Study on significant changes in calcium, phosphorus and thyroid hormones level in hypothyroidism patients

Nida Zahra, Ahmad Ali, Saima Kousar, Arif Malik, Ahmad Zaheer, Imran Riaz Malik

Abstract


Background: Thyroid hormones have a vital role in metabolism of lipids, cholesterol etc. They also have an important role in phosphorous and calcium homeostasis by their direct effect on bone turnover. The objective of present study was to find the significant differences of T3, T4, TSH, lipid profile (HDL, LDL, vLDL, TG, Cholesterol), electrolytes and minerals (sodium, potassium, chloride, phosphorus, calcium) between control group and hypothyroidism patients.

Methods: Blood samples were collected from 72 patients and 12 control after their consent. Serum was used to determine biochemical parameters using standard protocol. Data obtained were statistically analyzed using “t” student test.

Results: The level of TSH was significantly higher in female and male hypothyroidism patients (p < 0.01) as compared to control and it was inversely related to the level of T3 and T4. Patients with hypothyroidism have increased level of LFTs profile especially cholesterol and Triglycerides levels both in males and females. In hypothyroidism, the level of glomerulus filtrate rate decrease especially sodium level but thyroid hormonal disturbance does not affect serum electrolyte level. The serum phosphorus and calcium levels change significantly in thyroid disorder.

Conclusion: Hypothyroidism is associated with increased TSH level and decreased T3 and T4 levels but does not appear to be associated with abnormalities in lipid profile. The serum phosphorus and calcium levels change significantly in thyroid disorder, Treatments of its primary causes should be given and if it is possible minerals can be added to avoid further bone complications.

Keywords: Hypothyroid; T3; T4, TSH; Lipid profile; Mineral


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References


Malik IR, Raza UA, Yasin M, Zaheer A, Malik A, Alam R. Study of oxidative stress parameters in patientns with hyperthyroidis. Electronic Journal of Biology, (2018); 14(4): 102-105.

Becker DV, Bigos ST, Gaitan E. Optimal use of blood tests for assessment of thyroid function. Thyroid, (1993); 3: 353-354.

Bensenor IM, Olmos RD, Lotufo PA. Hypothyroidism in the elderly: diagnosis and management. Clinical Interventions in Aging, (2012); 7: 97-111.

Cappola R, Ladenson PW. Hypothyroidism and atherosclerosis. The Journal of Clinical Endocrinology and Metabolism, (2003); 6(88); 2438-2444.

Chuang CC, Wang ST, Wang PW, Yu ML. Prevalence study of thyroid dysfunction in the elderly of Taiwan. Gerontology, 1998; 44(3);162-167.

Cooper DS. Clinical Practice: Subclinical Hypothyroidism. The New England Journal of Medicine, (2001); 345(4); 260-265.

Ashmaik AS, Gabra HM, Elzein AO, Shrif NEMA, Hassan EE. Asian Journal of Biomedical and Pharaceutical Sciences, (2013); 3(25): 21-26.

Suneel B, Nagendra DR, Apama RR, Balalkrishna D, Naidu JN. Mineral Status I n Thyroid ( Hypo & Hyper). International Journal of Appliedd Biology and Pharmaceutical Technology, (2011); 2(4): 424-429.

Schwarza C, Leichtle AB, Spiros A, George MF, Heins F, Aritmenis K, Gregor L. Thyroid function and serum electrolytes. Swiss Medical Weekly, (2012); 13669-142.

Gutch M, Rungta S, Kumar S, Agarwal A, Bhattacharya A, Razi SM. Thyroid functions and serum lipid profile in metabolic syndrome. Biomedical journal, (2017); 40(3), 147-153.

Hassan SH, Ali A, Ali JK. Assessment Levels of Some Electrolytes in Hypothyroidism Patients. International Journal of Pure and Applied Bioscience, (2019); 7(2); 10-14.

Krishna MCS, Kumara HDS, Vishwanath HL. Study on the Electrolytes and Hypothyroidism – A Case Control Study. Biochemistry: an Indian journal, (2018); 12(2):131-134.

Mohamed RJ. Relationship Between Disorder of Thyroid Gland and the levels of T3, T4 and TSH Hormones. Journal of Kerbala University, (2016); 14(2), 16-23.

Shivaleela MB, Poornima RT, Jayaprakash Murthy DS. Serum calcium and phosphorous levels in thyroid dysfunction. Indian Journal of Fundamental and Applied Life Science, (2012); 2(2); 179-83.

Staii A, Mirocha S, Todorova-Koteva K, Glinberg S, Jaume JC. Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state. Thyroid research, (2010); 3(1): 11

Surks MI, Ortiz E, Daniels GH, Sawin CT, Cobin RH. Al Subclinical thyroid disease, scientific review and guidelines for diagnosis and management. The Journal of the American Medical Association, (2004); 291: 228-238.

Vanderpump MP, Turnbridge WM. Epidemiology and prevention of clinical and subclinical hypothyroidism. Thyroid, (2002); 12: 839-47.




DOI: http://dx.doi.org/10.62940/als.v8i1.972

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