The correlation between atrophic gastritis and Helicobacter pylori infection in patients referred to Shohadaye Ashayer Hospital in Khorramabad

Ghobad Abangah, Ahmed Hjazi, Rana Sherdil Amin, Ghadeer Sabah Bustani, Rosario Mireya Romero-Parra, Rahman S. Zabibah, Mosayeb Moradniani, Mahsa Yousefpour Marzbali, Mohamad Reza Nazer, Masoumeh Tahmasebi

Abstract


Background: Helicobacter pylori and atrophic gastritis are both known as risk factors for gastric cancer. The purpose of this study is to investigate the prevalence of Helicobacter pylori infection in patients with atrophic gastritis. In addition to being aware of the prevalence of this infection, it is crucial to eliminated of this bacterium due to its carcinogenicity.

Methods: In this descriptive-cross-sectional study, all patients referred to the endoscopy unit of Shohadaye Ashayer Hospital in Khorramabad city for endoscopy during 2015–2016 were included. Referees with atrophic gastritis were classified as patients, while those without the condition were classified as the control group. Then, the frequency of H. pylori infection in patients with atrophic gastritis and people without atrophic gastritis was investigated. After sample collection, the primary data was entered into the SPSS software version 22 for analysis.

Result: The collected results showed that 2121 patients (41%) did not have H. pylori and 3053 patients (59%) had H. pylori. The population over 50 years old had the highest age frequency in the study subjects, while the female group had the highest gender frequency. As a result, the frequency of H. pylori in the antrum area was higher than in other locations in both endoscopy and pathology, but it was not statistically significant (P value >0.05). 54.1% of those who had endoscopy-discovered atrophy also had severe atrophy. H. pylori was found in the antrum in 50% of cases, and in 61.1% of cases when the pathology showed atrophy. This finding was statistically significant (P value <0.05).The incidence of reporting atrophy was 2.8 times higher in the age group of over 50 compared to those under 20. H. pylori was detected in 56.4% of people over 50 who had atrophy; that was statistically significant.

Conclusion: According to the results, there is a significant risk of developing atrophic gastritis in patients with H. pylori, and among females, those over 50 years old have the highest frequency of occurrence.


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References


Ilic M, Ilic I. Epidemiology of stomach cancer. World Journal of Gastroenterology, (2022); 28(12):1187.

Chophel T, Tshering S, Dorji N, Tshomo U. Stomach cancer screening services of Bhutan. Indian Journal of Surgery, (2022); 23:1-6.

Manouchehri N, Ghodsi S, Atri F, Sarraf P, Seyedi D, Valizadeh S. Effect of pretreatment of root dentin surface with cold atmospheric plasma on improving the bond strength of fiber post and resin cement: In vitro study. Clinical and Experimental Dental Research, (2023); 9(4): 653-660.

Mohammed ZJ, Rasool KH, Ahmed MA. Relationship between Helicobacter pylori infections and vitamin D level and lipid profile in some obese Iraqi women. Caspian Journal of Environmental Sciences, (2021); 19(5): 801-807.

Tokunaga M, Yoshikawa T, Boku N, Nishida Y, Tanahashi T, Yamada T, Haruta S, Etoh T, Hirahara N, Kawachi Y, Tsuji K. Impact of COVID-19 on gastric cancer treatment in Japanese high-volume centers: a JCOG stomach cancer study group survey. Surgery today, (2022); 52(2): 231-8.

Suh M, Wikoff D, Lipworth L, Goodman M, Fitch S, Mittal L, Ring C, Proctor D. Hexavalent chromium and stomach cancer: a systematic review and meta-analysis. Critical Reviews in Toxicology, (2019); 49(2): 140-59.

Yang L, Zheng R, Wang N, Yuan Y, Liu S, Li H, Zhang S, Zeng H, Chen W. Incidence and mortality of stomach cancer in China, 2014. Chinese Journal of Cancer Research, (2018); 30(3): 291.

Nadeem H, Nawaz A, Nawaz A, Shams K, Mubarak B. Frequency of Helicobacter pylori Infections and Its Associated Risk Factors in Patients Attending Tertiary Care Hospital of Bhakkar, Pakistan. Advancements in Life Sciences, (2022); 9(3): 323-7.

Shah SC, Piazuelo MB, Kuipers EJ, Li D. AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review. Gastroenterology, (2021); 161(4): 1325-32.

Ghobadi E, Ghanbarimasir Z, Emami S. A review on the structures and biological activities of anti-Helicobacter pylori agents. European Journal of Medicinal Chemistry, (202); 223: 113669.

Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T, et al. Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development. World Journal of Gastroenterology: WJG, (2014); 20(18): 5461.

Lan HC, Chen TS, Li AFY, Chang FY, Lin HC. Additional corpus biopsy enhances the detection of Helicobacter pylori infection in a background of gastritis with atrophy. BMC gastroenterology, (2012); 12(1): 1.

Öztekin M, Yılmaz B, Ağagündüz D, Capasso R. Overview of Helicobacter pylori Infection: Clinical Features, treatment, and nutritional aspects. Diseases, (2021); 9(4): 66.

Charitos IA, D’Agostino D, Topi S, Bottalico L. 40 Years of Helicobacter pylori: a revolution in biomedical thought. Gastroenterology Insights, (2022); 12(2): 111-35.

Siao D, Somsouk M. Helicobacter pylori: evidence-based review with a focus on immigrant populations. Journal of general internal medicine, (2014); 29(3): 520-8.

Tshibangu-Kabamba E, Yamaoka Y. Helicobacter pylori infection and antibiotic resistance—from biology to clinical implications. Nature Reviews Gastroenterology & Hepatology, (2021); 18(9): 613-29.

Moayyedi P, Wason C, Peacock R, Walan A, Bardhan K, Axon AT, et al. Changing patterns of Helicobacter pylori gastritis in long‐standing acid suppression. Helicobacter, (2000); 5(4): 206-14.

Pan KF, Zhang L, Gerhard M, Ma JL, Liu WD, Ulm K, et al. A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication. Gut, (2016); 65(1): 9-18.

Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology, (2007); 133(2): 659.

Chen S, Ying L, Kong M, Zhang Y, Li Y. The prevalence of Helicobacter pylori infection decreases with older age in atrophic gastritis. Gastroenterology research and practice, (2013).494783 ;

Darnindro N, Syam AF, Handjari DR, Makmun D. Gastric Mucous Atrophy and Metaplasia in Patient with Helicobacter pylori Infection. The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, (2015); 1(1): 13-6.

Guindy A, Ghoraba H. A study of the Concordance between endoscopic gastritis and histological gastritis in nonulcer dyspeptic patients with and without Helicobacter pylori infection. Tanta Medical Sciences Journal, (2007); 2(2): 67-82.

Myint T, Shiota S, Vilaichone RK, Ni N, Aye TT, Matsuda M, et al. Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar. World Journal of Gastroenterology, (2015); 21(2): 620-7.

Leja M, Cine E, Rudzite D, Vilkoite I, Huttunen T, Daugule I, et al. Prevalence of Helicobacter pylori infection and atrophic gastritis in Latvia. European journal of gastroenterology & hepatology, (2012); 24(12): 1410-7.

Mandil O, Sabri H, Manouchehri N, Mostafa D, Wang HL. Root coverage with apical tunnel approach using propolis as a root conditioning agent: A case report with 2‐year follow‐up and review of the literature. Clinical and Experimental Dental Research, (2023); 9(4): 568-573.

Baniesmaeeili SY, Akbarzadeh A, Riazi G, Abdollahi F, Niromand M. Effects of dietary Moringa oleifera leaf powder and ethanolic extract on expression function of immune genes of Litopenaeus vannamei. Aquatic Animals Nutrition, (2023); 9(1): 27-41.

Salimi K, Atri F, Valizadeh S, Sahebi M, Ghodsi S, Manouchehri N. Influence of nonthermal argon plasma on the micro-shear bond strength between resin cement and translucent zirconia. Journal of Conservative Dentistry, (2023); 26(3): 281.

Manouchehri N. Most Important Medicinal Plants with Anti-Halitosis Property: an Overview. Journal of Biochemicals and Phytomedicine, (2023); 2(1):1-2.

Kakeshian S, Shirali S, Savari A, Najafzadehvarzi H, Zakeri M. Alterations in histological structure, blood estrogen and progesterone levels after oral administration of garlic extract in yellowfin seabream (Acanthopagrus latus). Aquatic Animals Nutrition, (2022); 8(2): 1-10.

Manouchehri N. A Review of the Most Widely Used Medicinal Plants in the Treatment of Dental and Oral Disorders and Diseases, (2022); 1(1): 3–7.


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