primenenii novogo protivovirusnogo preparata [Morphological and biochemical parameters of the blood of laboratory animals during the experimental use of a new antiviral medication]. Voprosy normativno-pravovogo regulirovaniya v veterinarii, (2018); 4: 151–155.

Council of Europe. European Treaty Series - No. 123. European Convention for the Protection of Vertebrate Animals for Experimental and Other Scientific Purposes. March 18, 1986; 51 p. Strasbourg.


Refbacks

  • There are currently no refbacks.