Pharmacological and antioxidant activities of a lyophilized extract of Salvia deserta Schangin

Guldana Shoinbayeva, Bayan Sagindykova, Saltanat Imanalieva, Gnk Ganesh, Dithu Thekkekkara, Saravana Babu Chidambaram

Abstract


Background: Salvia deserta Schangin (the Tartarian sage) is one of the little-studied species of the genus Salvia, despite the broad spectrum of biological activity of other representatives of this genus. The plant is common in Central Asia and is traditionally used in folk medicine, but its pharmacological properties have not yet been systematically investigated. The aim of the work was to experimentally study the pharmacological properties of the lyophilized extract of Salvia deserta Schangin, including the assessment of acute oral toxicity and analgesic, anti-inflammatory, and antioxidant activity.

Methods: The extract was obtained by ultrasonic extraction followed by lyophilization. Acute toxicity was determined according to OECD Guidelines No. 423. Analgesic activity was determined through the acetic acid writhing test in mice, and anti-inflammatory activity was tested in a model of carrageenan-induced paw edema in rats. Antioxidant properties were assessed using the DPPH and FRAP methods.

Results: The lyophilic extract of Salvia deserta Schangin showed low acute toxicity (LD??> 2,000 mg/kg), a pronounced analgesic effect comparable to that of diclofenac sodium, and a significant anti-inflammatory effect at a dose of 400 mg/kg. In DPPH and FRAP tests, the extract showed high antioxidant activity (EC?? = 11.85 ?g/ml; IC?? = 10.4399 ?g/ml).

Conclusion: The obtained results demonstrate the strong pharmacological effects of the Tartarian sage and prove it to be a promising source of biologically active compounds with analgesic, anti-inflammatory, and antioxidant properties. The study presents the first comprehensive assessment of the pharmacological activity of the lyophilized extract of Salvia deserta Schangin, which gives grounds to consider this species as a new promising object for the development of phytopreparations.

Keywords: Tartarian sage, Antinociceptive activity, Anti-inflammatory activity, Medicinal plant raw materials


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DOI: https://doi.org/10.62940/als.v13i2.4101

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