The correlation between atrophic gastritis and Helicobacter pylori infection in patients referred to Shohadaye Ashayer Hospital in Khorramabad

Ghobad Abangah, Ahmed Hjazi, Rana Sherdil Amin, Ghadeer Sabah Bustani, Rosario Mireya Romero-Parra, Rahman S. Zabibah, Mosayeb Moradniani, Mahsa Yousefpour Marzbali, Mohamad Reza Nazer, Masoumeh Tahmasebi


Background: Helicobacter pylori and atrophic gastritis are both known as risk factors for gastric cancer. The purpose of this study is to investigate the prevalence of Helicobacter pylori infection in patients with atrophic gastritis. In addition to being aware of the prevalence of this infection, it is crucial to eliminated of this bacterium due to its carcinogenicity.

Methods: In this descriptive-cross-sectional study, all patients referred to the endoscopy unit of Shohadaye Ashayer Hospital in Khorramabad city for endoscopy during 2015–2016 were included. Referees with atrophic gastritis were classified as patients, while those without the condition were classified as the control group. Then, the frequency of H. pylori infection in patients with atrophic gastritis and people without atrophic gastritis was investigated. After sample collection, the primary data was entered into the SPSS software version 22 for analysis.

Result: The collected results showed that 2121 patients (41%) did not have H. pylori and 3053 patients (59%) had H. pylori. The population over 50 years old had the highest age frequency in the study subjects, while the female group had the highest gender frequency. As a result, the frequency of H. pylori in the antrum area was higher than in other locations in both endoscopy and pathology, but it was not statistically significant (P value >0.05). 54.1% of those who had endoscopy-discovered atrophy also had severe atrophy. H. pylori was found in the antrum in 50% of cases, and in 61.1% of cases when the pathology showed atrophy. This finding was statistically significant (P value <0.05).The incidence of reporting atrophy was 2.8 times higher in the age group of over 50 compared to those under 20. H. pylori was detected in 56.4% of people over 50 who had atrophy; that was statistically significant.

Conclusion: According to the results, there is a significant risk of developing atrophic gastritis in patients with H. pylori, and among females, those over 50 years old have the highest frequency of occurrence.

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