Advances and Prospects of Carbon Nanotubes in Cancer Research: Drug Delivery, Therapeutics, and Diagnostics

Islam Hamad, Amani Harb, Shrouq Twal, Adi Arida, Amal Mayyas, Rula Amr, Nour Bustanji, Mona Al Olabi, Yasser Bustanji

Abstract


Background: Carbon nanotubes (CNTs) have gained significant attention in cancer therapy due to their unique physicochemical properties, including a high surface area-to-volume ratio, mechanical strength, and nanoscale interactions with biological systems. Their versatility has advanced drug delivery, photothermal therapy, and targeted cancer treatments. This study employs bibliometric analysis to examine global research on CNT applications in oncology.

Methods: A comprehensive Scopus search identified 1,221 English-language, peer-reviewed publications published between 2003 and 2024. Bibliometric indicators were analyzed using Biblioshiny and VOSviewer, generating visualization, thematic, and conceptual maps.

Results: Findings show that Chinese researchers lead in publication output, while the United States has the greatest scientific impact. Keyword mapping identified key research areas and emerging trends, including CNT-based drug delivery, tumor-targeting strategies, photothermal and photodynamic therapies, and biosensing applications.

Conclusion: This study provides a comprehensive bibliometric analysis of global research trends on CNT applications in oncology, highlighting key research areas, collaborations, and emerging directions.

Keywords: Carbon Nanotubes, Cancer Therapy, Drug Delivery. Photothermal Therapy, Nanomedicine, Tumor Targeting, Bibliometric Study


Full Text:

PDF

References


Qannita RA, Alalami AI, Harb AA, Aleidi SM, Taneera J, et al. Targeting hypoxia-inducible factor-1 (HIF-1) in cancer: emerging therapeutic strategies and pathway regulation. Pharmaceuticals, (2024); 17(2): 214.

Malima NM, Owonubi SJ, Shombe GB, Revaprasadu N. Synthesis of Magnetic Carbon Nanotubes and Their Composites: Handbook of Magnetic Hybrid Nanoalloys and their Nanocomposites. 2022; 233-272. Springer.

Rabba’a M, Abu-Zurayk R, Abu-Irmaileh B, Mallouh SA, Bustanji Y. In vitro studies on curcumin-loaded multiwalled carbon nanotubes antioxidant activities and cytotoxicity against Hep G-2 liver cancer cell lines. Journal of Applied Pharmaceutical Science, (2024); 14(6): 218-230.

Venkataraman A, Amadi EV, Chen Y, Papadopoulos C. Carbon nanotube assembly and integration for applications. Nanoscale Research Letters, (2019); 14: 1-47.

Simon J, Flahaut E, Golzio M. Overview of carbon nanotubes for biomedical applications. Materials, (2019); 12(4): 624.

Huang B. Carbon nanotubes and their polymeric composites: The applications in tissue engineering. Biomanufacturing Reviews, (2020); 5(1): 3.

Rathinavel S, Priyadharshini K, Panda D. A review on carbon nanotube: An overview of synthesis, properties, functionalization, characterization, and the application. Materials Science and Engineering: B, (2021); 268: 115095.

Shoukat R, Khan MI. Carbon nanotubes: A review on properties, synthesis methods and applications in micro and nanotechnology. Microsystem Technologies, (2021); 27(12): 4183-4197.

Yaghmur A, Hamad I. Microfluidic nanomaterial synthesis and in situ SAXS, WAXS, or SANS characterization: manipulation of size characteristics and online elucidation of dynamic structural transitions. Molecules, (2022); 27(14): 4602.

Son KH, Hong JH, Lee JW. Carbon nanotubes as cancer therapeutic carriers and mediators. International Journal of Nanomedicine, (2016); 11: 5163-5185.

Kurul F, Turkmen H, Cetin AE, Topkaya SN. Nanomedicine: How nanomaterials are transforming drug delivery, bio-imaging, and diagnosis. Next Nanotechnology, (2025); 7: 100129.

Rode A, Sharma S, Mishra DK. Carbon nanotubes: classification, method of preparation and pharmaceutical application. Current Drug Delivery, (2018); 15(5): 620-629.

Bustanji Y, Taneera J, Semreen MH, Abu-Gharbieh E, El-Huneidi W, et al. Gold nanoparticles and breast cancer: A bibliometric analysis of the current state of research and future directions. OpenNano, (2023); 12: 100168.

Kiran AR, Kumari GK, Krishnamurthy PT. Carbon nanotubes in drug delivery: Focus on anticancer therapies. Journal of Drug Delivery Science and Technology, (2020); 59: 101892.

Brindhadevi K, Garalleh HA, Alalawi A, Al-Sarayreh E, Pugazhendhi A. Carbon nanomaterials: Types, synthesis strategies and their application as drug delivery system for cancer therapy. Biochemical Engineering Journal, (2023); 192: 108828.

Makki MMA, Hashem ARH, Dhiyab AAK. Carbon Nanotubes for Thermal Therapy CNTs: Effect of Nanotube Structure and Doping on Photothermal Properties, Anticancer Efficacy of CNT-Enhanced PTT and Systemic Delivery and Biocompatibility of CNTs for PTT. Current Clinical and Medical Education, (2024); 2(8): 29-47.

Naief MF, Mohammed SN, Mayouf HJ, Mohammed AM. A review of the role of carbon nanotubes for cancer treatment based on photothermal and photodynamic therapy techniques. Journal of Organometallic Chemistry, (2023); 1006: 122819.

Alamelu S, Venkatesan KB, Shagirtha K, Srinivasan MK, Panneerselvam C, et al. Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery. Drugs and Drug Candidates, (2024); 3(4): 813-837.

Gao S, Xu B, Sun J, Zhang Z. Nanotechnological advances in cancer: Therapy a comprehensive review of carbon nanotube applications. Frontiers in Bioengineering and Biotechnology, (2024); 12: 1351787.

Singhai NJ, Maheshwari R, Ramteke S. CD44 receptor targeted ‘smart’multi-walled carbon nanotubes for synergistic therapy of triple-negative breast cancer. Colloid and Interface Science Communications, (2020); 35: 100235.

Thakur CK, Neupane R, Karthikeyan C, Ashby Jr CR, Babu RJ, et al. Lysinated multiwalled carbon nanotubes with carbohydrate ligands as an effective nanocarrier for targeted doxorubicin delivery to breast cancer cells. Molecules, (2022); 27(21): 7461.

Zare H, Ahmadi S, Ghasemi A, Ghanbari M, Rabiee N, et al. Carbon nanotubes: Smart drug/gene delivery carriers. International Journal of Nanomedicine, (2021); 16: 1681-1706.

de Almeida Barcelos K, Garg J, Soares DCF, de Barros ALB, Zhao Y, et al. Recent advances in the applications of CNT-based nanomaterials in pharmaceutical nanotechnology and biomedical engineering. Journal of Drug Delivery Science and Technology, (2023); 79: 104834.

Ezzati Nazhad Dolatabadi J, Omidi Y, Losic D. Carbon nanotubes as an advanced drug and gene delivery nanosystem. Current Nanoscience, (2011); 7(3): 297-314.

Dong X, Sun Z, Wang X, Zhu D, Liu L, et al. Simultaneous monitoring of the drug release and antitumor effect of a novel drug delivery system-MWCNTs/DOX/TC. Drug Delivery, (2017); 24(1): 143-151.

Tabatabaei Rezaei SJ, Hesami A, Khorramabadi H, Amani V, Malekzadeh AM, et al. Pt (II) complexes immobilized on polymer?modified magnetic carbon nanotubes as a new platinum drug delivery system. Applied Organometallic Chemistry, (2018); 32(7): e4401.

Yang T, Wu Z, Wang P, Mu T, Qin H, et al. A large-inner-diameter multi-walled carbon nanotube-based dual-drug delivery system with pH-sensitive release properties. Journal of Materials Science: Materials in Medicine, (2017); 28: 92.

Salave S, Rana D, Vitore J, Jain A. Functionalized Carbon Nanotubes for Cell Tracking: Functionalized Carbon Nanotubes for Biomedical Applications. 2023; 319-338. Elsevier.

Zhou Y, Vinothini K, Dou F, Jing Y, Chuturgoon AA, et al. Hyper-branched multifunctional carbon nanotubes carrier for targeted liver cancer therapy. Arabian Journal of Chemistry,

(2022); 15(3): 103649.

Suo X, Eldridge BN, Zhang H, Mao C, Min Y, et al. P-glycoprotein-targeted photothermal therapy of drug-resistant cancer cells using antibody-conjugated carbon nanotubes. ACS Applied Materials and Interfaces, (2018); 10(39): 33464-33473.

Thakur CK, Karthikeyan C, Ashby Jr CR, Neupane R, Singh V, et al. Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery. Frontiers in Pharmacology, (2024); 15: 1417399.

Fraczyk J, Walczak M, Szymanski L, Kolacinski Z, Wrzosek H, et al. Carbon nanotubes functionalized with folic acid attached via biomimetic peptide linker. Nanomedicine, (2017); 12(18): 2161-2182.

Ozgen PSO, Atasoy S, Kurt BZ, Durmus Z, Yigit G, et al. Glycopolymer decorated multiwalled carbon nanotubes for dual targeted breast cancer therapy. Journal of Materials Chemistry B, (2020); 8(15): 3123-3137.

Gharaibeh L, Alshaer W, Wehaibi S, Al Buqain R, Alqudah DA, et al. Fabrication of aptamer-guided siRNA loaded lipopolyplexes for gene silencing of notch 1 in MDA-mb-231 triple negative breast cancer cell line. Journal of Drug Delivery Science and Technology, (2021); 65: 102683.

Mostafavi E, Zare H. Carbon-based nanomaterials in gene therapy. OpenNano, (2022); 7: 100062.

Kwak S-Y, Lew TTS, Sweeney CJ, Koman VB, Wong MH, et al. Chloroplast-selective gene delivery and expression in planta using chitosan-complexed single-walled carbon nanotube carriers. Nature Nanotechnology, (2019); 14(5): 447-455.

Aiedeh KM, Taha MO, Al-Hiari Y, Bustanji Y, Alkhatib HS. Effect of ionic crosslinking on the drug release properties of chitosan diacetate matrices. Journal of Pharmaceutical Sciences, (2007); 96(1): 38-43.

Al-Zoubi N, AlKhatib HS, Bustanji Y, Aiedeh K, Malamataris S. Sustained-release of buspirone HCl by co spray-drying with aqueous polymeric dispersions. European Journal of Pharmaceutics and Biopharmaceutics, (2008); 69(2): 735-742.

Alkhatib HS, Hamed S, Mohammad MK, Bustanji Y, Alkhalidi B, et al. Effects of thermal curing conditions on drug release from polyvinyl acetate-polyvinyl pyrrolidone matrices. AAPS PharmSciTech, (2010); 11(1): 253-266.

AlKhatib HS, Taha MO, Aiedeh KM, Bustanji Y, Sweileh B. Synthesis and in vitro behavior of iron-crosslinked N-methyl and N-benzyl hydroxamated derivatives of alginic acid as controlled release carriers. European Polymer Journal, (2006); 42(10): 2464-2474.

Hamad I, Harb AA, Bustanji Y. Liposome-based drug delivery systems in cancer research: an analysis of global landscape efforts and achievements. Pharmaceutics, (2024); 16(3): 395.

Alshaer W, Zraikat M, Amer A, Nsairat H, Lafi Z, et al. Encapsulation of echinomycin in cyclodextrin inclusion complexes into liposomes:: In vitro anti-proliferative and anti-invasive activity in glioblastoma. RSC Advances, (2019); 9(53): 30976-30988.

Hajleh MNA, Alzweiri M, Bustanji YK, Al-Dujaili EAS. Biodegradable poly (Lactic-co-glycolic acid) microparticles controlled delivery system: A review. Jordan Journal of Pharmaceutical Sciences, (2020); 13(3): 317-335.

Khdair A, Hamad I, Alkhatib H, Bustanji Y, Mohammad M, et al. Modified-chitosan nanoparticles: Novel drug delivery systems improve oral bioavailability of doxorubicin. European Journal of Pharmaceutical Sciences, (2016); 93: 38-44.

Telfah M, Al-Akhras MA, Telfah A, Jum’h I, Ababneh R, et al. 19F- and 1H-NMR investigations of ofloxacin fluoroquinolone tethered with silver nanoparticles as synergistic antibiotic combinations. Journal of Molecular Structure, (2023); 1292: 136207.

Lafi Z, Alshaer W, Hatmal MM, Zihlif M, Alqudah DA, et al. Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells. RSC Advances, (2021); 11(47): 29164-29177.

Garriga R, Herrero-Continente T, Palos M, Cebolla VL, Osada J, et al. Toxicity of carbon nanomaterials and their potential application as drug delivery systems: in vitro studies in Caco-2 and MCF-7 cell lines. Nanomaterials, (2020); 10(8): 1617.

Gallego J, Tapia J, Vargas M, Santamaria A, Orozco J, et al. Synthesis of graphene-coated carbon nanotubes-supported metal nanoparticles as multifunctional hybrid materials. Carbon, (2017); 111: 393-401.

Pardo J, Peng Z, Leblanc RM. Cancer targeting and drug delivery using carbon-based quantum dots and nanotubes. Molecules, (2018); 23(2): 378.

Twal S, Jaber N, Al-Remawi M, Hamad I, Al-Akayleh F, et al. Dual stimuli-responsive polymeric nanoparticles combining soluplus and chitosan for enhanced breast cancer targeting. RSC Advances, (2024); 14(5): 3070-3084.

Hamad I, Aleidi SM, Alshaer W, Twal S, Al Olabi M, et al. Advancements and global perspectives in the green synthesis of silver nanoparticles: A two-decade analysis. Pharmacia, (2025); 72: 1-13.

Aleidi SM, Harb AA, Dahabiyeh LA, Al-Iede M, Hamad I, et al. Research Trend in The Inhibition of Transient Receptor Potential Vanilloid 1 (TRPV1): Bibliometric Analysis and Visualization. Journal of Applied Pharmaceutical Science, (2024); 14(11): 153-166.

Bustanji Y, Shihab KHA, El-Huneidi W, Semreen MH, Abu-Gharbieh E, et al. Analysis and mapping of global scientific research on human monkeypox over the past 20 years. Veterinary World, (2023); 16(4): 693-703.

Bustanji Y, Taneera J, Bargooth A, Abuhelwa A, Issa A, et al. Exploring the global landscape of self-medication among students: Trends, risks, and recommendations for safe and responsible practices. Pharmacy Practice, (2024); 22(1): 2869.

Bustanji Y, Al-Omari L, Taneera J, Aleidi SM, Abuhelwa AY, et al. Mapping non-coding RNAs (ncRNAs) in cancer research: Bibliometric trends, emerging themes, and implications for diagnostics and therapy. Advancements in Life Sciences, (2026); 13(1): 4001.

Aria M. bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of Informetrics, (2017); 11(4): 959–975.

Moral-Munoz J, Herrera-Viedma E, Espejo A, Cobo M. Software tools for conducting bibliometric analysis in science: An up-to-date review. El Profesional de la Información, (2020); 29(1): e290103.

van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, (2010); 84(2): 523-538.

Mousavi SM, Nezhad FF, Ghahramani Y, Binazadeh M, Javidi Z, et al. Recent Advances in Bioactive Carbon Nanotubes Based on Polymer Composites for Biosensor Applications. Chemistry and Biodiversity, (2024); 21(7): e202400231.

Sobh RA, Nasr HES, Mohamed WS. Formulation and in vitro characterization of anticancer drugs encapsulated chitosan/multi-walled carbon nanotube nanocomposites. Journal of Applied Pharmaceutical Science, (2019); 9(8): 32-40.

Zygouri P, Athinodorou AM, Spyrou K, Simos YV, Subrati M, et al. Oxidized-multiwalled carbon nanotubes as non-toxic nanocarriers for hydroxytyrosol delivery in cells. Nanomaterials, (2023); 13(4): 692.

Shabnum SS, Siranjeevi R, Raj CK, Nivetha P, Benazir K. A Comprehensive Review on Recent Progress in Carbon Nanotubes for Biomedical Application. Environmental Quality Management, (2025); 34(3): e70040.

Badea N, Craciun MM, Dragomir AS, Balas M, Dinischiotu A, et al. Systems based on carbon nanotubes with potential in cancer therapy. Materials Chemistry and Physics, (2020); 241: 122435.

Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WAH, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nature Nanotechnology, (2008); 3(7): 423-428.

Dizaji BF, Khoshbakht S, Farboudi A, Azarbaijan MH, Irani M. Far-reaching advances in the role of carbon nanotubes in cancer therapy. Life Sciences, (2020); 257: 118059.

Murjani BO, Kadu PS, Bansod M, Vaidya SS, Yadav MD. Carbon nanotubes in biomedical applications: current status, promises, and challenges. Carbon Letters, (2022); 32(5): 1207-1226.

Ahmad I, Parween T, Khandare L, Tantray A, Siddiqi WA. Applications of Functionalized Carbon Nanotubes in Cancer Therapy and Diagnosis: Functionalized Carbon Nanotubes for Biomedical Applications. 2023; 171-196. Elsevier.

Siddique S, Chow JC. Application of nanomaterials in biomedical imaging and cancer therapy. Nanomaterials, (2020); 10(9): 1700.

Babele PK, Verma MK, Bhatia RK. Carbon nanotubes: A review on risks assessment, mechanism of toxicity and future directives to prevent health implication. Biocell, (2021); 45(2): 267.

Ravelli D, Merli D, Quartarone E, Profumo A, Mustarelli P, et al. PEGylated carbon nanotubes: preparation, properties and applications. RSC Advances, (2013); 3(33): 13569-13582.

Habibizadeh M, Rostamizadeh K, Dalali N, Ramazani A. Preparation and characterization of PEGylated multiwall carbon nanotubes as covalently conjugated and non-covalent drug carrier: A comparative study. Materials Science and Engineering: C, (2017); 74: 1-9.

Awasthi S, Srivastava A, Kumar D, Pandey SK, Mubarak NM, et al. An insight into the toxicological impacts of carbon nanotubes (CNTs) on human health: A review. Environmental Advances, (2024); 15: 100601.

Kumar P, Pandey SN, Ahmad F, Verma A, Sharma H, et al. Carbon nanotubes: a targeted drug delivery against cancer cell. Current Nanoscience, (2024); 20(6): 769-800.

Eldridge BN, Bernish BW, Fahrenholtz CD, Singh R. Photothermal therapy of glioblastoma multiforme using multiwalled carbon nanotubes optimized for diffusion in extracellular space. ACS Biomaterials Science and Engineering, (2016); 2(6): 963-976.

Jayaprakash N, Elumalai K, Manickam S, Bakthavatchalam G, Tamilselvan P. Carbon nanomaterials: Revolutionizing biomedical applications with promising potential. Nano Materials Science, (2024); 6: 100688.

Nazeri Z, Zarezade V, Jamalan M, Cheraghzadeh M, Azizidoost S, et al. Carbon nanotubes induce cytotoxicity and apoptosis through increasing protein levels of Bax and ROS in mouse skin fibroblasts. Research in Pharmaceutical Sciences, (2024); 19(2): 148-156.

Rodolpho JMdA, Godoy KFd, Brassolatti P, Fragelli BDdL, Castro CAd, et al. Apoptosis and oxidative stress triggered by carbon black nanoparticle in the LA-9 fibroblast. Cellular Physiology and Biochemistry, (2021); 55(3): 364-377.

Myrzagali S, Omarova Z, Zeitkaziyeva D, Madet A, Xie Y. Carbon nanoparticle-induced cell death. Carbon Trends, (2024); 15: 100352.

Xuan L, Ju Z, Skonieczna M, Zhou PK, Huang R. Nanoparticles?induced potential toxicity on human health: applications, toxicity mechanisms, and evaluation models. MedComm, (2023); 4(4): e327.

Jia Y-Y, Zhang J-J, Zhang Y-X, Wang W, Li C, et al. Construction of redox-responsive tumor targeted cisplatin nano-delivery system for effective cancer chemotherapy. International Journal of Pharmaceutics, (2020); 580: 119190.

Pourmadadi M, Eshaghi MM, Rahmani E, Ajalli N, Bakhshi S, et al. Cisplatin-loaded nanoformulations for cancer therapy: A comprehensive review. Journal of Drug Delivery Science and Technology, (2022); 77: 103928.

Matalqah SM, Aiedeh K, Mhaidat NM, Alzoubi KH, Al-Husein BA. Preparation of modified chitosan-based nanoparticles for efficient delivery of doxorubicin and/or cisplatin to breast cancer cells. Current Cancer Drug Targets, (2022); 22(2): 133-141.

Guven A, Villares GJ, Hilsenbeck SG, Lewis A, Landua JD, et al. Carbon nanotube capsules enhance the in vivo efficacy of cisplatin. Acta Biomaterialia, (2017); 58: 466-478.

Qi Y, Yang W, Liu S, Han F, Wang H, et al. Cisplatin loaded multiwalled carbon nanotubes reverse drug resistance in NSCLC by inhibiting EMT. Cancer Cell International, (2021); 21: 233.

Maghimaa M, Sagadevan S, Boojhana E, Fatimah I, Lett JA, et al. Enhancing biocompatibility and functionality: Carbon nanotube-polymer nanocomposites for improved biomedical applications. Journal of Drug Delivery Science and Technology, (2024); 86: 105958.

Kumar S, Rani R, Dilbaghi N, Tankeshwar K, Kim K-H. Carbon nanotubes: a novel material for multifaceted applications in human healthcare. Chemical Society Reviews, (2017); 46(1): 158-196.

Pathak R, Punetha VD, Bhatt S, Punetha M. Carbon nanotube-based biocompatible polymer nanocomposites as an emerging tool for biomedical applications. European Polymer Journal, (2023); 189: 112257.

Chadar R, Afzal O, Alqahtani SM, Kesharwani P. Carbon nanotubes as an emerging nanocarrier for the delivery of doxorubicin for improved chemotherapy. Colloids and Surfaces B: Biointerfaces, (2021); 208: 112044.

Gayathri K, Vidya R. Carbon nanomaterials as carriers for the anti-cancer drug doxorubicin: a review on theoretical and experimental studies. Nanoscale Advances, (2024); 6(16): 3992-4014.

Alshaer W, Lafi Z, Nsairat H, AlQuaissi B, Alqudah DA, et al. Remote Co-Loading of Doxorubicin and Hydralazine into PEGylated Liposomes: In Vitro Anti-Proliferative Effect Against Breast Cancer. Molecules, (2025); 30(7): 1549.

Bahmani E, Dizaji BF, Talaei S, Koushkbaghi S, Yazdani H, et al. Fabrication of poly (??caprolactone)/paclitaxel (core)/chitosan/zein/multi?walled carbon nanotubes/doxorubicin (shell) nanofibers against MCF?7 breast cancer. Polymers for Advanced Technologies, (2023); 34(2): 789-799.

Qi X, Rui Y, Fan Y, Chen H, Ma N, et al. Galactosylated chitosan-grafted multiwall carbon nanotubes for pH-dependent sustained release and hepatic tumor-targeted delivery of doxorubicin in vivo. Colloids and Surfaces B: Biointerfaces, (2015); 133: 314-322.

Liu X, Shuai H-L, Liu Y-J, Huang K-J. An electrochemical biosensor for DNA detection based on tungsten disulfide/multi-walled carbon nanotube composites and hybridization chain reaction amplification. Sensors and Actuators B: Chemical, (2016); 235: 603-613.

Kumar S, Sidhu H, Paul AK, Bhardwaj N, Thakur NS, et al. Bioengineered multi-walled carbon nanotube (MWCNT) based biosensors and applications thereof. Sensors and Diagnostics, (2023); 2(6): 1390-1413.

Jin W, Zhang R, Dong C, Jiang T, Tian Y, et al. A simple MWCNTs@ paper biosensor for CA19-9 detection and its long-term preservation by vacuum freeze drying. International Journal of Biological Macromolecules, (2020); 144: 995-1003.

Arkan E, Saber R, Karimi Z, Shamsipur M. A novel antibody–antigen based impedimetric immunosensor for low level detection of HER2 in serum samples of breast cancer patients via modification of a gold nanoparticles decorated multiwall carbon nanotube-ionic liquid electrode. Analytica Chimica Acta, (2015); 874: 66-74.

Mazloum?Ardakani M, Hosseinzadeh L, Khoshroo A. Ultrasensitive electrochemical immunosensor for detection of tumor necrosis factor?? based on functionalized MWCNT?Gold Nanoparticle/Ionic Liquid Nanocomposite. Electroanalysis, (2015); 27(11): 2518-2526.

Kavosi B, Salimi A, Hallaj R, Amani K. A highly sensitive prostate-specific antigen immunosensor based on gold nanoparticles/PAMAM dendrimer loaded on MWCNTS/chitosan/ionic liquid nanocomposite. Biosensors and Bioelectronics, (2014); 52: 20-28.

Rahamathulla M, Bhosale RR, Osmani RA, Mahima KC, Johnson AP, et al. Carbon nanotubes: Current perspectives on diverse applications in targeted drug delivery and therapies. Materials, (2021); 14(21): 6707.

Prakash S, Malhotra M, Shao W, Tomaro-Duchesneau C, Abbasi S. Polymeric nanohybrids and functionalized carbon nanotubes as drug delivery carriers for cancer therapy. Advanced Drug Delivery Reviews, (2011); 63(14-15): 1340-1351.

Lu Y-J, Wei K-C, Ma C-CM, Yang S-Y, Chen J-P. Dual targeted delivery of doxorubicin to cancer cells using folate-conjugated magnetic multi-walled carbon nanotubes. Colloids and Surfaces B: Biointerfaces, (2012); 89: 1-9.

Nabawi HM, Abdelazem AZ, El Rouby WM, El?Shahawy AA. A potent formula against triple?negative breast cancer—sorafenib?carbon nanotubes?folic acid: Targeting, apoptosis triggering, and bioavailability enhancing. Biotechnology and Applied Biochemistry, (2023); 70(6): 2362-2375.

Jawahar N, De A, Jubee S, Reddy ES. Folic acid?conjugated raloxifene hydrochloride carbon nanotube for targeting breast cancer cells. Drug Development Research, (2020); 81(3): 305-314.

Halwai K, Khanna S, Gupta G, Wahab S, Khalid M, et al. Folate-conjugated carbon nanotubes as a promising therapeutic approach for targeted cancer therapy. Journal of Drug Targeting, (2024); 32(6): 1-16.

Zanganeh S, Khodadadei F, Tafti SR, Abdolahad M. Folic acid functionalized vertically aligned carbon nanotube (FA-VACNT) electrodes for cancer sensing applications. Journal of Materials Science and Technology, (2016); 32(7): 617-625.

González-Domínguez JM, Grasa L, Frontiñán-Rubio J, Abás E, Domínguez-Alfaro A, et al. Intrinsic and selective activity of functionalized carbon nanotube/nanocellulose platforms against colon cancer cells. Colloids and Surfaces B: Biointerfaces, (2022); 212: 112363.

Zhang J, Song L, Zhou S, Hu M, Jiao Y, et al. Enhanced ultrasound imaging and anti-tumor in vivo properties of Span–polyethylene glycol with folic acid–carbon nanotube–paclitaxel multifunctional microbubbles. RSC Advances, (2019); 9(61): 35345-35355.

Moghimi SM, Hamad I. Factors controlling pharmacokinetics of intravenously injected nanoparticulate systems: Nanotechnology in Drug Delivery. 2009; 267-282. Springer.

Singh R, Deshmukh R. Carbon nanotube as an emerging theranostic tool for oncology. Journal of Drug Delivery Science and Technology, (2022); 74: 103586.

Tang L, Xiao Q, Mei Y, He S, Zhang Z, et al. Insights on functionalized carbon nanotubes for cancer theranostics. Journal of Nanobiotechnology, (2021); 19: 147.

Kearns O, Camisasca A, Giordani S. Hyaluronic acid-conjugated carbon nanomaterials for enhanced tumour targeting ability. Molecules, (2021); 27(1): 48.

Mehra NK, Palakurthi S. Interactions between carbon nanotubes and bioactives: a drug delivery perspective. Drug Discovery Today, (2016); 21(4): 585-597.

Elsayed MM, Mostafa ME, Alaaeldin E, Sarhan HA, Shaykoon MS, et al. Design and characterisation of novel Sorafenib-loaded carbon nanotubes with distinct tumour-suppressive activity in hepatocellular carcinoma. International Journal of Nanomedicine, (2019); 14: 8445-8467.

Seyfoori A, Sarfarazijami S, Seyyed Ebrahimi S. pH-responsive carbon nanotube-based hybrid nanogels as the smart anticancer drug carrier. Artificial Cells, Nanomedicine, and Biotechnology, (2019); 47(1): 1437-1443.

Sonowal L, Gautam S. Advancements and challenges in carbon nanotube-based drug delivery systems. Nano-Structures and Nano-Objects, (2024); 38: 101117.

Morais RP, Novais GB, Sangenito LS, Santos AL, Priefer R, et al. Naringenin-functionalized multi-walled carbon nanotubes: a potential approach for site-specific remote-controlled anticancer delivery for the treatment of lung cancer cells. International Journal of Molecular Sciences, (2020); 21(12): 4557.

Dakilah I, Harb A, Abu-Gharbieh E, El-Huneidi W, Taneera J, et al. Potential of CDC25 phosphatases in cancer research and treatment: key to precision medicine. Frontiers in Pharmacology, (2024); 15: 1345672.

El Dakkak B, Taneera J, El-Huneidi W, Abu-Gharbieh E, Hamoudi R, et al. Unlocking the therapeutic potential of BCL-2 associated protein family: Exploring BCL-2 inhibitors in cancer therapy. Biomolecules and Therapeutics, (2024); 32(3): 267-280.

Sheikhpour M, Naghinejad M, Kasaeian A, Lohrasbi A, Shahraeini SS, et al. The applications of carbon nanotubes in the diagnosis and treatment of lung cancer: A critical review. International Journal of Nanomedicine, (2020); 15: 7063-7078.




DOI: https://doi.org/10.62940/als.v13i2.4048

Refbacks

  • There are currently no refbacks.