Possible correlations between SH2B3 rs2078863 gene polymorphism, lifestyle, food habits and nutritional intake of Minangkabau females with hypertension

Dita Hasni, Cimi Ilmiawati, Firdawati Firdawati, Nur Indrawaty Lipoeto

Abstract


Background: Hypertension is the commonest cardiovascular risk factor and a leading cause of death worldwide.  Several genetic variants are known to be involved in the pathogenesis of this disease. this study aimed to determine the relationship between the SH2B3 rs2078863 gene variants and hypertension in Minangkabau women.

Methods: In total, 190 women aged 18-45 years old participated in this study. Patient data, including weight, height, Body Mass Index (BMI), and blood pressure examinations, were collected, and interviews regarding their nutrient intake and physical activity were assessed with the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) and the Global Physical Activity Questionnaire (GPAQ) questionnaires. Blood was collected from peripheral veins, followed by DNA isolation and genotyping examination using the Kompetitive Allele Specific PCR (KASP) method.

Results: TT genotype in SH2B3 rs2078863 was observed to be more at risk of suffering from hypertension compared to the CC+CT genotype ((ꭓ2 (1, n=190)=8.442 p=.004, phi=.21, OR=2.48). The regression logistic analysis revealed the role of obesity, low physical activity, and age as risk factors for hypertension in the studied population (p<0.05).

Conclusion: In conclusion, the SH2B3 gene variant and lifestyle factors related to obesity, and low physical activity, increase the risk of hypertension.


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References


Arshad MI, Syed FJ. Essential hypertension, (2019). NCBI Bookshelf.

Banegas JR, Gijón-Conde T. Epidemiology of hypertension. Hipertension y Riesgo Vascular, (2017); 34: 2–4.

Ministry of Health Republic of Indonesia Main Results of Indonesian Basic Health Research 2018; Jakarta, (2018).

Padang HO. Padang city health profile in 2017, (2017). Padang.

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, De Ferranti SD, Floyd J, Fornage M, Gillespie C. Heart disease and stroke statistics’2017 update: A report from the American Heart

Association, (2017). Circulation.

Abramson BL, Melvin RG. Cardiovascular risk in women: Focus on hypertension. Canadian Journal Cardiology, (2014); 30: 553–559.

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, Ferranti S, De Després JP, Fullerton HJ. Heart disease and stroke statistics-2016 update a report from the American Heart Association, (2016); 133: 38–48.

Grillo A, Salvi L, Coruzzi P, Salvi P, Gianfranco P. Sodium intake and hypertension. Nutrients, (2019); 11(9):1970.

Dun Q, Xu W, Fu M, Wu N, Moore JB, Yu T, Li X, Du Y, Zhang B, Wang Q, Duan Y, Meng Z, Tian S, Zou Y. Physical activity, obesity, and hypertension among adults in a rapidly urbanised city. International Journal of Hypertension, (2021) Article ID 9982562.

Wang Q, Song X, Du S, Du W, Su C, Zhang J, Zhang X, Zhang B, Wang H. Waist circumference trajectories in relation to blood pressure and the risk of hypertension in chinese adults. Nutrients, (2022); 14: 5260.

Welch E. Hypertension. Nurs Stand, (2003); 13: 45-53.

Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertension Research, (2012); 35(11): 1039–1047.

Grillo A, Salvi L, Coruzzi P, Salvi P, Parati G. Sodium Intake and Hypertension. Nutrients, (2019); 11(9): 1970.

Adrogue HJ, Madias NE. Sodium and potasium in pathogenesis of hypertension. New England Journal of Medicine, (2007); 356(19): 1966-1978.

Hall JE, Mouton AJ, Da Silva AA, Omoto ACM, Wang Z, Li X, Do Carmo JM. Obesity, kidney dysfunction, and inflammation: interactions in hypertension. Cardiovascular Research, (2021); 117(8): 1859–1876.

Landsberg L, Aronne LJ, Beilin LJ, Burke V, Igel LI, Lloyd-Jones D, Sowers J. Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment a position paper of The Obesity Society and the American Society of Hypertension. journal of Clinical Hypertension, (2013); 15(1): 14–33.

Fardin NM, Oyama LM, Campos RR. Changes in baroreflex control of renal sympathetic nerve activity in high-fat-fed rats as a predictor of hypertension. Obesity, (2012); 20(8): 1591–1597.

Rahmouni K. Obesity-associated hypertension: recent progress in deciphering the pathogenesis. Hypertension, (2014); 64(2): 215–221.

Castro-Torres Y, Katholi RE. Natriuretic peptides, obesity and cardiovascular diseases. Revista da Associação Médica Brasileira, (2015); 61(1): 19-20.

DeMarco VG, Aroor AR, Sowers JR. The pathophysiology of hypertension in patients with obesity. Nature Reviews Endocrinology, (2014); 10(6): 364–376.

Te Riet L, Van Esch JHM, Roks AJM, Van Den Meiracker AH, Danser AHJ. Hypertension: renin-angiotensin-aldosterone system alterations. Circulation Research, (2015); 116(6): 960–975.

Padmanabhan S, Caulfield M, Dominiczak AF. Genetic and molecular aspects of hypertension. Circulation Research, (2015); 116 (6): 937–959.

Kunes J, Zicha J. The interaction of genetic and environmental factors in the etiology of hypertension. Physiology Research, (2009); 2: 33–41.

Stark A. The matrilineal system of the minangkabau and its persistence throughout History: a structural perspective. Southeast Asia A Multidisciplinary Journal, (2013); 13: 1–13.

Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cífková R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A, Whelton PK. Hypertension. Nature Reviews Disease Primers, (2018); 4: 18014.

Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T. Genome-wide association study of blood pressure and hypertension. National Genetic, (2009); 41(6): 677–687.

Ji Y, Song Y, Wang Q, Xu P, Zhao Z, Li X, Wang N, Jin T, Chen C. Sex-specific association of SH2B3 and SMARCA4 polymorphisms with coronary artery disease susceptibility. Oncotarget, (2017); 8(35): 59397–59407.

Nikitin AG, Lavrikova EY, Seregin YA, Zilberman LI, Tzitlidze NM, Kuraeva TL, Peterkova VA, Dedov II, Nosikov VV. Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes. Molecular biology, (2010);44(2):228-232.

Dale BL, Madhur MS. Linking inflammation and hypertension via LNK/SH2B3. Current Opinion in Nephrology and Hypertension, (2016); 25(2): 87–93.

Rudemiller NP, Lund H, Priestley JRC, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL. Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates dahl salt-sensitive hypertension via inflammatory modulation. Hypertension, (2015); 65(5): 1111–1117.

Blass G, Mattson DL, Staruschenko A. The function of SH2B3 (LNK) in the kidney. American Journal of Physiology-Renal Physiology, (2016); 311(4): 682–685.

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ. Biological, clinical and population relevance of 95 loci for blood lipids. Nature, (2010); 466(7307): 707–713.

Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetic, (2009); 41(6): 703–707.

Ji Y, Song Y, Wang Q, X P, Zhao Z, Li X, Wang N, Jin T, Chen C. Sex-specific association of SH2B3 and SMARCA4 polymorphisms with coronary artery disease susceptibility. Oncotarget, (2017); 8(35): 59397–59407.

Dupont WD, Plummer WD. Power and sample size calculations. a review and computer program. Control Clinical Trials, (1990); 11(2): 116–128.

Pan WH, Yeh WT. How to define obesity? evidence-based multiple action points for public awareness, screening, and treatment: an extension of asian-pacific recommendations. Asia Pacific Journal of

Clinical Nutrition, (2008); 17(3): 370–374.

Flack JM, Adekola B. Blood pressure and the new ACC/AHA hypertension guidelines. Trends in Cardiovascular Medical, (2020); 30(3): 160–164.

Keating XD, Zhou K, Liu X, Hodges M, Liu J, Guan J, Phelps A, Castro-Piñero J. Reliability and concurrent validity of global physical activity questionnaire (GPAQ): a systematic review. International

Journal Environment Research Public Health, (2019); 16(21): 4128.

Mumu SJ, Ali L, Barnett A, Merom D. Validity of the global physical activity questionnaire (GPAQ) in bangladesh. BMC Public Health, (2017); 17(1): 650.

Lipoeto NI, Agus Z, Oenzil F, Wahlqvist ML, Wattanapenpaiboon N. Dietary intake and the risk of coronary heart disease among the coconut-consuming minangkabau in West Sumatra, Indonesia. Asia Pacific Journal of Clinical Nutrition, (2004); 13(4): 377–384.

Surendran S, Aji AS, Ariyasra U, Sari SR, Malik SG, Tasrif N, Yani FF, Lovegrove JA, Sudji IR, Lipoeto NI. Vimaleswaran KS. A nutrigenetic approach for investigating the relationship between vitamin B12 status and metabolic traits in Indonesian Women. Journal Diabetes Metabolism Disorder, (2019); 18(2): 389–399.

Alathari BE, Aji AS, Ariyasra U, Sari SR, Tasrif N, Yani FF, Sudji IR, Lovegrove JA, Lipoeto NI, Vimaleswaran KS. Interaction between vitamin D-related genetic risk score and carbohydrate intake on body fat composition: a study in southeast asian inangkabau women. Nutrients, (2021); 13(2): 326.

Sudha V, Radhika G, Sathya RM, Ganesan A, Mohan V. Reproducibility and validity of an interviewer-administered semi-quantitative food frequency questionnaire to assess dietary intake of urban adults in southern India. International Journal Food Science Nutrition, (2006); 57(7-8): 481–493.

KASP Assays, PCR-Based Genotyping. LGC Biosearch Technologies Available online: https://www.biosearchtech.com/products/pcr-reagents-kits-and-instruments/pcr-probes-and-assays/kasp-genotyping-assays (accessed on 21 January 2023).

Kleinbaum DG, Klein M. Survival Analysis a Self-Learning Text, (1996), Springer.

Kleinbaum DG, Dietz K, Gail M, Klein M, Klein M. Logistic Regression, (2002), Springer.

Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nature Reviews Nephrology, (2020); 16: 223–237.

Le Hir H, Nott A, Moore MJ. How introns influence and enhance eukaryotic gene expression. Trends Biochemical Science, (2003); 28: 215–220.

Mori T, Iwasaki Y, Seki Y, Iseki M, Katayama H, Yamamoto K, Takatsu K, Takaki S. Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ–Producing T cells. Journal of Immunology, (2014); 193:1728–1736.

Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA. Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. Journal of Clinical Investigation, (2015); 125: 1189–1202.

Keefe JA, Hwang SJ, Huan T, Mendelson M, Yao C, Courchesne P, Saleh MA. Madhur MS, Levy D. Evidence for a causal role of the SH2B3 -Β2M axis in blood pressure regulation: framingham heart study. Hypertension, (2019); 73: 497–503.

Sun XN, Li C, Liu Y, Du LJ, Zeng MR, Zheng XJ, Zhang WC, Liu Y, Zhu M, Kong D. T-Cell mineralocorticoid receptor controls blood pressure by regulating interferon-gamma. Circulation Research (2017); 120: 1584–1597.

Norlander AE, Madhur MS, Harrison DG. Correction: The immunology of hypertension. Journal of Experimental Medicine, (2018); 215: 719–719.

Hall JE, do Carmo JM, da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension. Circulation Research (2015); 116: 991–1006.

Putra TR. The effects of obesity in the blood pressure elevation. Journal Majority, (2015); 4: 3.

Hall JE, Do Carmo JM, Da Silva AA, Wang Z, Hall ME. Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circulation Research, (2015); 116: 991–1006.

Lu SC, Akanji AO. Leptin, obesity, and hypertension: a review of pathogenetic mechanisms. Metabolism Syndome Relative Disorder, (2020); 18: 399–405.

Usfar AA, Fahmida U. Do indonesians follow its dietary guidelines?-evidence related to food consumption, healthy lifestyle, and nutritional status within the period 2000-2010. Asia Pacific Journal of

Clinical Nutrition, (2011); 20: 484–494.

Ministry of Health Republic of Indonesia. The Indonesian Dietary Recommendation (AKG-Angka Kecukupan Gizi) Indonesia, (2019); 45.

Gurven M, Blackwell AD, Rodriguez DE, Stieglitz J, Kaplan H. Does blood pressure inevitably rise with age?: longitudinal evidence among forager-horticulturalists. Hypertension, (2012); 60: 25–33.

Sun Z. Aging, arterial stiffness, and hypertension. Hypertension, (2015); 65: 252–256.

Singh JN, Nguyen T, Dhamoon AS. Physiology, blood pressure, age related changes, (2019); StatPearls Publishing.

Buford TW. Hypertension and aging. Aging Research and Revew, (2016); 26: 96-111.

Stachenfeld NS. Hormonal changes during menopause and the impact on fluid regulation. Reproduction Science, (2014); 21: 555-561.

Shen L, Wang L, Hu Y, Liu T, Guo J, Shen Y, Zhang R, Miles T, Li C. Associations of the ages at menarche and menopause with blood pressure and hypertension among middle-aged and older chinese women: a cross-sectional analysis of the baseline data of the china health and retirement longitudinal study. Hypertension Research, (2019); 42: 730–738.

Knight JA. Review physical inactivity associated diseases and disorders. Annals of Clinical Laboratory Science, (2012); 42: 320–337.

Gambardella J, Morelli MB, Wang XJ, Santulli G. Pathophysiological mechanisms underlying the beneficial effects of physical activity in hypertension. Journal of Clinical Hypertension, (2020); 22: 291-295.

Shantanam S. Potassium: friend or foe. Physiology and Behavior, (2018); 176: 139–148.

Kim YK, Kim Y, Hwang MY, Shimokawa K, Won S, Kato N, Tabara Y, Yokota M, Han BG, Lee JH. Identification of a genetic variant at 2q12.1 associated with blood pressure in east-asians by genome-wide scan including gene-environment interactions. BMC Medical Genetic, (2014); 15: 1–8.

Aschard H. A perspective on interaction effects in genetic association studies. Genetic Epidemiology, (2016); 40: 678–688.




DOI: http://dx.doi.org/10.62940/als.v10i4.2268

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